Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Fragility Fracture Risk And Skeletal Muscle Function
F. Pérez-López, I. Ara
Published 2016 · Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Abstract Low-intensity fractures are closely related with age-related musculoskeletal disorders, including osteoporosis, muscle dysfunction and sarcopenia, age-related chronic diseases, and pharmacological treatments. During the last years, a huge amount of information and recommendations has been released in relation to bone metabolism and mineral content. Muscle dysfunction and sarcopenia are highly prevalent during the second half of life, especially in older subjects. The development of sarcopenia may be slowed through healthy lifestyle changes, which include adequate dietary protein, vitamin D and mineral intakes, and regular physical activity. Prevention of falls should be integral, including correction in major involved factors in order to reduce fragility fracture, improve quality of life and appropriately focus clinical and economic resources. Therefore, to obtain better results a global approach is needed to prevent age-related fractures in frail patients that is not only centered on bone metabolism and antiresorptive drugs.
This paper references
Can physical activity prevent physical and cognitive decline in postmenopausal women? A systematic review of the literature.
D. Anderson (2014)
Overdiagnosis of bone fragility in the quest to prevent hip fracture
T. Järvinen (2015)
Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: a randomized clinical trial.
S. Greenspan (2015)
Lifestyle predictors of healthy ageing in men.
M. Södergren (2013)
Muscle fibre type adaptation in the elderly human muscle
J. L. Andersen (2003)
Physical Dimensions of Aging
A. Swank (1996)
Sarcopenia and fragility fractures: molecular and clinical evidence of the bone-muscle interaction.
U. Tarantino (2015)
Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: A 1‐year double‐blind RCT in postmenopausal women
H. Macdonald (2013)
Serum 25 hydroxyvitamin D, bone mineral density and fracture risk across the menopause.
J. Cauley (2015)
Muscle atrophy is not always sarcopenia.
R. Hepple (2012)
Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures
L. Ahmed (2015)
The utility of absolute risk prediction using FRAX® and Garvan Fracture Risk Calculator in daily practice.
T. van Geel (2014)
Adherence to osteoporosis medications.
F. Pérez-López (2012)
Dietary Reference Intakes for Calcium and Vitamin D
D. Viswanath (2012)
Evidence to Support Including Lifestyle Light-Intensity Recommendations in Physical Activity Guidelines for Older Adults
P. Loprinzi (2015)
EXERNET Study Group. Prevalence of overweight and obesity in non-institutionalized people aged 65 or over from Spain: the elderly EXERNET multi-centre study
A Gomez-Cabello (2011)
Bone three-dimensional microstructural features of the common osteoporotic fracture sites.
H. Chen (2014)
Quantifying the magnitude of risk for balance impairment on falls in community-dwelling older adults: a systematic review and meta-analysis.
S. Muir (2010)
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia.
F. Lauretani (2003)
Aging of human muscle: structure, function and adaptability
M. Porter (1995)
Will my patient fall?
D. Ganz (2007)
Effects of Training on Bone Mass in Older Adults
A. Gómez-Cabello (2012)
The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials.
C. Beaudart (2014)
EMAS position statement: Vitamin D and postmenopausal health.
F. Pérez-López (2012)
Physical Dimensions of Aging, 2nd edn. Champaign, IL, USA: Human Kinetics
WW Spirduso (2005)
Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women
K. F. Moseley (2013)
SSRI use and risk of fractures among perimenopausal women without mental disorders
Y. Sheu (2015)
Prevalence of overweight and obesity in non‐institutionalized people aged 65 or over from Spain: the elderly EXERNET multi‐centre study
A. Gómez-Cabello (2011)
Vision and Relevant Risk Factor Interventions for Preventing Falls among Older People: A Network Meta-analysis
Xinyi Zhang (2015)
The Effect of Vitamin D on Falls : A Systematic Review and Meta-Analysis
M. H. Murad (2011)
Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture.
M. Di Monaco (2011)
Osteosarcopenic obesity and fall prevention strategies.
F. Hita-Contreras (2015)
Protein and healthy aging.
D. Paddon-Jones (2015)
Structural and Biomechanical Basis of Sexual Dimorphism in Femoral Neck Fragility Has Its Origins in Growth and Aging
Y. Duan (2003)
[The new dietary reference intakes from the Institute of Medicine for calcium and vitamin D].
S. Atkinson (2011)
The Association of Vitamin D With Femoral Neck Strength: An Additional Evidence of Vitamin D on Bone Health.
H. Kim (2015)
Women with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCT
K. Nishiyama (2012)
The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
R. Rizzoli (2014)
Fat mass influence on bone mass is mediated by the independent association between lean mass and bone mass among elderly women: a cross-sectional study.
A. Gómez-Cabello (2013)
Gender gap in longevity and disability in older persons.
A. Newman (2001)
The effect of vitamin D on falls
M. Murad (2011)
This paper is referenced by
Comorbidity increased the risk of falls in Chinese older adults : a cross-sectional study
Wenhua Bao (2017)
Current imaging techniques in osteoporosis.
J. Carey (2018)
Low bone mineral density in middle-aged women: a red flag for sarcopenia
I. Campodónico (2018)
Osteosarcopenia: A new geriatric syndrome.
E. B. Hassan (2017)
Bioimpedance analysis vs. DEXA as a screening tool for osteosarcopenia in lean, overweight and obese Caucasian postmenopausal females
M. Peppa (2017)
The risks of sarcopenia, falls and fractures in patients with type 2 diabetes mellitus.
C. Sarodnik (2018)
Dynapenia and Sarcopenia During Female Midlife
F. Pérez-López (2017)
Fall prevention in postmenopausal women: the role of Pilates exercise training
F. Hita-Contreras (2016)
Frailty as a Predictor of Future Fracture in Older Adults: A Systematic Review and Meta‐Analysis
K. Chen (2017)
A simple anthropometric tool for the assessment of pre-sarcopenia in postmenopausal women
M. Morosano (2017)