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Strategies For Peptic Ulcer Healing After 1 Week Proton Pump Inhibitor-based Triple Helicobacter Pylori Eradication Therapy In Japanese Patients: Differences Of Gastric Ulcers And Duodenal Ulcers

Toshihisa Takeuchi, Eiji Umegaki, Nozomi Takeuchi, Yukiko Yoda, Yuichi Kojima, Satoshi Tokioka, Kazuhide Higuchi
Published 2012 · Medicine
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Helicobacter pylori (H. pylori) eradication therapy alone is insufficient to ensure healing of large ulcers with H. pylori-positive gastric ulcer (GU). The question of what is the optimum antiulcer treatment following H. pylori eradication therapy has not been fully elucidated. Furthermore, the ulcer healing effects of eradication therapy itself with H. pylori-positive duodenal ulcer (DU) have not been investigated. In GU study, the eradication therapy + proton pump inhibitor (PPI) group (group A) were administered eradication therapy followed by 7 weeks of a PPI, and the eradication therapy + gastroprotective drug (GP) group (group B) eradication therapy followed by 7 weeks of a GP. In DU study, the eradication therapy + PPI group (group C) were administered eradication therapy followed by 5 weeks of a PPI, and the eradication therapy only group (group D) was eradication therapy alone. In GU study, healing rates for ulcer of ≥15 mm in diameter were significant greater in the group A. In DU study, high healing rates were seen both the group C and D. In conclusion, a PPI could significantly heal GU than a GP after eradication therapy in GU. Meanwhile, the eradication alone is sufficient for DU.
This paper references
10.1046/j.1365-2036.2003.01402.x
Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study.
Kazuhide Higuchi (2003)
Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH 1 Study
T Lind (1996)
10.1046/j.1365-2036.1999.00535.x
The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer.
Peter Malfertheiner (1999)
Helicobacter pylori eradication with short-term therapy leads to duodenal ulcer healing without the need for continued acid suppression therapy.
K L Goh (1996)
10.1016/S0140-6736(94)91460-5
Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: randomised controlled trial
Shorland W. Hosking (1994)
10.1046/j.1365-2036.1999.00471.x
The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy.
S. J. O. Veldhuyzen Van Zanten (1999)
10.1007/s00535-007-2076-2
Rebamipide, a gastro-protective and anti-inflammatory drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori in a Japanese population: a randomized, double-blind, placebo-controlled trial
A. Terano (2007)
10.1111/j.1523-5378.1996.tb00027.x
Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study.
T. Lind (1996)
10.1046/j.1365-2036.2003.01744.x
Gastric acid-suppressive therapy and community-acquired respiratory infections.
R. Laheij (2003)
10.1001/jama.296.24.2947
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
10.1046/j.1365-2036.2000.00673.x
Does eradication of Helicobacter pylori alone heal duodenal ulcers?
Zhi-Zheng Ge (2000)
10.1097/00042737-199409000-00004
Short‐term low‐dose triple therapy for the eradication of Helicobacter pylori
Franco Bazzoli (1994)
10.1503/cmaj.082001
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
D. Juurlink (2009)
10.3109/00365521.2010.531485
Comparison of the efficacy of irsogladine maleate and famotidine for the healing of gastric ulcers after Helicobacter pylori eradication therapy: a randomized, controlled, prospective study
Kazunari Murakami (2011)
10.1111/j.1365-2036.2010.04250.x
Clinical trial: irsogladine maleate, a mucosal protective drug, accelerates gastric ulcer healing after treatment for eradication of Helicobacter pylori infection--the results of a multicentre, double-blind, randomized clinical trial (IMPACT study).
H. Hiraishi (2010)
10.1136/gut.41.1.43
Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study.
S. Katherine Lam (1997)
10.1111/j.1440-1746.2010.06232.x
Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist.
Kazuhide Higuchi (2010)
10.1001/jama.292.16.1955
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.
R. Laheij (2004)



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