Online citations, reference lists, and bibliographies.
← Back to Search

In Vivo Effects Of Antibodies To Immune Response Gene Products. II. Suppression Of Humoral Immune Responses With Monoclonal Anti-I-A Is Due To Suppressor Cells.

N. Adelman, D. Watling, H. Mcdevitt
Published 1988 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The I region of the murine major histocompatibility complex (H-2) encodes two cell surface glycoprotein complexes (Aα:Aβ and Eα:Eβ) which exert profound control over many immunologic reactions including humoral and cellular responses to a variety of antigens, i.e., Ir gene effects, stimulation in mixed lymphocyte reaction, graft versus host disease, antigen presentation to T cells by macrophages, collaboration between T and B cells and determination of T cell help or suppression [1-13]. In the past few years, several laboratories have reported that antibodies directed against I region gene products (anti-la) are effective in modulating immune responses both in vitro and in vivo [14-32, 48-51]. The ability of anti-la antibodies to alter immune responsiveness was attributed to their interaction with macrophage la antigens, thus masking or sterically hindering la epitopes involved in antigen presentation [16,17, 33-35]. However, other reports have suggested that additional mechanisms may be involved [28, 36-...
This paper references
10.1126/science.163.3872.1207
Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type
H. Mcdevitt (1969)
10.1084/JEM.135.6.1259
GENETIC CONTROL OF THE IMMUNE RESPONSE
H. Mcdevitt (1972)
10.1002/EJI.1830031011
A rapid method for the isolation of functional thymus‐derived murine lymphocytes
M. H. Julius (1973)
10.1084/JEM.139.3.679
ALLOANTISERUM-INDUCED INHIBITION OF IMMUNE RESPONSE GENE PRODUCT FUNCTION
E. Shevach (1974)
10.1084/JEM.142.3.694
Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers
M. Taussig (1975)
10.1084/JEM.142.6.1447
Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L- glutamic acid50-L-tyrosine50 (GT)
P. Debré (1975)
10.1126/SCIENCE.1118728
Inhibition of immune responses in vitro by specific antiserums to Ia antigens.
J. Frelinger (1975)
10.1016/B978-0-12-651050-8.50015-6
THE ROLE OF PRODUCTS OF THE HISTOCOMPATIBILITY GENE COMPLEX IN IMMUNE RESPONSES
D. Katz (1975)
10.1002/EJI.1830060412
Suppressor cell induction in vitro. I. Kinetics of induction of antigen‐specific suppressor cells
S. Kontiainen (1976)
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera.
R. Schwartz (1976)
Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses.
K. Ishizaka (1976)
10.1084/JEM.144.3.713
Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex
T. Tada (1976)
10.1007/978-1-4613-4355-4_85
Antigen specific T cell factors in the genetic control of the immune response to poly(tyr,glu)poly(pro)--poly(lys).
E. Mozes (1976)
10.1111/j.1600-065X.1976.tb00213.x
A Cardinal Role for I‐Region Antigens (Ia) in Immunological Enhancement, and the Clinical Implications
D. A. Davies (1976)
10.1073/PNAS.74.9.3975
Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex.
M. Pierres (1977)
10.1073/PNAS.74.11.5118
Reduction of syngeneic tumor growth by an anti-I-J-alloantiserum.
M. Greene (1977)
10.1016/B978-0-12-483260-2.50051-3
INHIBITORY EFFECT OF ANTI-Ia SERA ON PROLIFERATIVE RESPONSES TO (H,G)-A--L and (Phe,G)-A--L
P. Lonai (1978)
10.1007/978-3-642-67448-8_18
Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.
V. T. Oi (1978)
Function of macrophages in genetic control of immune responsiveness.
A. Rosenthal (1978)
10.1084/JEM.148.4.925
Two-gene control of the expression of a murine Ia antigen
P. Jones (1978)
Structural studies on the murine Ia alloantigens. VI. Evidence that both subunits of the I-A alloantigen are encoded by the I-A subregion.
R. Cook (1979)
10.1084/JEM.149.4.981
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I- A subregion
R. Cook (1979)
10.1038/279437A0
Structural polymorphism of I–E subregion antigens determined by a gene in the H–2K to I–B genetic interval
J. Silver (1979)
10.1084/JEM.152.4.1085
Monoclonal antibody against an Ir gene product?
E. Lerner (1980)
10.1084/JEM.151.1.257
Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30)
S. Broder (1980)
10.1084/JEM.152.4.996
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements
J. Sprent (1980)
10.1073/PNAS.77.4.2178
In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.
D. Meruelo (1980)
Definitive mapping of the immune response gene(s) for (T,G)-A--L to the I-A subregion.
M. Markman (1980)
10.1016/0090-1229(80)90040-9
Mechanisms of regulation of cell-mediated immunity: anti-I-A alloantisera interfere with induction and expression of T-cell-mediated immunity to cell-bound antigen in vivo.
L. Perry (1980)
10.1084/JEM.154.5.1694
In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A
J. Rosenbaum (1981)
T cell subset interactions in the regulation of syngeneic tumor immunity.
L. Perry (1981)
10.1073/PNAS.78.11.7111
In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis.
L. Steinman (1981)
10.1073/PNAS.78.2.1152
Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection.
W. Green (1981)
Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.
K. Ziegler (1981)
Genetic control of the immune response to myoglobins. IV. Inhibition of determinant-specific Ir gene-controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-Ia antibodies.
J. Berzofsky (1981)
10.1084/JEM.153.4.936
Structure of murine Ia antigens. Two dimensional electrophoretic analyses and high pressure liquid chromatography tryptic peptide maps of products of the I-A and I-E subregions and of an associated invariant polypeptide
M. McMillan (1981)
10.1084/JEM.155.2.490
Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex.
J. McNicholas (1982)
Evidence that antisera that react with products of the human HLA-DR locus may block in vitro antigen-induced proliferation by inducing suppression.
A. Muchmore (1982)
Antigen-specific human T lymphocyte clones: mechanisms of inhibition of proliferative responses by xenoantiserum to human nonpolymorphic HLA-DR antigens.
J. Lamb (1982)
10.1084/JEM.155.2.508
Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in A(e):E(a), complex expression causes a corresponding defect in antigen-presenting cell function
L. Matis (1982)
10.1084/JEM.156.2.480
Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies
L. Perry (1982)
10.1084/JEM.158.4.1362
Anti I-A antibody suppresses active encephalomyelitis: treatment model for diseases linked to IR genes
S. Sriram (1983)
10.1084/JEM.158.4.1350
Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies
N. Adelman (1983)
10.1073/PNAS.80.9.2713
In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor.
M. Waldor (1983)
10.1073/PNAS.81.9.2855
Disappearance and reappearance of B cells after in vivo treatment with monoclonal anti-I-A antibodies.
M. Waldor (1984)
10.1002/EJI.1830160506
Ir gene expression on T cells: Effect of a monoclonal antibody directed against I region‐controlled determinants on T cells
J. Yagi (1986)
10.1002/EJI.1830160811
Effect of anti‐Ia treatment on the production of anti‐DNA antibody by NZB mice
D. Klinman (1986)
The effects of an anti-I-Ab antibody on murine host resistance to Listeria monocytogenes.
R. Kurlander (1987)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar