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Bio-compatible, bio-degradable, and bio-available excipients are of critical interest
for drug delivery systems. Cellulose and its derivative-based excipients have been
well studied due to their green/natural and unique encapsulation/binding properties. They
are often used in controlled/sustained drug delivery systems. In these applications, cellulose
and its derivatives function generally can modify the solubility/gelling behavior of
drugs, resulting in different mechanisms for controlling the release profiles of drugs. In
this paper, the current knowledge in the structure and chemistry of conventional cellulose
derivatives, and their applications in drug delivery systems are briefly reviewed. The development
of innovative cellulose-based materials, including micro-cellulose (MC) and
nano-cellulose (NC) in the applications of sustained drug delivery, is also discussed.