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Antimicrobial Activity Screening Of Isolated Flavonoids From Azadirachta Indica Leaves

Qudsia Kanwal, Ishtiaq Hussain, Latif Siddiqui, Arshad Javaid

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The antimicrobial activities of two flavonoids, namely Genisteina A 7-O-glucoside (1) and (-)-Epi-catechin (2), isolated from Azadirachta indica A. Juss (neem) leaves, were evaluated against five fungal species, viz: Alternaria alternata (Fr.) Keissler, Aspergillus fumigatus Fresenius, Aspergillus niger van Tieghem, Macrophomina phaseolina (Tassi) Goid. and Penicillium citrii, and four bacterial species, viz: Lactobacillus sp., Escherichia coli, Azospirillium lipoferum and Bacillus sp. Six concentrations, viz. 100, 300, 500, 700, 900 and 1000 ppm of each of the two flavonoids were employed using malt extract agar medium. All the concentrations of both the test compounds significantly suppressed fungal as well as bacterial growth. The highest concentration (1000 ppm) of both fractions 1 and 2 reduced the growth of the different test fungal species by 83-99 % and 82-95 %, respectively. Compound 1 was highly effective against Lactobacillus sp., against which its various concentrations reduced the bacterial growth by 52-99.8 %. Compound 2 was highly effective against A. lipoferm and Bacillus sp., resulting in 94- 100 % and 73-99% reduction in bacterial growth, respectively.