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Molecular Mechanisms Regulating Myogenic Determination And Differentiation.

R. L. Perry, M. Rudnick
Published 2000 · Medicine

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The myogenic regulatory factors are necessary for the determination and terminal differentiation of skeletal muscle. Gene targeting experiments have demonstrated that MyoD and Myf5 are important for myogenic determination whereas myogenin and MRF4 are important for terminal differentiation and lineage maintenance. During development, all trunk skeletal muscle is derived from the somite. Two spatially distinct sources of myogenic progenitors are defined by the expression of MyoD or Myf5 and these give rise to hypaxial and epaxial musculature. Both in vivo and in vitro analyses have provided a detailed picture regarding the molecular events controlling lineage determination, cell migration, terminal differentiation and tissue repair. Signal transduction pathways regulating cell cycle, protein-protein interactions and myogenic factor gene activation are implicated in the regulation of myogenesis. Recent experiments examining the origin and stem-cell capacity of satellite cells suggest that these cells may originate from the vascular system, are multipotential and may be useful for the treatment of several degenerative diseases.
This paper references
10.1128/MCB.18.9.4994
Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation
A. Song (1998)
10.1074/JBC.275.7.4545
Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo *
F. Naya (2000)
10.1073/PNAS.96.5.2077
Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.
B. Jiang (1999)
MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids.
P. Woloshin (1995)
10.1101/GAD.13.24.3171
From insect eye to vertebrate muscle: redeployment of a regulatory network.
F. Relaix (1999)
Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently.
Y. Wang (1997)
10.1006/DBIO.1996.0097
Satellite cell proliferative compartments in growing skeletal muscles.
E. Schultz (1996)
10.1006/EXCR.1995.1054
Differences in the developmental fate of cultured and noncultured myoblasts when transplanted into embryonic limbs.
J. Dimario (1995)
10.1016/0092-8674(89)90434-0
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
C. Murre (1989)
10.1128/MCB.12.1.266
The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.
J. J. Schwarz (1992)
Location and growth of epaxial myotome precursor cells.
W. Denetclaw (1997)
10.1016/S0092-8674(00)80571-1
Generic Signals and Specific Outcomes Signaling through Ca2+, Calcineurin, and NF-AT
G. Crabtree (1999)
10.1016/0092-8674(87)90585-X
Expression of a single transfected cDNA converts fibroblasts to myoblasts
R. Davis (1987)
10.1016/0092-8674(89)90682-X
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
C. Murre (1989)
10.1083/JCB.132.4.657
Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis
V. Andrés (1996)
10.1128/MCB.17.2.584
Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.
J. L. Lenormand (1997)
10.1128/MCB.16.12.7043
Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation.
S. Skapek (1996)
10.1126/science.283.5401.534
Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.
C. R. Bjornson (1999)
The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos.
W. Denetclaw (2000)
10.1101/GAD.9.23.2911
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
A. Münsterberg (1995)
10.1126/SCIENCE.286.5445.1738
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
C. Rommel (1999)
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD.
R. Kopan (1994)
Colmenares : Mice lacking the ski proto - oncogene have defects in neurulation , craniofacial patterning , and skeletal muscle development
G Cossu (1997)
Christ & K . Patel : A molecular mechanism enabling continuous embryonic muscle growth : a balance between proliferation and differentiation
M Maroto (1999)
10.1074/jbc.272.10.6653
The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways*
S. A. Coolican (1997)
10.1016/S0168-9525(98)01438-3
Conjunction dysfunction: CBP/p300 in human disease.
R. Giles (1998)
10.1006/DBIO.1997.8670
Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.
J. K. Yoon (1997)
10.1083/JCB.128.4.563
Myogenin is required for late but not early aspects of myogenesis during mouse development
J. Venuti (1995)
Origin of satellite cells in avian skeletal muscles.
O. Armand (1983)
The role of SF/HGF and c-Met in the development of skeletal muscle.
