Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Metabolic Effects Of Weight Loss In Obese Subjects: Changes In Plasma Substrate Levels, Insulin And Growth Hormone Responses

R. Kalkhoff, H. Kim, J. Cerletty, C. Ferrou
Published 1971 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Oral glucose tolerance and intravenous tolbutamide, glucagon and insulin tolerance were assessed in six obese patients before and after an average weight loss of eighty-five pounds and a reduction from 83 to 27 per cent above ideal body weight. Results were compared to ten nonobese subjects of similar age. Before treatment fasting plasma glucose, free fatty acids and immunoreactive insulin exceeded normal levels. Total plasma alpha-amino acid nitrogen levels were unaffected by obesity. Post-challenge insulin responses during the first three tolerance tests were two to four-fold above control responses, and increments of immunoreactive growth hormone during insulin tolerance were subnormal in the obese. After weight reduction only minor differences in mean yjilues existed between obese and control groups. These findings indicate that disturbances in fasting plasma substrate levels as well as plasma insulin and growth hormone responses fii obese individuals are reversible after substantial weight reduction.
This paper references
10.5555/URI:PII:0022214364900332
STUDIES OF INSULIN AND GROWTH HORMONE SECRETION IN HUMAN OBESITY.
P. Beck (1964)
10.1172/JCI104676
Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinism.
D. Rabinowitz (1962)
Secretion of human growth hormone: physiologic and experimental modification.
J. Roth (1963)
Experimental obesity in man.
E. Sims (1968)
H u m a n growth hormone. Clinical measurement, response to hypoglycemia and suppression by glucocorticoids. New Eng
A G Frantz (1964)
10.2337/diab.16.9.666
Exaggerated Insulin Response to Glucagon in Simple Obesity
A. Benedetti (1967)
Effect of weight reduction, triiodothyronine, and diethylstilbesterol on growth h o r m o n e in obesity
O JHLONDON (1969)
G r o w t h h o r m o n e secretion in subjects with and without obesity. Physiopathology of Adipose Tissue
G Tchobroutsky (1969)
10.1016/S0140-6736(65)91026-3
CRITICAL FACTORS IN EXCESSIVE SERUM-INSULIN RESPONSE TO GLUCOSE. OBESITY IN MATURITY-ONSET DIABETES AND GROWTH HORMONE IN ACROMEGALY.
J. Karam (1965)
An automated determination of glucose utilizing a glucose oxidase-peroxidase system.
J. B. Hill (1961)
T h e glucose fatty acid cycle i n obesity and maturity onset diabetes mellitus
C N Hales (1965)
COLORIMETRIC DETERMINATION OF FREE FATTY ACIDS IN BIOLOGICAL FLUIDS.
K. Itaya (1965)
10.1172/JCI105705
The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity.
L. Salans (1968)
10.1016/B978-1-4831-9825-5.50005-1
The growth-promoting and anti-insulin actions of somatotropin.
W. Daughaday (1966)
T h e interaction of diabetes and obesity on the regulation of basal lipolysis in man
J D Porte (1969)
10.1056/NEJM196606022742205
Effect of glucocorticoids on plasma insulin.
M. Perley (1966)
10.1038/2031141A0
A Sensitive Double Antibody Immunoassay for Human Growth Hormone in Plasma
DON S. Schalch (1964)
10.1172/JCI105534
Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus.
H. Seltzer (1967)
10.1172/JCI103259
A relation between non-esterified fatty acids in plasma and the metabolism of glucose.
V. Dole (1956)
10.2337/diab.15.12.867
Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects
M. Perley (1966)
10.2337/diab.17.7.422
Glucose-Fatty Acid Interactions in the Rat Diaphragm in Vivo
G. Schonfeld (1968)
10.1016/0026-0495(67)90076-5
Effect of arginine on serum levels of insulin and growth hormone in obese subjects.
G. Copinschi (1967)
Plasma a m i n o acid levels and insulin secretion in obesity. N e w Eng
G PFELI (1969)
10.1016/s0021-9258(18)55653-2
Effect of cortisone upon rates of glucose production and oxidation in the rat.
I. D. Welt (1952)
10.2337/diab.12.3.197
Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay
J. Karam (1963)
10.2337/diab.18.3.153
Relative Effects of Pregnancy, Human Placental Lactogen and Prednisolone on Carbohydrate Tolerance in Normal and Subclinical Diabetic Subjects
R. Kalkhoff (1969)
10.7326/0003-4819-71-4-833
Metabolic consequences of obesity.
W. Bortz (1969)
10.2337/diab.12.2.115
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
C. R. Morgan (1963)
The sugar transport system in striated muscle. Effect of growth hormone, hydrocortisone and alloxan diabetes.
F. Riddick (1962)



This paper is referenced by
10.1016/S0025-7125(16)30696-4
Endocrine aspects of obesity.
A. Glass (1989)
10.1056/NEJM197110072851511
Obesity and hyperinsulinism.
T. Merimee (1971)
10.11213/TONYOBYO1958.18.332
肥満者のカロリー制限と血清Lecithin-Cholesterol Acyltransferase活性について
玲子 斎藤 (1975)
10.1016/S0300-595X(76)80024-2
Obesity: changes in lipid metabolism and the role of insulin.
P. Nestel (1976)
10.3109/09637487509144278
Diet Therapy in Obese Diabetics
B. F. Clarke (1975)
10.1007/BF01228132
Gastric inhibitory polypeptide (GIP) and insulin in obesity: II. Reversal of increased response to stimulation by starvation or food restriction
B. Willms (2005)
10.1111/j.1464-5491.1994.tb00369.x
Obesity Associated Insulin Resistance Occurs in Hypopituitary Subjects
R. Page (1994)
10.1016/0026-0495(94)90212-7
Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects.
A. Andreotti (1994)
10.1007/BF02581094
Effects of fat mass reduction by dieting and by lipectomy on carbohydrate metabolism in obese patients
G. Enzi (2007)
10.1016/0026-0495(75)90051-7
Effects of mazindol on carbohydrate and insulin metabolism in obesity.
L. Harrison (1975)
10.2337/diab.25.12.1154
The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes
J. Olefsky (1976)
10.2337/diacare.7.6.520
Normalization of Insulin Sensitivity in Type I Diabetic Subjects by Physical Training During Insulin Pump Therapy
H. Yki-Järvinen (1984)
10.1136/pgmj.67.785.230
Hypertension.
G. W. Ching (1991)
10.1007/BF00440500
Changes in parameters appertaining to lipolysis in obese children during a weight-reducing regimen
U. Spahn (1973)
10.1080/003655902320783827
Calculated Fast-growing Benign Prostatic Hyperplasia
J. Hammarsten (2002)
10.1016/0026-0495(90)90257-D
Impaired plasma catecholamine response to submaximal treadmill exercise in obese women.
A. B. Gustafson (1990)
10.1016/0002-9343(83)90654-X
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus.
R. DeFronzo (1983)
10.11405/NISSHOSHI1964.77.927
男性肥満者における体重減少が血清トランスアミナーゼ活性・血清脂質・耐糖能検査に及ぼす影響
通泰 吉次 (1980)
10.1172/JCI107560
Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects.
J. Olefsky (1974)
10.1016/0002-9343(83)90251-6
Role of environmental factors in the development of noninsulin-dependent diabetes mellitus.
E. Horton (1983)
10.2337/diacare.14.6.488
Obesity and Hypertension
H. Dustan (1991)
10.2337/diacare.5.4.370
Response of Non-insulin-dependent Diabetic Patients to an Intensive Program of Diet and Exercise
R. James Barnard (1982)
10.1507/ENDOCRINE1927.62.2_82
正常人および肥満者における合成hp GRF-44の成長ホルモン分泌に関する研究
T. Shimizu (1986)
10.2337/diab.28.4.287
Downregulation of Insulin Receptors in Obese Man
J. Wigand (1979)
10.1016/0026-0495(81)90224-9
Endocrine function in human obesity.
A. Glass (1981)
10.7326/0003-4819-77-5-779
Obesity: a serious symptom.
G. Bray (1972)
10.1093/AJCN/30.5.762
Adipose tissue development in man.
J. Knittle (1977)
10.1210/JCEM-68-6-1106
Circulating amino acids and pancreatic endocrine function after ingestion of a protein-rich meal in obese subjects.
R. Schmid (1989)
10.1002/9780470720462.CH6
Metabolism during normal and diabetic pregnancy and its effect on neonatal outcome.
M. Gillmer (1978)
10.1007/BF02581061
Relationship between carbohydrate tolerance, insulin secretion, and insulin sensitivity of isolated fat cells from obese protodiabetics
B. Schulz (2007)
10.1056/NEJM197110212851718
Effectiveness of condoms in preventing V.D.
Fiumara Nj (1971)
10.1016/0031-9384(86)90177-0
Dependence of food intake on acute and chronic ventricular administration of insulin
C. Plata-salamán (1986)
See more
Semantic Scholar Logo Some data provided by SemanticScholar