Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Development Of Novel Flurbiprofen-loaded Solid Self-microemulsifying Drug Delivery System Using Gelatin As Solid Carrier

D. W. Kim, J. H. Kang, D. Oh, C. Yong, H. Choi
Published 2012 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
To develop a novel flurbiprofen-loaded solid self-microemulsifying drug delivery system (solid SMEDDS) with improved oral bioavailability using gelatin as a solid carrier, the solid SMEDDS formulation was prepared by spray-drying the solutions containing liquid SMEDDS and gelatin. The liquid SMEDDS, composed of Labrafil M 1944 CS/Labrasol/Transcutol HP (12.5/80/7.5%) with 2% w/v flurbiprofen, gave a z-average diameter of about 100 nm. The flurbiprofen-loaded solid SMEDDS formulation gave a larger emulsion droplet size compared to liquid SMEDDS. Unlike conventional solid SMEDDS, it produced a kind of microcapsule in which liquid SMEDDS was not absorbed onto the surfaces of carrier but formed together with carrier in it. However, the drug was in an amorphous state in it like conventional solid SMEDDS. It greatly improved the oral bioavailability of flurbiprofen in rats. Thus, gelatin could be used as a carrier in the development of solid SMEDDS with improved oral bioavailability of poorly water-soluble drug.
This paper references
Formulation of an aqueous injection of flurbiprofen.
G. D. Gupta (1997)
10.1016/j.ijpharm.2010.10.045
Effect of process parameters on nanoemulsion droplet size and distribution in SPG membrane emulsification.
D. Oh (2011)
10.1016/j.ijpharm.2010.05.023
Effect of the solid-dispersion method on the solubility and crystalline property of tacrolimus.
J. H. Joe (2010)
10.1016/S0378-5173(02)00003-0
Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation.
S. Nazzal (2002)
10.1016/j.ejpb.2008.05.001
A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs.
T. Yi (2008)
10.3109/03639049809089952
Dissolution profiles of flurbiprofen in phospholipid solid dispersions.
M. Habib (1998)
10.1016/j.ijpharm.2008.05.018
Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of protein drugs: I. Formulation development.
S. V. R. Rao (2008)
10.1016/S0378-5173(99)00080-0
Phospholipid-based microemulsions of flurbiprofen by the spontaneous emulsification process.
K. Park (1999)
10.1016/J.IJPHARM.2006.02.019
Controlled release of a self-emulsifying formulation from a tablet dosage form: stability assessment and optimization of some processing parameters.
S. Nazzal (2006)
10.3109/10717544.2010.509365
Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change
D. Oh (2011)
10.1007/s12272-010-2219-5
Enhanced oral bioavailability of flurbiprofen by combined use of micelle solution and inclusion compound.
S. Chong (2010)
10.1016/j.drudis.2008.04.006
Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms.
B. Tang (2008)
10.1016/j.ejpb.2009.03.001
Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).
P. Balakrishnan (2009)
10.1016/j.ejpb.2009.04.018
Improvement of oral bioavailability of flurbiprofen from flurbiprofen/beta-cyclodextrin inclusion complex by action of cinnarizine.
T. Tokumura (2009)
10.2165/00003088-199528020-00002
Clinical Pharmacokinetics of Flurbiprofen and its Enantiomers
N. M. Davies (1995)
10.1016/j.jcis.2008.10.077
Design and optimization of a new self-nanoemulsifying drug delivery system.
L. Wang (2009)
Notes: Each value represents mean AE SD (n ¼ 6)
10.1080/03639040802488089
Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Vinpocetine
Shu-xia Cui (2009)
10.1016/j.ijpharm.2008.05.015
Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study.
S. V. R. Rao (2008)
10.1016/0378-5173(94)00374-E
Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients
P. Mura (1995)
10.1016/S0378-5173(97)00385-2
In situ gelling and mucoadhesive liquid suppository containing acetaminophen : Enhanced bioavailability
H. Choi (1998)
10.1002/JPS.2600740803
Predictive relationships in the water solubility of salts of a nonsteroidal anti-inflammatory drug.
B. D. Anderson (1985)
10.1023/A:1018927402875
Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain Glycerides
P. Constantinides (2004)
10.1016/S0378-5173(03)00386-7
Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization.
M. Bruschi (2003)
Guiding principles in the use of animals in toxicology [ online ]
B Tang
10.1016/j.ejps.2007.11.001
Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers.
J. Woo (2008)
10.1016/j.ijpharm.2007.12.020
Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray-drying technique.
D. X. Li (2008)
10.1016/j.ijpharm.2010.07.013
Development of novel sibutramine base-loaded solid dispersion with gelatin and HPMC: physicochemical characterization and pharmacokinetics in beagle dogs.
Hyun-Tae Lim (2010)
10.1016/J.EJPB.2004.03.030
Evaluation of the bioavailability of flurbiprofen and its beta-cyclodextrin inclusion complex in four different doses upon oral administration to rats.
Atsushi Muraoka (2004)
10.1016/j.ijpharm.2011.09.007
Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier.
D. Oh (2011)
10.1080/10826079708005547
Assay of Flurbiprofen in Rat Plasma Using HPLC with Fluorescence Detection
Kyung-Mi Park (1997)
10.1016/j.ijpharm.2009.03.008
Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems.
