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Dexamethasone Disodium Phosphate Penetration Into The Human Aqueous Humor After Topical Application

C. Cagini, Francesco Cometa, G. Torroni, A. Pellegrino, R. Pellegrino, G. Cavallini
Published 2016 · Medicine

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ABSTRACT Purpose: To study the amount of steroids that is found in the aqueous humor after topical administration of dexamethasone solution eye-drops and dexamethasone suspension eye-drops. Materials and methods: One hundred seventeen consecutive patients of both genders 18 years or older, candidates for cataract surgery were randomly assigned to one of three groups. Fifty-one patients (group A) received a single instillation of a suspension containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 56 patients (group B) received a single instillation of a solution containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 10 patients (group C), control group, did not receive any drops. Samples were taken immediately before surgery from the anterior chamber and dexamethasone levels were measured using gas chromatography/mass spectrometry. Results: The mean dexamethasone concentrations were 0.56 μM (min 0.00, max 3.25) in group A and 0.15 μM (min 0.00, max 2.93) in group B. Dexamethasone was not detected in samples from group C. Conclusions: Dexamethasone suspension gives concentrations of steroids in the aqueous humor approximately three times higher than with dexamethasone solution drops.
This paper references
10.1002/JPS.2600690407
Effect of particle size on ophthalmic bioavailability of dexamethasone suspensions in rabbits.
R. Schoenwald (1980)
10.1001/ARCHOPHT.1976.03910030459003
Topical corticosteroid therapy and pituitary-adrenal function.
T. Krupin (1976)
10.1136/bjo.76.11.681
Pharmacokinetics of ophthalmic corticosteroids.
C. McGhee (1992)
10.1038/EYE.1990.84
Penetration of topically applied betamethasone sodium phosphate into human aqueous humour
D. Watson (1990)
10.1111/J.1600-0420.2007.00885.X
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.
H. Sigurdsson (2007)
10.1001/ARCHOPHT.1967.00980020236017
Ocular absorption of dexamethasone phosphate disodium by the rabbit.
C. Rosenblum (1967)
Locally administered ocular corticosteroids: benefits and risks
CN McGhee (2002)
Corticosteroid therapy of eye disease
M. Raizman (1996)
Dexamethasone-cyclodextrin-polymer co-complexes in aqueous eye drops. Aqueous humor pharmacokinetics in humans.
J. Kristinsson (1996)
10.1038/eye.1990.70
Penetration of synthetic corticosteroids into human aqueous humour
C. McGhee (1990)
10.1001/ARCHOPHT.1968.03850040176013
Systemic absorption of topical steroids.
P. Burch (1968)
10.1016/S0161-6420(02)01176-4
Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate.
O. Weijtens (2002)
10.1001/ARCHOPHT.1974.03900060389009
Topically applied steroids in corneal disease. IV. The role of drug concentration in stromal absorption of prednisolone acetate.
A. Kupferman (1974)
Prednisolone phosphate penetration into and through the cornea.
K. Green (1974)
10.1089/jop.2007.0117
Pharmacokinetic study of dexamethasone disodium phosphate using intravitreal, subconjunctival, and intravenous delivery routes in rabbits.
K. Hosseini (2008)
10.1016/j.jfo.2011.04.013
[A relevant choice for corticoid eye drops: solution or suspension?].
H. Nourry (2011)
10.1136/bjo.2008.154906
Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance
M. Awan (2009)
10.1002/RCM.1290030105
The analysis of corticosteroid acetates by gas chromatography/negative ion chemical ionization mass spectrometry.
D. Watson (1989)
10.1001/ARCHOPHT.1988.01060130748037
Penetration of topically applied dexamethasone alcohol into human aqueous humor.
D. Watson (1988)
10.1016/J.JFO.2011.04.013
Quel choix pour un collyre de corticoïdes : solution ou suspension ?
H. Nourry (2011)
10.1089/JOP.1990.6.243
Review: systemic absorption of topically applied ocular drugs in humans.
L. Salminen (1990)
10.1001/ARCHOPHT.1996.01100140208016
Corticosteroid therapy of eye disease. Fifty years later.
M. Raizman (1996)
10.1097/00055735-200012000-00016
Ocular complications of topical, peri-ocular, and systemic corticosteroids
M. C. Carnahan (2000)
10.1038/eye.1989.69
Penetration of topically applied prednisolone sodium phosphate into human aqueous humour
C. McGhee (1989)



This paper is referenced by
10.4155/bio-2018-0079
Validation of direct method to quantify dexamethasone in human aqueous humor by LC-MS/MS.
M. Ferreira (2018)
10.17925/eor.2019.13.1.37
Post-cataract Cystoid Macular Oedema Prevention – Update 2019
Andrzej Grzybowski (2019)
10.1007/978-3-319-58290-0
Pharmacologic Therapy of Ocular Disease
S. Whitcup (2017)
10.1007/s00228-020-02863-7
Aqueous humour concentrations after topical apPlication of combinEd levofloxacin-dexamethasone eye dRops and of its single components: a randoMised, assEssor-blinded, parallel-group study in patients undergoing cataract surgery: the iPERME study
M. Figus (2020)
Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
Chad J Pickens (2017)
10.1080/02713683.2018.1446534
Ocular Permeation and Sustained Anti-inflammatory Activity of Dexamethasone from Kaolin Nanodispersion Hydrogel System
A. Pramanik (2018)
10.1016/J.IJPHARM.2016.11.053
Pharmaceutical technology can turn a traditional drug, dexamethasone into a first-line ocular medicine. A global perspective and future trends.
J. R. Villanueva (2017)
10.1016/j.jpba.2017.05.025
A rapid microextraction by packed sorbent − liquid chromatography tandem mass spectrometry method for the determination of dexamethasone disodium phosphate and dexamethasone in aqueous humor of patients with uveitis
F. Bianchi (2017)
10.1007/164_2016_21
Pharmacologic Treatment of Noninfectious Uveitis.
Jared E. Knickelbein (2017)
10.1177/2515841420924304
Comparison of anti-inflammatory effects of eye drops formulations after uncomplicated cataract surgery
C. Cagini (2020)
10.1016/j.carbpol.2020.116764
Thermo- and pH-sensitive glycosaminoglycans derivatives obtained by controlled grafting of poly(N-isopropylacrylamide).
I. Pilipenko (2020)
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