S. Dietrich (1999)
10.1002/j.1460-2075.1990.tb08179.x
Myf‐6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
T. Braun (1990)
Cossu: Skeletal myogenic progenitors originating from embryonic dorsal aorta coexpress endothelial and myogenic markers and contribute to postnatal muscle growth and regeneration
De Angelis (1999)
10.1101/gad.4.8.1450
A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
D. Edmondson (1990)
10.1016/0092-8674(92)90187-H
Functional antagonism between c-Jun and MyoD proteins: A direct physical association
E. Bengal (1992)
10.1016/0092-8674(89)90583-7
Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD
W. Wright (1989)
10.1073/PNAS.96.25.14482
Hematopoietic potential of stem cells isolated from murine skeletal muscle.
K. Jackson (1999)
10.1111/j.1749-6632.1998.tb09894.x
Age‐associated Changes in the Response of Skeletal Muscle Cells to Exercise and Regeneration a
M. Grounds (1998)
10.1038/363079A0
Repression of c-fos promoter by MyoD on muscle cell differentiation
D. Trouche (1993)
10.1128/MCB.12.9.3665
Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.
D. Edmondson (1992)
10.1016/S0070-2153(08)60758-9
The birth of muscle progenitor cells in the mouse: spatiotemporal considerations.
S. Tajbakhsh (2000)
10.1016/S0070-2153(08)60753-X
Evolution and development of distinct cell lineages derived from somites.
B. Brand-Saberi (2000)
10.1016/S0070-2153(08)60757-7
Multiple tissue interactions and signal transduction pathways control somite myogenesis.
A. Borycki (2000)
10.1074/JBC.272.38.23668
Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase*
X. Wang (1997)
10.1016/0012-1606(78)90251-8
Muscle development in vitro following X irradiation.
M. Friedlander (1978)
Autonomy of differentiation in avian branchial somites and the influence of adjacent tissues.
T. Kenny-Mobbs (1987)
Characterization of the early development of specific hypaxial muscles from the ventrolateral myotome.
Y. Cinnamon (1999)
Vescovi : Turning brain into blood : a hematopoietic fate adopted by adult neural stem cells in vivo
I Weissman (1999)
Jacks : The retinoblastoma gene family in differentiation and development
M Tiainen (1999)
Zorzano: Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells
(1996)
Lbx1 is required for muscle precursor migration along a lateral pathway into the limb.
M. K. Gross (2000)
10.1038/386296A0
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
J. Han (1997)
10.1038/384266A0
Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice
S. Tajbakhsh (1996)
10.1073/PNAS.90.11.5242
Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.
O. Pourquié (1993)
The role of Lbx1 in migration of muscle precursor cells.
H. Brohmann (2000)
10.1128/MCB.17.9.5236
Transient expression of a winged-helix protein, MNF-beta, during myogenesis.
Q. Yang (1997)
10.1016/S0092-8674(00)80190-7
Ectopic Pax-3 Activates MyoD and Myf-5 Expression in Embryonic Mesoderm and Neural Tissue
M. Maroto (1997)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)
10.1128/MCB.20.9.3256-3265.2000
Dual Control of Muscle Cell Survival by Distinct Growth Factor-Regulated Signaling Pathways
M. Lawlor (2000)
10.1038/362165A0
Myoblasts transferred to the limbs of embryos are committed to specific fibre fates
J. DiMario (1993)
10.1006/DBIO.1995.1257
The distal human myoD enhancer sequences direct unique muscle-specific patterns of lacZ expression during mouse development.
A. Faerman (1995)
10.1073/PNAS.92.10.4646
Two nuclear localization signals present in the basic-helix 1 domains of MyoD promote its active nuclear translocation and can function independently.
M. Vandromme (1995)
10.1038/364501A0
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
P. Hasty (1993)
10.1128/MCB.19.1.21
Regulation of the MEF2 Family of Transcription Factors by p38
M. Zhao (1999)
10.1038/13843
Early specification of limb muscle precursor cells by the homeobox gene Lbx1h
K. Schäfer (1999)
Wold : Single - cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells
L Megeney (1997)
10.1126/science.7863328
Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase
S. Skapek (1995)
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite.
C. Marcelle (1997)
10.1006/DBIO.1997.8657
Persistent expression of MNF identifies myogenic stem cells in postnatal muscles.
D. Garry (1997)
10.1006/DBIO.1995.1290
The regulation of MyoD gene expression: conserved elements mediate expression in embryonic axial muscle.
A. Asakura (1995)
10.1016/0012-1606(92)90221-2
Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo.
K. Hannon (1992)
10.1034/j.1399-0004.2000.570103.x
The molecular regulation of myogenesis
L. Sabourin (2000)
Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice.
A. Rawls (1998)
10.1016/0014-4827(85)90187-9
Emergence of TPA-resistant 'satellite' cells during muscle histogenesis of human limb.
G. Cossu (1985)
Leibovitch: MyoD binds to Mos and inhibits the Mos/MAP kinase pathway
B Solhonne (1999)
Myogenesis in paraxial mesoderm: preferential induction by dorsal neural tube and by cells expressing Wnt-1.
H. Stern (1995)
10.1128/MCB.17.8.4750
Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD.
Y. Kong (1997)
10.1016/S0092-8674(00)81688-8
Signaling—2000 and Beyond
T. Hunter (2000)
10.1126/SCIENCE.286.5440.790
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.
H. D. Youn (1999)
10.1002/j.1460-2075.1989.tb03429.x
A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.
T. Braun (1989)
10.1073/PNAS.93.9.4355
ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.
C. Lechner (1996)
10.1073/PNAS.87.3.1089
Herculin, a fourth member of the MyoD family of myogenic regulatory genes.
J. Miner (1990)
10.1126/SCIENCE.2174572
Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.
T. Blackwell (1990)
10.1006/DBIO.2000.9621
Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4.
M. R. Valdez (2000)
10.1083/JCB.144.4.631
Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle
L. Sabourin (1999)
10.1073/PNAS.95.24.14179
An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.
B. Jiang (1998)
Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.
M. Goulding (1994)
10.1128/MCB.19.7.5073
Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival
Y. Fujio (1999)
Embryonic activation of the myoD gene is regulated by a highly conserved distal control element.
D. J. Goldhamer (1995)
Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene.
F. Naya (1999)
10.1016/0955-2235(94)90014-0
The human and mouse fibroblast growth factor 6 (FGF6) genes and their products: possible implication in muscle development.
F. Coulier (1994)
10.1016/0012-1606(92)90107-R
Temporal appearance of satellite cells during myogenesis.
J. L. Feldman (1992)
10.1002/j.1460-2075.1989.tb08535.x
Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products.
T. Braun (1989)
10.1146/ANNUREV.CELLBIO.14.1.167
Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins.
B. Black (1998)
Vinals , X . Testar , M . Palacin & A . Zorzano : Phosphatidylinositol 3 - kinase inhibitors block differentiation of skeletal muscle cells
S Coolican (1996)
Mol Cell Biol
(1996)
Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.
B. Williams (1994)
Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos.
M. Pownall (1996)
Genetics of muscle determination and development.
H. Arnold (2000)
10.1016/0925-4773(95)00451-3
Complementary and combinatorial patterns of Notch gene family expression during early mouse development
R. Williams (1995)
10.1101/GAD.12.3.290
Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression.
R. Reshef (1998)
10.1016/0092-8674(92)90142-Y
Muscle fiber pattern is independent of cell lineage in postnatal rodent development
S. Hughes (1992)
10.1038/383407A0
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
C. Chiang (1996)
10.1101/GAD.3.12B.2050
Identification of MRF4: a new member of the muscle regulatory factor gene family.
S. Rhodes (1989)
Activation of different myogenic pathways: myf-5 is induced by the neural tube and MyoD by the dorsal ectoderm in mouse paraxial mesoderm.
G. Cossu (1996)
Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.
M. Ikeya (1998)
10.1016/0012-1606(91)90083-F
Skeletal muscle satellite cell diversity: satellite cells form fibers of different types in cell culture.
J. L. Feldman (1991)
The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation.
P. M. Rong (1992)
MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle.
B. Kablar (1997)
10.1083/JCB.149.2.281
P21 and Retinoblastoma Protein Control the Absence of DNA Replication in Terminally Differentiated Muscle Cells
A. Mal (2000)
10.1083/JCB.113.6.1255
The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development
E. Bober (1991)
10.1016/1050-1738(92)90041-P
Commitment and differentiation of cardiac myocytes.
J. Litvin (1992)
10.1093/emboj/18.24.6983
Direct inhibition of G1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation
J. Zhang (1999)
10.1126/SCIENCE.286.5440.785
Neuronal activity-dependent cell survival mediated by transcription factor MEF2.
Z. Mao (1999)
10.1006/DBIO.1997.8721
Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.