P. Balakrishnan (2009)
10.1016/0378-5173(94)00375-F
Preparation and evaluation of flurbiprofen dry elixir as a novel dosage form using a spray-drying technique
C. Kim (1995)
10.1016/j.ijpharm.2011.05.059
New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs.
Y. Kim (2011)



This paper is referenced by
10.1007/s11095-013-1053-0
In Vitro Digestion of the Self-Emulsifying Lipid Excipient Labrasol® by Gastrointestinal Lipases and Influence of its Colloidal Structure on Lipolysis Rate
S. Fernandez (2013)
10.3109/03639045.2014.971031
Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen
Katja Čerpnjak (2015)
10.1016/j.carbpol.2012.11.105
A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS.
Yuanrui Huang (2013)
10.1016/j.ijpharm.2020.119377
Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets.
J. Mandić (2020)
Self Emulsifying/Microemulsifying Drug Delivery Systems of Low Aqueous Solubility Drug For Oral Administration
(2015)
10.3109/03639045.2013.768632
Solid self-microemulsifying drug delivery system of ritonavir
A. Deshmukh (2014)
10.3390/scipharm85010011
Alginate-Based Composite Sponges as Gastroretentive Carriers for Curcumin-Loaded Self-Microemulsifying Drug Delivery Systems
Arpa Petchsomrit (2017)
10.1080/17425247.2017.1321634
The design and scale-up of spray dried particle delivery systems
Ali Al-Khattawi (2018)
10.1080/2331205X.2018.1480572
Advanced colloidal technologies for the enhanced bioavailability of drugs
Fakhar ud Din (2018)
10.1016/j.jddst.2019.101483
Effect of self-emulsifying phase composition on the characteristics of venlafaxine loaded alginate beads
L. Segale (2020)
10.7324/japs.2018.8605
Effect of Self-Microemulsifying Lipid Formulations on the Dissolution and Compaction Profiles of Tablets Containing Theophylline; a BCS Class I Compound -
Naser M. Y. Hasan (2018)
10.1016/j.ijpharm.2019.05.055
Solidification of carvedilol loaded SMEDDS by swirling fluidized bed pellet coating.
J. Mandić (2019)
10.20530/IJNN_4_1-12
DESIGN AND DEVELOPMENT OF SELF-EMULSIFYING DRUG DELIVERY SYSTEMS NOVEL CARDIOACTIVE N-ACYLHYDRAZONE COMPOUND
Beatriz Zanchetta (2016)
10.1016/S1773-2247(14)50011-1
Effect of Oils and Surfactants on Physicochemical Characterization and in Vitro Dissolution of Glibenclamide From Self-Emulsifying Formulations
F. Shakeel (2014)
10.1208/s12249-019-1550-5
A Rundown Through Various Methods Used in the Formulation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS)
Sharel Rency D. Almeida (2019)
10.1208/s12249-015-0370-5
Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib
D. H. Truong (2015)
Self Micron Emulsifying Drug Delivery Systems (SMEEDS) as a potential drug delivery system - Novel applications and future prespectives - A review
Gritta Sebastain (2016)
10.1080/10717544.2016.1214990
Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view
B. Chatterjee (2016)
10.3390/pharmaceutics12040365
Current Status of Supersaturable Self-Emulsifying Drug Delivery Systems
Heejun Park (2020)
10.3109/02652048.2013.774447
Flurbiprofen-loaded nanoparticles prepared with polyvinylpyrrolidone using Shirasu porous glass membranes and a spray-drying technique: nano-sized formation and improved bioavailability
D. Oh (2013)
10.3109/10717544.2013.853709
Quality by design approach for oral bioavailability enhancement of Irbesartan by self-nanoemulsifying tablets
J. Patel (2014)
10.1016/J.AJPS.2014.05.005
Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability
P. Khadka (2014)
10.1016/j.addr.2018.11.006
Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges.
P. Joyce (2018)
10.1016/j.ijpharm.2017.05.036
Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspective.
J. Mandić (2017)
10.3109/02652048.2012.726280
Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel
Q. Quan (2013)
10.3109/03639045.2015.1122611
Formulation optimization of aprepitant microemulsion-loaded silicated corn fiber gum particles for enhanced bioavailability
S. Kamboj (2016)
10.1007/s40005-016-0299-z
Analysis and optimization of drug solubility to improve pharmacokinetics
Raj Kumar Thapa (2016)
10.1016/J.COLSURFA.2017.10.076
Production, properties, and applications of solid self-emulsifying delivery systems (S-SEDS) in the food and pharmaceutical industries
Antónia Gonçalves (2018)
10.1124/jpet.118.254466
Supersaturated Silica-Lipid Hybrid Oral Drug Delivery Systems: Balancing Drug Loading and In Vivo Performance
Hayley B Schultz (2019)
10.1016/j.colsurfb.2017.09.041
Effect of inorganic mesoporous carriers on 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-loaded solid self-emulsifying drug delivery system: Physicochemical characterization and bioavailability in rats.
D. S. Kim (2017)
10.3109/03639045.2012.752501
Development of flurbiprofen-loaded nanoparticles with a narrow size distribution using sucrose
D. Oh (2014)
10.1007/s11095-013-1107-3
Transforming Lipid-Based Oral Drug Delivery Systems into Solid Dosage Forms: An Overview of Solid Carriers, Physicochemical Properties, and Biopharmaceutical Performance
A. Tan (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar