Online citations, reference lists, and bibliographies.
← Back to Search

Dissolution Properties Of Naproxen In Combinations With Polyvinylpyrrolidone

G. Bettinetti, P. Mura
Published 1994 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
Share
AbstractThe effect of the molecular weight of polyvinylpyrrolidone on the solubility and dissolution properties of naproxen using solid dispersions (coevaporates and colyophilized products) and physical mixtures was investigated. Factors such as method of drug incorporation with the polymer and polymer mass fraction influence the dissolution rate of naproxen from both powders and constant surface area discs. The best results were obtained with the colyophilized products at the drug-to-polymer 7:3 weight ratio, in the rank order (most effective to least) K15>K30>lK90 (dispersed amount) and K30>K90>K15 (rotating disc). The physical state of naproxen, i.e. amorphous or crystalline, in solid combinations with polyvinylpyrrolidone was checked by means of X-ray powder diffraction. Drug-polymer interactions in the liquid state were revealed with solubility experiments. Drug-polymer interactions in solid state were demonstrated by combining the X-ray diffraction data with the results of thermal analysis (DSC, TGA...
This paper references



This paper is referenced by
10.1007/s11095-005-2598-3
Interactions of Poly(vinylpyrrolidone) with Ibuprofen and Naproxen: Experimental and Modeling Studies
S. Bogdanova (2005)
10.4172/2167-7689.1000108
Micellar Solubilization in the Formulation Development of Poorly Soluble
N. Maheswari (2013)
10.1016/0378-5173(95)04085-4
Characterization of carbamazepine in systems containing a dissolution rate enhancer
E. O. Machiste (1995)
10.4314/IJHR.V2I2.55401
Dissolution enhancement of drugs. part i: technologies and effect of carriers
V. Saharan (2010)
10.1016/S0378-5173(99)00070-8
Properties of solid dispersions of piroxicam in polyvinylpyrrolidone.
V. Tantishaiyakul (1996)
10.1016/S0928-0987(03)00068-X
Development and characterization of naproxen-chitosan solid systems with improved drug dissolution properties.
P. Mura (2003)
10.1016/S0939-6411(03)00112-7
Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen.
N. Zerrouk (2004)
10.1016/S1773-2247(04)50101-6
Properties of solid dispersion of piroxicam in Pluronic F-98
M. El-Badry (2004)
10.4314/IJHR.V2I3.47904
Dissolution Enhancement of Drugs. Part II: Effect of Carriers
V. Saharan (2009)
10.1016/j.ijpharm.2013.06.082
Gelatine enhances drug dispersion in alginate bilayer film via the formation of crystalline microaggregates.
H. Thu (2013)
Preparation and characterization of etoricoxib-polyethylene glycol 4000 plus polyvinylpyrrolidone K 30 solid dispersions
H. M. Patel (2006)
10.1007/BF03189324
Dissolution kinetics for coprecipitates of diflunisal with PVP K30
C. Rodríguez-Espinosa (2010)
Preparation and characterization of solid dispersions of carvedilol with PVP K30
A. Sharma (2010)
10.1016/j.ejps.2008.08.006
Nanocomposites of 2-arylpropionic acid drugs based on Mg-Al layered double hydroxide for dissolution enhancement.
M. Berber (2008)
10.1016/j.ijpharm.2018.03.061
Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain
D. Belletti (2018)
10.1016/S0040-6031(98)00440-7
Differential scanning calorimetry in compatibility testing of picotamide with pharmaceutical excipients
P. Mura (1998)
10.1016/S0378-5173(02)00664-6
Effect of PVP K-25 on the formation of the naproxen:β-ciclodextrin complex
M. Valero (2003)
10.1016/S0378-5173(97)00107-5
Interactions of naproxen with vinylpyrrolidone and β-cyclodextrin: a fluorimetric study1
I. Vélaz (1997)
10.1021/mp100013p
Theoretical and experimental investigation on the solid solubility and miscibility of naproxen in poly(vinylpyrrolidone).
A. Paudel (2010)
10.1016/J.IJPHARM.2003.07.003
Ternary naproxen:β-cyclodextrin:polyethylene glycol complex formation
M. Valero (2003)
10.1016/0378-5173(94)00374-E
Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients
P. Mura (1995)
10.1016/J.EJPB.2006.01.016
Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone.
E. Karavas (2006)
10.1081/DDC-120003864
Solid Dispersions of Diflunisal–PVP: Polymorphic and Amorphous States of the Drug
M. C. Martínez-Ohárriz (2002)
The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
Siok Yee Chan (2013)
10.1016/S0731-7085(98)00171-X
Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy.
P. Mura (1998)
10.22377/ajp.v10i3.724
Lamotrigine Solid Dispersions for Solubility Enhancement
Arti Mohan (2016)
10.1163/156856209X415774
Preparation and Evaluation of a Contact Lens Vehicle for Puerarin Delivery
J. Xu (2010)
Preparation and characterization of etoricoxib-polyethylene glycol 4000 plus polyvinylpyrrolidone K30 solid dispersions.
B. Suhagia (2006)
10.1002/CEAT.201200510
Solubility of Ibuprofen, Phytosterol, Salicylic Acid, and Naproxen in Aqueous Solutions
Dennis Bolten (2013)
Dissolution Enhancement of Poorly Soluble Drugs by Using Complexation Technique – A Review
S. Kumar (2013)
10.1002/9781119041450.CH12
Role of Polymers in Ternary Drug Cyclodextrin Complexes
Renu Chadha (2015)
10.1016/S0928-0987(01)00093-8
The influence of polyvinylpyrrolidone on naproxen complexation with hydroxypropyl-beta-cyclodextrin.
P. Mura (2001)
See more
Semantic Scholar Logo Some data provided by SemanticScholar