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Cancer Incidence In Atomic Bomb Survivors. Part II: Solid Tumors, 1958-1987.

D. Thompson, K. Mabuchi, E. Ron, M. Soda, M. Tokunaga, S. Ochikubo, S. Sugimoto, T. Ikeda, M. Terasaki, S. Izumi
Published 1994 · Medicine

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This report presents, for the first time, comprehensive data on the incidence of solid cancer and risk estimates for A-bomb survivors in the extended Life Span Study (LSS-E85) cohort. Among 79,972 individuals, 8613 first primary solid cancers were diagnosed between 1958 and 1987. As part of the standard registration process of the Hiroshima and Nagasaki tumor registries, cancer cases occurring among members of the LSS-E85 cohort were identified using a computer linkage system supplemented by manual searches. Special efforts were made to ensure complete case ascertainment, data quality and data consistency in the two cities. For all sites combined, 75% of the cancers were verified histologically, 6% were diagnosed by direct observation, 8% were based on a clinical diagnosis, and 12.6% were ascertained by death certificate only. A standard set of analyses was carried out for each of the organs and organ systems considered. Depending on the cancer site, Dosimetry System 1986 (DS86) organ or kerma doses were used for computing risk estimates. Analyses were based on a general excess relative risk model (the background rate times one plus the excess relative risk). Analyses carried out for each site involved fitting the background model with no dose effect, a linear dose-response model with no effect modifiers, a linear-quadratic dose-response model with no effect modifiers, and a series of linear dose-response models that included each of the covariates (sex, age at exposure, time since exposure, attained age and city) individually as effect modifiers. Because the tumor registries ascertain cancers in the registry catchment areas only, an adjustment was made for the effects of migration. In agreement with prior LSS findings, a statistically significant excess risk for all solid cancers was demonstrated [excess relative risk at 1 Sv (ERR1Sv) = 0.63; excess absolute risk (EAR) per 10(4) person-year sievert (PY Sv) = 29.7]. For cancers of the stomach (ERR1SV = 0.32), colon (ERR1SV = 0.72), lung (ERR1SV = 0.95), breast (ERR1SV = 1.59), ovary (ERR1SV = 0.99), urinary bladder (ERR1SV = 1.02) and thyroid (ERR1SV = 1.15), significant radiation associations were observed. There was some indication of an increase in tumors of the neural tissue (excluding the brain) among persons exposed to the bombs before age 20. For the first time, radiation has been associated with liver (ERR1SV = 0.49) and nonmelanoma skin (ERR1SV = 1.0) cancer incidence in the LSS cohort. The present analysis also strengthened earlier findings, based on a smaller number of cases, of an effect of A-bomb radiation on salivary gland cancer.(ABSTRACT TRUNCATED AT 400 WORDS)
This paper references
10.1093/JNCI/81.17.1307
Breast cancer in women with scoliosis exposed to multiple diagnostic x rays.
D. Hoffman (1989)
10.1001/JAMA.1987.03400050071030
Thyroid neoplasia in Marshall Islanders exposed to nuclear fallout.
T. E. Hamilton (1987)
10.2307/3577477
Radiation dose and second cancer risk in patients treated for cancer of the cervix.
J. Boice (1988)
10.1259/0007-1285-42-499-519
The late effects of artificial menopause by X-radiation.
D. Brinkley (1969)
10.1016/0002-9378(56)90371-4
Pelvic carcinoma following irradiation for benign gynecological diseases.
J. P. Palmer (1956)
10.2307/3577117
The effect of changes in dosimetry on cancer mortality risk estimates in the atomic bomb survivors.
D. Preston (1988)
10.1093/JNCI/77.3.689
Breast cancer among women given X-ray therapy for acute postpartum mastitis.
R. Shore (1986)
10.1259/0007-1285-54-639-187
Mortality from cancer and all causes among British radiologists.
P. Smith (1981)
10.1001/ARCHDERM.1989.01670190055005
Prior x-ray therapy for acne related to tumors of the parotid gland.
S. Preston-Martin (1989)
10.1016/0027-5107(87)90310-1
A collaborative exercise on cytogenetic dosimetry for simulated whole and partial body accidental irradiation.
D. Lloyd (1987)
Thorotrast exposure and cancer risk.
J. Olsen (1990)
10.1093/JNCI/80.17.1387
Cancer incidence after radiotherapy for skin hemangioma: a retrospective cohort study in Sweden.
C. Fürst (1988)
10.2307/3578894
Cancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality.
E. Ron (1994)
10.1093/OXFORDJOURNALS.AJE.A112087
The current mortality rates of radiologists and other physician specialists: specific causes of death.
G. Matanoski (1975)
10.2307/3576713
Risk of extrathyroid tumors following radiation treatment in infancy for thymic enlargement.
N. Hildreth (1985)
10.1093/JNCI/68.1.3
Neoplasms following childhood radium irradiation of the nasopharynx.
D. Sandler (1982)
10.2307/3578322
Issues and epidemiological evidence regarding radiation-induced thyroid cancer.
R. Shore (1992)
Second cancer following cancer of the female genital system in Connecticut, 1935-82.
R. Curtis (1985)
10.2307/3576533
Skin cancer incidence among children irradiated for ringworm of the scalp.
R. Shore (1984)
10.1097/00004032-197812000-00007
Alpha irradiation of the skin and the possibility of late effects.
M. Ševcová (1978)
10.1093/JNCI/86.11.842
Cancer following radiotherapy for peptic ulcer.
M. Griem (1994)
10.1056/NEJM198911093211902
Mortality from breast cancer after irradiation during fluoroscopic examinations in patients being treated for tuberculosis.
A. Miller (1989)
10.1093/jnci/66.6.1192
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.
R. Doll (1981)
10.1093/JNCI/28.5.1173
Prenatal x-ray exposure and childhood cancer.
B. Macmahon (1962)
10.1093/JNCI/80.12.943
Prior exposure to medical and dental x-rays related to tumors of the parotid gland.
S. Preston-Martin (1988)
10.1111/j.1749-6632.1990.tb32060.x
Accuracy of Cause‐of‐Death Certification in Hiroshima and Nagasaki, Japan
S. Jablon (1990)
10.2307/3577801
Thyroid neoplasia following low-dose radiation in childhood.
Eugenia Ron (1989)
Cancer mortality in a radiation-exposed cohort of Massachusetts tuberculosis patients.
F. Davis (1989)
10.1002/1097-0142(19830615)51:12<2159::AID-CNCR2820511202>3.0.CO;2-L
Neurilemomas and salivary gland tumors of the head and neck following childhood irradiation
E. Shore-Freedman (1983)
10.1093/JNCI/80.5.344
Cancer among medical diagnostic x-ray workers in China.
J. Wang (1988)
10.1002/1097-0142(19910201)67:3<746::AID-CNCR2820670336>3.0.CO;2-1
Comparative epidemiology of cancer between the united states and japan. A second look
E. Wynder (1991)
10.1056/NEJM198810203191601
Tumors of the brain and nervous system after radiotherapy in childhood.
Eugenia Ron (1988)
10.1056/NEJM198911093211901
The risk of breast cancer after irradiation of the thymus in infancy.
N. Hildreth (1989)
10.1038/bjc.1984.237
Endometrial cancer following treatment for breast cancer: a case-control study in Denmark.
M. Ewertz (1984)
10.2307/3577733
Allowing for random errors in radiation dose estimates for the atomic bomb survivor data.
D. Pierce (1990)
10.1259/0007-1285-41-485-362
Late effects of x irradiation in patients treated for metropathia haemorrhagica.
P. Smith (1976)
10.1002/1097-0142(197902)43:2<723::AID-CNCR2820430248>3.0.CO;2-1
Ovarian cancer. Incidence and case‐control study
J. F. Annegers (1979)
10.1136/bmj.291.6493.440
Mortality of employees of the United Kingdom Atomic Energy Authority, 1946-1979.
V. Beral (1985)
10.1093/OXFORDJOURNALS.RPD.A079681
Chromosome Aberrations Induced in Human Lymphocytes by In Vitro Acute X and Gamma Radiation
D. Lloyd (1986)
10.3327/JAESJ.29.690
US-Japan Joint Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki (Final Report)
Eizo Tajima (1987)
10.2307/3577741
Cancer mortality following radium treatment for uterine bleeding.
P. Inskip (1990)
10.1002/1097-0142(197502)35:2<555::AID-CNCR2820350240>3.0.CO;2-G
Salivary gland neoplasms following atomic radiation: Additional cases and reanalysis of combined data in a fixed population, 1957–1970
J. Belsky (1975)
10.1038/bjc.1987.35
Long term mortality after a single treatment course with X-rays in patients treated for ankylosing spondylitis.
S. Darby (1987)
10.1093/JNCI/75.1.1
A parallel analysis of cancer mortality among atomic bomb survivors and patients with ankylosing spondylitis given X-ray therapy.
S. Darby (1985)
10.2307/2347496
A Method for Computing Profile-Likelihood- Based Confidence Intervals
D. Venzon (1988)
10.2307/3577890
Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts.
J. Boice (1991)
10.1097/00004032-197807000-00013
Malignancies in Portuguese thorotrast patients.
J. da Silva Horta (1978)
10.1289/EHP.9087123
Using mortality data to estimate radiation effects on breast cancer incidence.
D. Hoel (1990)
10.1093/JNCI/74.6.1177
Thyroid tumors following thymus irradiation.
R. Shore (1985)
10.1093/JNCI/74.5.955
Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries.
J. Boice (1985)
10.2307/3578893
Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987.
D. Preston (1994)
10.1080/09553009014550951
Overview of radiation-induced skin cancer in humans.
