Recent Advances In The Use Of Algal Polysaccharides For Skin Wound Healing.
Suneel Kumar, Ileana Marrero-Berríos, Maciej Kabat, François Berthiaume
Published 2019 · Medicine, Biology
Download PDFAnalyze on Scholarcy
BACKGROUND Chronic skin wounds and pressure ulcers represent major health care problems in diabetic individuals, as well as patients who suffered a spinal cord injury. Current treatment methods are only partially effective and such wounds exhibit a high recurrence rate. Open wounds are at high risk of invasive wound infections, which can lead to amputation and further disability. An interdisciplinary approach is needed to develop new and more effective therapies. METHODS The purpose of this work is to review recent studies focusing on the use of algal polysaccharides in commercially available as well as experimental wound dressings. Studies that discuss wound dressings based on algal polysaccharides, some of which also contain growth factors and even living cells, were identified and included in this review. RESULTS AND CONCLUSION Algal polysaccharides possess mechanical and physical properties, along with excellent biocompatibility and biodegradability that make them suitable for a variety of applications as wound dressings. Furthermore, algal polysaccharides have been used for a dual purpose, namely as wound covering, but also as a vehicle for drug delivery to the wound site.
This paper references
Development of novel alginate based hydrogel films for wound healing applications.
Rúben F. Pereira (2013)
Design of a novel wound dressing consisting of alginate hydrogel and simvastatin-incorporated mesoporous hydroxyapatite microspheres for cutaneous wound healing
Weilin Yu (2016)
Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications.
Elena Geta Popa (2015)
Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings.
Kaoru Murakami (2010)
Multifunctional medicated lyophilised wafer dressing for effective chronic wound healing.
Harshavardhan V Pawar (2014)
Electrospun biocomposite nanofibers of ulvan/PCL and ulvan/PEO
Stefanos Kikionis (2015)
Design and evaluation of effervescent floating tablets based on hydroxyethyl cellulose and sodium alginate using pentoxifylline as a model drug
Safwan Abdel Rahim (2015)
Processing of degradable ulvan 3D porous structures for biomedical applications.
Anabela Alves (2013)
Thermoresponsive chitosan-agarose hydrogel for skin regeneration.
Sónia P. Miguel (2014)
Alginate in Wound Dressings
B. A. Aderibigbe (2018)
Diabetic Foot Ulcers and Their Recurrence.
David G. Armstrong (2017)
The synthesis and characterization of hydrogel chitosan-alginate with the addition of plasticizer lauric acid for wound dressing application
Djony Izak Rudyardjo (2017)
Development of polyvinyl alcohol-sodium alginate gel-matrix-based wound dressing system containing nitrofurazone.
Jong Oh Kim (2008)
Impact of Complete Spinal Cord Injury on Healing of Skin Ulcers in Mouse Models.
Suneel Kumar (2018)
Antihyperlipidemic activity of high sulfate content derivative of polysaccharide extracted from Ulva pertusa (Chlorophyta)
Huimin Qi (2012)
Human Wounds and Its Burden: An Updated Compendium of Estimates.
Chandan K. Sen (2019)
Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII.
Anne Bee Hegge (2011)
Evaluation of porphyrin loaded dry alginate foams containing poloxamer 407 and β-cyclodextrin-derivatives intended for wound treatment
Victoria J. Valerón Bergh (2018)
Practices and exploration on competition of molecular biological detection technology among students in food quality and safety major.
Yaning Chang (2017)
All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties.
Ioannis L. Liakos (2014)
Impact of magnetic nanofillers in the swelling and release properties of κ-carrageenan hydrogel nanocomposites
Ana L. Daniel-da-Silva (2012)
Processing ulvan into 2D structures: cross-linked ulvan membranes as new biomaterials for drug delivery applications.
Anabela Alves (2012)
Formation and enzymatic degradation of poly-l-arginine/fucoidan multilayer films.
Jessie L Webber (2017)
Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits.
Ali Demir Sezer (2008)
Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair.
Ronan O’Leary (2004)
Preparation of sodium alginate/poly(ethylene oxide) blend nanofibers with lecithin
Su A Park (2010)
Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh.
José Manuel Leiro (2007)
Alginate-lavender nanofibers with antibacterial and anti-inflammatory activity to effectively promote burn healing.
Hadi Hajiali (2016)
Radiation synthesis of poly(N-vinyl-2-pyrrolidone)-kappa-carrageenan hydrogels and their use in wound dressing applications. I. Preliminary laboratory tests.
Murat Şen (2005)
A comparative study of crosslinked sodium alginate/gelatin hydrogels for wound dressing
Aamarjargal Saarai (2011)
Alginate Hydrogels Coated with Chitosan for Wound Dressing
Maria Cristina Straccia (2015)
ELEKTRO ÇEKİM YÖNTEMİ İLE ÜRETİLMİŞ POLİ(VİNİL ALKOL)/SODYUM ALGİNAT NANOLİFLİ YÜZEYİN YARA ÖRTÜSÜ OLARAK IN VIVO DEĞERLENDİRMESİ
Gökçe Coşkun Üstündağ (2010)
Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity.
Jong-Il Choi (2013)
Wound Dressings from Algal Polymers
Monica Bhatnagar (2015)
Enzymatically Crosslinked Ulvan Hydrogels as Injectable Systems for Cell Delivery
Andrea Morelli (2016)
Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration.
Garazi Gainza (2015)
Ulvan as a New Type of Biomaterial from Renewable Resources: Functionalization and Hydrogel Preparation
Andrea Morelli (2010)
Alginate composites for bone tissue engineering: a review.
Jayachandran Venkatesan (2015)
On the characterization of sodium alginate/gelatine‐based hydrogels for wound dressing
Amarjargal Saarai (2012)
Development of a PVP/kappa-carrageenan/PEG hydrogel dressing for wound healing applications in Sri Lanka
D. Awanthi De Silva (2011)
Marine Polysaccharides from Algae with Potential Biomedical Applications
M. F. J. Raposo (2015)
Carrageenan as a functional additive in the production of cheese and cheese-like products.
Błażej B Błaszak (2018)
Composite alginate and gelatin based bio-polymeric wafers containing silver sulfadiazine for wound healing.
Joshua S Boateng (2015)
Sizes and Sufficient Quantities of MSC Microspheres for Intrathecal Injection to Modulate Inflammation in Spinal Cord Injury.
Suneel Kumar (2015)
Calcium alginate enhances wound healing by up-regulating the ratio of collagen types I/III in diabetic rats.
Tao Wang (2015)
The characterization of alginate wound dressings with different fiber and textile structures
Yimin Qin (2006)
Corrigendum to “Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings” (Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings (2011) 49(3) (247–254), (S01418
K. T. Shalumon (2019)
Biosensors coated with sulfated polysaccharides for the detection of hepatocyte growth factor/scatter factor in cell culture medium.
Manuel Berger (2010)
Electrospun Sodium Alginate/Polyethylene Oxide Fibers and Nanocoated Yarns
Cejun Hu (2015)
Basic fibroblast growth factor released from fucoidan-modified chitosan/alginate scaffolds for promoting fibroblasts migration
Huang-Yu Zeng (2018)
The biological effects of topical alginate treatment in an animal model of skin wound healing.
Woo-Ram Lee (2009)
Physiological changes in tissues denervated by spinal cord injury tissues and possible effects on wound healing.
Laurie M. Rappl (2008)
Design and development of antimicrobial wafers for chronic wound healing
Devegowda Vishakante Gowda (2016)
Chitosan film containing fucoidan as a wound dressing for dermal burn healing: Preparation and in vitro/in vivo evaluation
Ali Demir Sezer (2007)
Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo.
Gökçe Coşkun (2014)
Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings.
K. T. Shalumon (2011)
In vitro antioxidant activity of acetylated and benzoylated derivatives of polysaccharide extracted from Ulva pertusa (Chlorophyta).
Huimin Qi (2006)
Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation
Elbadawy A. Kamoun (2015)
Alginate: properties and biomedical applications.
Kuen Yong Lee (2012)
Development of highly biocompatible Gelatin & i-Carrageenan based composite hydrogels: In depth physiochemical analysis for biomedical applications.
Jyostna Rani Padhi (2016)
Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing
Rozaini Mohd Zohdi (2012)
Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
Annapoorna Mohandas (2015)
Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.
Kerr H Matthews (2005)
II. Characterizations of Alginate-Chitosan Hydrogel for Wound Dressing Application
Nan Xing (2012)
Films based on soy protein-agar blends for wound dressing: Effect of different biopolymer proportions on the drug release rate and the physical and antibacterial properties of the films
Josefina Rivadeneira (2018)
The local treatment and available dressings designed for chronic wounds.
Katarzyna Skórkowska-Telichowska (2013)
A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application
Ruoqiu Fu (2016)
Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice
Young-in Kim (2018)
Effectiveness of Disinfectants on Antimicrobial and Physical Properties of Dental Impression Materials.
Jean Karl Demajo (2016)
Cyclic β-(1→3) (1→6) glucan/carrageenan hydrogels for wound healing applications
Anju V. Nair (2016)
Producing novel edible films from semi refined carrageenan (SRC) and ulvan polysaccharides for potential food applications.
Abirami Ramu Ganesan (2018)
Radiation synthesis of PVP/alginate hydrogel containing nanosilver as wound dressing
Rita Singh (2012)
A novel wound dressing material — fibrin–chitosan–sodium alginate composite sheet
M. Pandima Devi (2012)
Advanced Therapeutic Dressings for Effective Wound Healing--A Review.
Joshua S Boateng (2015)
Photocrosslinkable kappa-carrageenan hydrogels for tissue engineering applications.
Silvia M. Mihaila (2013)
Nanofibers based on polysaccharides from the green seaweed Ulva Rigida
Georgios Toskas (2011)
Fabrication and Physical Properties of Gelatin/Sodium Alginate/Hyaluronic Acid Composite Wound Dressing Hydrogel
Zhihua Zhou (2014)
The effect of dietary Laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs.
Mary B Lynch (2010)
Agar/collagen membrane as skin dressing for wounds.
Lei Bao (2008)
Anti-inflammatory compounds of macro algae origin: A review
Irwandi Jaswir (2011)
Evaluation of Effectiveness of Honey-Based Alginate Hyrogel on Wound Healing in a Mouse Model of Rat
Saeed Nazeri (2015)
Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification.
Marco Garcia-Vaquero (2017)
Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing.
Joshua S Boateng (2013)
Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing.
Hnin-Ei Thu (2012)
A systematic review of risk factors for the development and recurrence of pressure ulcers in people with spinal cord injuries
Josefina Calzontzi Marín (2013)
This paper is referenced by
Therapeutic Potential and Drug Delivery Applications of Algal Polysaccharides.
Indu Pal Kaur (2019)
Rational design and latest advances of polysaccharide-based hydrogels for wound healing.
Hao Hu (2020)
Sarcodia suieae acetyl-xylogalactan regulate RAW 264.7 macrophage NF-kappa B activation and IL-1 beta cytokine production in macrophage polarization
Tsung-meng Wu (2019)