D. Cornelison (1997)
10.1128/MCB.19.6.4028
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
S. Yang (1999)
10.1016/S0925-4773(98)00066-5
The origin and fate of pioneer myotomal cells in the avian embryo
N. Kahane (1998)
10.1074/jbc.271.32.19146
Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells*
P. Kaliman (1996)
Stavnezer : The ski oncogene induces muscle differentiation in quail embryo
M Berk (1989)
Myogenic Determination and Differentiation 763 sclerotomal induction by a hedgehog homologue
S Dietrich
10.1002/j.1460-2075.1995.tb07101.x
Inactivation of Myf‐6 and Myf‐5 genes in mice leads to alterations in skeletal muscle development.
T. Braun (1995)
10.1038/364532A0
Myogenin gene disruption results in perinatal lethality because of severe muscle defect
Y. Nabeshima (1993)
10.1006/DBIO.1997.8624
Developmental potential of rat L6 myoblasts in vivo following injection into regenerating muscles.
C. Pin (1997)
10.1101/GAD.6.4.676
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.
L. Li (1992)
10.1073/PNAS.100501197
Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF.
D. Garry (2000)
10.1016/0092-8674(89)90291-2
The ski oncogene induces muscle differentiation in quail embryo cells
C. Colmenares (1989)
10.1006/DBIO.1999.9565
A new look at the origin, function, and "stem-cell" status of muscle satellite cells.
P. Seale (2000)
10.1126/SCIENCE.3175662
MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.
S. Tapscott (1988)
10.1038/379823A0
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin
Y. Wang (1996)
10.1006/EXCR.1996.0122
FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells.
S. Pizette (1996)
Lassar : pRb is required for MEF 2 - depedent gene expression as well as cell - cycle arrest during skeletal muscle differentiation
S Rao (1999)
10.1016/0092-8674(93)90110-C
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
Wei Gu (1993)
10.1016/0092-8674(94)90008-6
Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
R. Johnson (1994)
Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse.
G. Daston (1996)
10.1016/S0955-0674(99)00036-8
MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation.
F. Naya (1999)
10.1016/0012-1606(92)90068-R
Myogenic cell lineages.
F. Stockdale (1992)
10.1006/DBIO.1999.9284
The transition from proliferation to differentiation is delayed in satellite cells from mice lacking MyoD.
Z. Yablonka-Reuveni (1999)
10.1210/MEND.13.7.0305
The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.
P. Bailey (1999)
10.1006/DBIO.1998.9126
Myogenic determination occurs independently in somites and limb buds.
B. Kablar (1999)
10.1210/ENDO.139.4.5950
Mitogen-activated protein kinase kinase (MEK) activity is required for inhibition of skeletal muscle differentiation by insulin-like growth factor 1 or fibroblast growth factor 2.
C. Weyman (1998)
10.1101/GAD.9.11.1388
Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.
W. Zhang (1995)
10.1002/BIES.950170306
The MyoD family of transcription factors and skeletal myogenesis
M. Rudnicki (1995)
10.1126/science.273.5273.359
Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation
J. Wang (1996)
Genes Dev
(1999)
Bengal : p 38 mitogen - activated protein kinase pathway promotes skeletal muscle differentiation
X Wang (1999)
10.1038/341303A0
Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis
D. Sassoon (1989)
10.1006/DBIO.1995.1218
Slow and fast muscle fibers are preferentially derived from myoblasts migrating into the chick limb bud at different developmental times.
J. Van Swearingen (1995)
10.1016/0092-8674(89)90935-5
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
A. Lassar (1989)
Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages.
M. Teillet (1998)
10.1016/S1097-2765(00)80383-4
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program.
V. Sartorelli (1999)
10.1016/S0959-437X(97)80005-6
Cell cycle exit upon myogenic differentiation.
K. Walsh (1997)
Chatila : Ca 2 + - dependent gene expression mediated by MEF 2 transcription factors
D Trouche (2000)
The satellite cell and muscle regeneration
R. Bischoff (1994)
10.1128/MCB.19.8.5785
NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
D. Guttridge (1999)
10.1002/(SICI)1097-0177(199607)206:3<291::AID-AJA6>3.0.CO;2-D
Gene targeting the myf‐5 locus with nlacZ reveals expression of this myogenic factor in mature skeletal muscle fibres as well as early embryonic muscle
S. Tajbakhsh (1996)
10.1093/emboj/16.23.7054
BMK1/ERK5 regulates serum‐induced early gene expression through transcription factor MEF2C
Y. Kato (1997)
Synergistic interactions between bFGF and a TGF-beta family member may mediate myogenic signals from the neural tube.
