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Optimizing Hemithoracic Pleural Intensity-modulated Radiation Therapy For Malignant Pleural Mesothelioma

F. Shaikh, A. Rimner
Published 2015 · Medicine

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The treatment of malignant pleural mesothelioma (MPM) remains challenging. Optimal management for resectable patients involves an aggressive approach, frequently using trimodality therapy. Historically, poor tumor control and profound pulmonary toxicity prevented conventional radiation therapy from being widely used. The advent of intensity-modulated radiation therapy was a major development in the delivery of radiation for MPM in the adjuvant setting, improving target coverage and dose homogeneity while maintaining acceptable toxicity profiles. Nevertheless, there remains a significant risk of severe pulmonary toxicity, ameliorated by careful target delineation, treatment planning and proactive toxicity management. Innovative technology, including arc therapy, simultaneous integrated boosts and proton therapy as well as neodjuvant delivery of radiation followed by pneumonectomy are being actively investigated to improve outcomes in the treatment of MPM.
This paper references
Patterns of Local and Nodal Failure in Malignant Pleural Mesothelioma After Extrapleural Pneumonectomy and Photon-Electron Radiotherapy
V. Gupta (2009)
Adjuvant intensity-modulated proton therapy in malignant pleural mesothelioma
S. Lorentini (2011)
Failure patterns after hemithoracic pleural intensity modulated radiation therapy for malignant pleural mesothelioma.
A. Rimner (2014)
Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: helical tomotherapy compared with step-and-shoot IMRT.
F. Sterzing (2008)
Dose-dependent pulmonary toxicity after postoperative intensity-modulated radiotherapy for malignant pleural mesothelioma.
D. Rice (2007)
PET-guided dose escalation tomotherapy in malignant pleural mesothelioma
Andrei Fodor (2011)
Comparison of CT and integrated PET-CT based radiation therapy planning in patients with malignant pleural mesothelioma
B. Pehlivan (2009)
Mesothelioma at era of helical tomotherapy: results of two institutions in combining chemotherapy, surgery and radiotherapy.
A. Sylvestre (2011)
External beam radiation therapy for the treatment of pleural mesothelioma.
E. Baldini (2004)
Hemithoracic radiation after extrapleural pneumonectomy for malignant pleural mesothelioma.
S. Yajnik (2003)
Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma.
V. Gupta (2005)
Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients.
R. Flores (2008)
Recommendations for Uniform Definitions of Surgical Techniques for Malignant Pleural Mesothelioma: A Consensus Report of the International Association for the Study of Lung Cancer International Staging Committee and the International Mesothelioma Interest Group
D. Rice (2011)
Tomotherapy after pleurectomy or decortication or biopsy for malignant pleural mesothelioma.
M. Trovò (2013)
Phase I/II study of monoclonal antibody against Lewis Y hapten in relapsed small-cell lung cancer.
R. Stahel (1992)
Pleurectomy/decortication, chemotherapy, and intensity modulated radiation therapy for malignant pleural mesothelioma: rationale for multimodality therapy incorporating lung-sparing surgery.
M. Zauderer (2012)
A Feasibility Study Evaluating Surgery for Mesothelioma After Radiation Therapy: The “SMART” Approach for Resectable Malignant Pleural Mesothelioma
B. Cho (2014)
Pulmonary toxicity following IMRT after extrapleural pneumonectomy for malignant pleural mesothelioma.
C. Kristensen (2009)
Proton therapy for malignant pleural mesothelioma after extrapleural pleuropneumonectomy.
J. Krayenbuehl (2010)
Tomotherapy after Pleurectomy/Decortication or Biopsy for Malignant Pleural Mesothelioma Allows the Delivery of High Dose of Radiation in Patients with Intact Lung
E. Minatel (2012)
Establishing locoregional control of malignant pleural mesothelioma using high‐dose radiotherapy and 18F‐FDG PET/CT scan correlation
M. Feigen (2011)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
T. Treasure (2011)
Novel radiation therapy approaches in malignant pleural mesothelioma.
A. Rimner (2012)
Interim Analysis of a Phase 2 Toxicity Study on Hemithoracic Pleural Intensity Modulated Radiation Therapy (IMRT) for Malignant Pleural Mesothelioma (MPM)
A. Rimner (2013)
Patterns of Failure, Toxicity, and Survival after Extrapleural Pneumonectomy and Hemithoracic Intensity-Modulated Radiation Therapy for Malignant Pleural Mesothelioma
D. Gomez (2013)
Early experience with intensity modulated proton therapy for lung-intact mesothelioma: A case series.
H. Pan (2015)
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma.
N. Vogelzang (2003)
Meta-analysis of survival after pleurectomy decortication versus extrapleural pneumonectomy in mesothelioma.
E. Taioli (2015)
Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience.
E. Miles (2008)
Pleural intensity-modulated radiotherapy for malignant pleural mesothelioma.
K. Rosenzweig (2012)
Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma.
A. Allen (2006)
A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma.
V. Rusch (2001)

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