R. Shore (1990)
10.2307/3578891
Cancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies.
K. Mabuchi (1994)



This paper is referenced by
10.1118/1.598209
The linear no-threshold response: why not linearity?
Warren K. Sinclair (1998)
10.1002/ijc.11258
Thyroid cancer risk after thyroid examination with 131I: A population‐based cohort study in Sweden
P. Dickman (2003)
10.1038/nrc722
Second cancers in survivors of childhood cancer
S. Bhatia (2002)
10.1016/S0531-5131(03)01143-9
Current situation and future planning of molecular epidemiology of radiation health effects around Chernobyl and Semipalatinsk
S. Yamashita (2003)
10.1667/RR3385.1
Uses of Dosimetry in Radiation Epidemiology
S. Simon (2006)
10.11343/AMN.55.61
Peripheral Organ Dose Evaluation using a Human Body Phantom in Intensity Modulated Radiation Therapy for Lung Cancer with Helical Type Accelerator
Shinichi Gotoh (2011)
10.1253/CIRCJ.CJ-08-0680
Men with Brugada-like electrocardiogram have higher risk of prostate cancer.
Daisuke Haruta (2009)
10.1667/RR2841.1
Effects of Radiation and Lifestyle Factors on Risks of Urothelial Carcinoma in the Life Span Study of Atomic Bomb Survivors
E. Grant (2012)
10.1371/journal.pone.0072143
Multiple Susceptibility Loci for Radiation-Induced Mammary Tumorigenesis in F2[Dahl S x R]-Intercross Rats
Victoria L. M. Herrera (2013)
10.2478/v10152-012-0021-0
Occupational exposure to ionizing radiation for medical workers
Andreja Vendramin (2012)
Temporal distribution of radiation induced leukaemia
(2008)
10.1667/RR1092.1
Improved Estimates of Cancer Site-Specific Risks for A-Bomb Survivors
D. Pawel (2008)
10.1210/JC.2006-0743
Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis.
S. Sadetzki (2006)
Risk o f S econd M alignancy A fter H odgkin's D isease i n a Collaborative B ritish C ohort: T he R elation t o A ge a t T reatment
G. Hudson (2000)
10.1200/JCO.2000.18.12.2435
Second cancers among long-term survivors of Hodgkin's disease diagnosed in childhood and adolescence.
C. Metayer (2000)
10.1002/cncr.23414
Significance of HER2 and C‐MYC oncogene amplifications in breast cancer in atomic bomb survivors
S. Miura (2008)
Australian participants in British nuclear tests in Australia, Vol 2: Mortality and cancer incidence
R. Gun (2006)
10.1186/s12886-017-0435-1
The risk of cataractogenesis after gamma knife radiosurgery: a nationwide population based case-control study
C. Liang (2017)
10.1006/PMED.1996.9979
Risk factors for primary breast cancer in Japan: 8-year follow-up of atomic bomb survivors.
M. Goodman (1997)
10.1080/095530097143923
The risk of non-melanoma skin cancer incidence in the Japanese atomic bomb survivors.
M. Little (1997)
10.1088/0952-4746/16/3/002
The projection of cancer and overall mortality rates in extreme old age and their impact on population cancer risks
M. Little (1996)
10.1089/105072504322880382
Changing trends of incidence and prognosis of thyroid carcinoma in lower Franconia, Germany, from 1981-1995.
J. Farahati (2004)
10.1007/S00268-004-7561-7
Clinical Analysis of Thyroid Cancer in Adult Patients Exposed to Ionizing Radiation due to the Chernobyl Nuclear Accident: 5-Year Comparative Investigations Based on the Results of Surgical Treatment
Sergiy M. Cherenko (2004)
10.1016/S0531-5131(03)01141-5
The Chernobyl Tissue Bank—integrating international research on thyroid cancer
G. Thomas (2003)
10.1080/0955300031000114729
Risk coefficients for childhood cancer after intrauterine irradiation: a review
R. Wakeford (2003)
10.1016/S1470-2045(02)00727-1
Chernobyl-related ionising radiation exposure and cancer risk: an epidemiological review.
K. Moysich (2002)
10.1007/BF03178458
Solid cancer risks from radiation exposure for the Australian population
K. Wise (2009)
10.1016/j.icrp.2007.10.010
Annex B and All references
Icrp (2007)
10.17116/patol201577210-15
[Molecular mechanisms of lung cancer development at its different stages in nuclear industry workers].
G. Rusinova (2015)
10.1016/j.jenvrad.2008.11.008
Radionuclides in cigarettes may lead to carcinogenesis via p16(INK4a) inactivation.
Robyn L. Prueitt (2009)
10.1007/174_2011_491
Radiation Risk Associated with Lung Cancer Screening
Cornelia Schaefer-Prokop (2011)
10.1007/s00411-012-0441-x
A method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure
L. Walsh (2013)
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