H. Stern (1997)
10.1016/0012-1606(92)90106-Q
Skeletal muscle satellite cells appear during late chicken embryogenesis.
R. Hartley (1992)
10.1038/NM1297-1337
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
Margaret A. Goodell (1997)
10.1084/JEM.183.4.1797
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
M. Goodell (1996)
10.1038/376768A0
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
F. Bladt (1995)
signal - related kinase activation
J Han (1995)
The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development.
N. Kahane (1998)
Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.
A. Bendall (1999)
10.1007/s004290050237
Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice
R. Bittner (1999)
10.1083/JCB.135.2.441
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle
B. Novitch (1996)
10.1126/SCIENCE.8197461
Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.
J. Schneider (1994)
10.1074/JBC.271.9.5258
Physical Interaction between the Mitogen-responsive Serum Response Factor and Myogenic Basic-Helix-Loop-Helix Proteins (*)
R. Groisman (1996)
10.1016/S0070-2153(08)60755-3
Sclerotome induction and differentiation.
J. Dockter (2000)
10.1101/GAD.13.2.213
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
P. Zhang (1999)
10.1083/JCB.142.6.1447
The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle Cells
M. Kitzmann (1998)
Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome.
A. Patapoutian (1995)
The dorsal neural tube organizes the dermamyotome and induces axial myocytes in the avian embryo.
M. S. Spence (1996)
10.1101/GAD.13.24.3231
Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.
T. Heanue (1999)
Coulier , D . Birnbaum & O . deLapeyriere : FGF 6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells
T Floss (1996)
Notch2: a second mammalian Notch gene.
G. Weinmaster (1992)
Sonic hedgehog controls epaxial muscle determination through Myf5 activation.
A. Borycki (1999)
10.1128/MCB.19.11.7621
p57Kip2 Stabilizes the MyoD Protein by Inhibiting Cyclin E-Cdk2 Kinase Activity in Growing Myoblasts
E. Reynaud (1999)
10.1038/sj.onc.1203244
The retinoblastoma gene family in differentiation and development
M. Lipinski (1999)
Myogenic specification in somites: induction by axial structures.
N. Buffinger (1994)
10.1006/DBIO.1998.9050
Apoptosis of epaxial myotome in Danforth's short-tail (Sd) mice in somites that form following notochord degeneration.
A. Asakura (1998)
10.1126/SCIENCE.279.5356.1528
Muscle regeneration by bone marrow-derived myogenic progenitors.
G. Ferrari (1998)
10.1016/0012-1606(83)90349-4
Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo.
M. Teillet (1983)
10.1128/MCB.13.10.5943
Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain.
S. Hardy (1993)
10.1016/S0092-8674(05)80066-2
FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains
L. Li (1992)
10.1016/0092-8674(91)90620-E
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
A. Lassar (1991)
10.1101/GAD.11.4.436
Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis.
A. Gerber (1997)
10.1126/SCIENCE.286.5440.771
Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein
S. L. Stroschein (1999)
10.1101/GAD.11.16.2029
Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development.
M. Berk (1997)
10.1249/00005768-198910001-00010
Satellite cell behavior during skeletal muscle growth and regeneration.
E. Schultz (1989)
10.1016/S0960-9822(98)70251-9
The importance of timing differentiation during limb muscle development
H. Amthor (1998)
10.1074/jbc.274.31.21908
Calcineurin Is Required for Skeletal Muscle Hypertrophy*
S. Dunn (1999)
10.1074/jbc.272.32.19785
Differential Interactions of Id Proteins with Basic-Helix-Loop-Helix Transcription Factors*
K. Langlands (1997)
10.1016/S0925-4773(98)00046-X
Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb
D. Mennerich (1998)
Rudnicki : A new look at the origin , function , and " stem - cell " status of muscle satellite cells
D Cornelison (2000)
& L . Kedes : Molecular mechanisms of myogenic coactivation by p 300 : direct interaction with the activation domain of MyoD and with the MADS box of MEF 2 C
P Puri (1997)
10.1016/S1097-2765(00)80005-2
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation.
P. L. Puri (1997)
10.1016/0012-1606(84)90237-9
Temporal separation of the migration of distinct myogenic precursor populations into the developing chick wing bud.
J. Seed (1984)
10.1126/SCIENCE.286.5445.1741
Phosphorylation and regulation of Raf by Akt (protein kinase B).
S. Zimmermann (1999)
Direct relationship between the expression of tumor suppressor H19 mRNA and c-mos proto-oncogene during myogenesis.
M. Leibovitch (1995)
10.1387/IJDB.9303352
Apparent normal phenotype of Fgf6-/- mice.
F. Fiore (1997)
10.1101/GAD.10.10.1173
MyoD is required for myogenic stem cell function in adult skeletal muscle.
L. Megeney (1996)
10.1016/0092-8674(92)90507-9
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
T. Braun (1992)
10.1016/S0960-9822(99)80210-3
pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
B. Novitch (1999)
10.1126/SCIENCE.284.5415.770
Notch signaling: cell fate control and signal integration in development.
S. Artavanis-Tsakonas (1999)
10.1101/GAD.12.16.2499
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
E. Chin (1998)
10.1016/S0092-8674(00)81372-0
Uncoupling of Grb2 from the Met Receptor In Vivo Reveals Complex Roles in Muscle Development
F. Maina (1996)
Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.
B. Kablar (2000)
Levrero : p 300 is required for MyoD - dependent cell cycle arrest and muscle - specific gene expression
V Sartorelli (1997)
10.1128/MCB.17.2.1010
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C.
V. Sartorelli (1997)
10.1016/0012-1606(82)90389-X
Spatial analysis of limb bud myogenesis: a proximodistal gradient of muscle colony-forming cells in chick embryo leg buds.
R. Rutz (1982)
10.1126/SCIENCE.276.5317.1404
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.
Q. Lin (1997)
10.1038/387083A0
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
Alexandra C. McPherron (1997)
10.1002/(SICI)1521-1878(200001)22:1<72::AID-BIES12>3.0.CO;2-S
A clock-work somite.
K. J. Dale (2000)
10.1128/MCB.16.10.5302
Expression of E1A in terminally differentiated muscle cells reactivates the cell cycle and suppresses tissue-specific genes by separable mechanisms.
M. Tiainen (1996)
10.1139/O95-080
Determination versus differentiation and the MyoD family of transcription factors.
L. Megeney (1995)
10.1006/DBIO.1995.0004
Myogenin's functions do not overlap with those of MyoD or Myf-5 during mouse embryogenesis.
A. Rawls (1995)
Determination of somite cells: independence of cell differentiation and morphogenesis.
H. Aoyama (1988)
10.1007/s004410051277
Myotome formation: a multistage process
C. Kalcheim (1999)
Harel-Bellan: Repression of the c-fos promoter by MyoD on muscle cell differentiation
P Leibovitch (1993)
10.1126/science.7863327
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
O. Halevy (1995)
Rudnicki : The molecular regulation of myogenesis
D Garry (2000)
p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene expression
P Puri (1997)
10.1016/S0092-8674(00)81291-X
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4
O. Pourquié (1996)
10.1016/0092-8674(95)90139-6
Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
J. Molkentin (1995)
MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice.
T. Braun (1994)
The embryonic origin of muscle
S. Hauschka (1994)
10.1074/JBC.274.8.5193
p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation
A. Zetser (1999)
10.1128/MCB.15.10.5205
Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors.
Y. Kong (1995)
10.1083/JCB.147.4.869
Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration
L. De Angelis (1999)
10.1016/0092-8674(95)90401-8
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
C. Marshall (1995)
10.1016/0092-8674(94)90009-4
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
C. Fan (1994)
10.1016/0092-8674(92)90508-A
Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
M. Rudnicki (1992)
The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb.
D. Houzelstein (1999)
Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning.
E. Hirsinger (1997)
10.14670/HH-15.649
Skeletal muscle development in the mouse embryo.
B. Kablar (2000)
Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5.
S. Tajbakhsh (1998)
A molecular mechanism enabling continuous embryonic muscle growth - a balance between proliferation and differentiation.
H. Amthor (1999)
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo.
M. Ott (1991)
10.1128/MCB.17.7.3547
Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis.
M. B. Ramocki (1997)
Two myogenic lineages within the developing somite.
C. Ordahl (1992)
10.1128/MCB.18.1.69
Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2
B. Black (1998)
Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo.
O. Delapeyrière (1993)
10.1074/jbc.275.1.197
Ca2+-dependent Gene Expression Mediated by MEF2 Transcription Factors*
F. Blaeser (2000)
10.1002/(SICI)1521-1878(199805)20:5<357::AID-BIES1>3.0.CO;2-L
Knowing chops from chuck: roasting myoD redundancy.
C. Ordahl (1998)
10.1038/43919
Dystrophin expression in the mdx mouse restored by stem cell transplantation
E. Gussoni (1999)
10.1128/MCB.14.8.5259
Ectopic expression of cyclin D1 prevents activation of gene transcription by myogenic basic helix-loop-helix regulators.
S. Rao (1994)
10.1101/GAD.13.17.2196
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling.
K. Luo (1999)
10.1016/S0014-5793(99)01430-1
MyoD binds to Mos and inhibits the Mos/MAP kinase pathway
B. Solhonne (1999)
10.1101/GAD.5.8.1377
Muscle-specific transcriptional activation by MyoD.
H. Weintraub (1991)
10.1073/PNAS.92.8.3219
Control of somite patterning by signals from the lateral plate.
O. Pourquié (1995)
10.1016/S0070-2153(08)60761-9
Determination and morphogenesis in myogenic progenitor cells: an experimental embryological approach.
C. Ordahl (1999)
10.1074/JBC.M907412199
Stabilization of MyoD by Direct Binding to p57Kip2 *
E. Reynaud (2000)
10.1016/0092-8674(93)90725-6
HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id
Lisa A. Neuhold (1993)
10.1016/0092-8674(93)90621-V
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
10.1101/GAD.11.16.2040
A role for FGF-6 in skeletal muscle regeneration.
T. Floss (1997)
10.1139/O98-107
MyoD and Myf-5 define the specification of musculature of distinct embryonic origin.
B. Kablar (1998)
10.1126/SCIENCE.278.5341.1288
Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases.
A. Bennett (1997)
10.1073/PNAS.96.2.552
MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD.
J. Lu (1999)
10.1093/emboj/18.4.926
Coupling of the cell cycle and myogenesis through the cyclin D1‐dependent interaction of MyoD with cdk4
J. Zhang (1999)
Control of dorsoventral pattern in the chick paraxial mesoderm.
S. Dietrich (1997)
10.1128/MCB.15.5.2707
Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis.
P. Naidu (1995)
10.1016/0012-1606(83)90240-3
Regenerating adult chicken skeletal muscle and satellite cell cultures express embryonic patterns of myosin and tropomyosin isoforms.
R. Matsuda (1983)
10.1126/science.7839146
Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
B. Lilly (1995)
10.1016/S0092-8674(00)81692-X
Stem Cells Units of Development, Units of Regeneration, and Units in Evolution
I. Weissman (2000)
Wachtler: Recruitment of bonemarrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice
B Ivanova (1999)
Colmenares: Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development
M Berk (1997)
Wolfman : Mitogen - activated protein kinase kinase ( MEK ) activity is required for inhibition of skeletal muscle differentiation by insulin - like growth factor 1 or fibroblast growth factor 2
A Bennett (1998)
10.1016/S0012-1606(05)80014-4
Expression of the muscle regulatory factor MRF4 during somite and skeletal myofiber development.
T. Hinterberger (1991)
10.1016/S0092-8674(00)80189-0
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
10.1016/S0092-8674(00)81073-9
Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4
E. Olson (1996)



This paper is referenced by
10.1152/ajpregu.00348.2010
Muscle protein synthesis and gene expression during recovery from aerobic exercise in the fasted and fed states.
M. Harber (2010)
10.1111/j.1750-3639.2002.tb00431.x
The Expression Profile of Myogenic Transcription Factors in Satellite Cells from Denervated Rat Muscle
A. Maier (2002)
10.1046/j.1365-2443.2002.00573.x
Identification of a BMP‐responsive element in Id1, the gene for inhibition of myogenesis
T. Katagiri (2002)
10.1155/2017/2460215
Extremely Low-Frequency Electromagnetic Fields Affect Myogenic Processes in C2C12 Myoblasts: Role of Gap-Junction-Mediated Intercellular Communication
C. Morabito (2017)
10.3390/molecules25092117
Effects of the Combination of β-Hydroxy-β-Methyl Butyrate and R(+) Lipoic Acid in a Cellular Model of Sarcopenia
L. Mannelli (2020)
The Role of Stress Resistance in Cell Transplantation Efficacy for Muscle Regeneration
Joseph B. Vella (2010)
10.21037/ATM.2020.02.32
Rotator cuff muscle stem cells: the double-edged sword in the skeletal muscle.
Yongsoo Lee (2020)
10.1371/journal.pone.0142699
Investigation of the Expression of Myogenic Transcription Factors, microRNAs and Muscle-Specific E3 Ubiquitin Ligases in the Medial Gastrocnemius and Soleus Muscles following Peripheral Nerve Injury
Rebecca Wiberg (2015)
10.1080/10495398.2017.1299744
Short-hairpin Mediated Myostatin Knockdown Resulted in Altered Expression of Myogenic Regulatory Factors with Enhanced Myoblast Proliferation in Fetal Myoblast Cells of Goats
R. Kumar (2018)
10.1007/s00421-017-3749-z
Impact of local heating and cooling on skeletal muscle transcriptional response related to myogenesis and proteolysis
Roksana B Zak (2017)
10.3389/fonc.2020.607196
MicroRNAs in Skeletal Muscle and Hints on Their Potential Role in Muscle Wasting During Cancer Cachexia
G. P. Marceca (2020)
The myokine interleukin-7 may influence differentiation and migration of cultured satellite cells
Henrik Lian (2009)
10.1177/154411130401500504
Zinc finger transcription factors in skeletal development.
B. Ganss (2004)
10.1111/j.1365-2613.2006.00475.x
Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle
R. Carvalho (2006)
10.7150/ijbs.10921
MiR-206, a Key Modulator of Skeletal Muscle Development and Disease
Guoda Ma (2015)
10.7150/jca.25395
Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation
Xinqi Ma (2018)
10.1097/00003086-200202000-00008
Connective tissue progenitors: practical concepts for clinical applications.
G. Muschler (2002)
10.1590/S0100-879X2003001200004
Standard-curve competitive RT-PCR quantification of myogenic regulatory factors in chicken embryos.
L. Alvares (2003)
10.1242/jcs.022566
PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
Mee-Sup Yoon (2008)
10.7150/ijbs.8621
CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
M. Wu (2015)
10.1016/j.bbagrm.2014.07.018
Adipose induces myoblast differentiation and mediates TNFα-regulated myogenesis.
Yanling Wu (2014)
10.1007/s12020-013-0142-5
DNA demethylation enhances myoblasts hypertrophy during the late phase of myogenesis activating the IGF-I pathway
P. Senesi (2013)
10.1155/2015/537853
Postmitotic Expression of SOD1G93A Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation
Martina Martini (2015)
10.1152/AJPCELL.00408.2005
Age-associated decrease in muscle precursor cell differentiation.
S. Lees (2006)
10.1017/S0007114516004591
Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice.
T. Egawa (2017)
10.1006/DBIO.2002.0798
Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR.
R. M. Squillace (2002)
10.1091/MBC.E02-09-0600
Requirement for down-regulation of the CCAAT-binding activity of the NF-Y transcription factor during skeletal muscle differentiation.
A. Gurtner (2003)
10.1083/jcb.200403004
Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation
M. Huh (2004)
10.1038/s41598-017-00099-7
Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
T. Rouaud (2017)
10.1002/mus.20051
Gene transfer into intact fetal skeletal muscle grown in vitro
S. P. Cardoso (2004)
10.1038/sj.cdd.4400930
Apoptosis coincident with the differentiation of skeletal myoblasts is delayed by caspase 3 inhibition and abrogated by MEK-independent constitutive Ras signaling
K. Dee (2002)
10.1186/s13287-020-1587-0
Lack of a skeletal muscle phenotype in adult human bone marrow stromal cells following xenogeneic-free expansion
Dominik Barišić (2020)
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