Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Effect Of Whey Protein On The Proliferation And Differentiation Of Osteoblasts.

R. Xu
Published 2009 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Effects of whey protein on osteoblasts were evaluated. The whey protein was added to the culture medium at concentrations of 0.02 and 0.1 mg/mL. In vitro, whey protein stimulated the proliferation and differentiation of osteoblasts cultured in different concentrations of whey protein. The levels of osteocalcin and insulin-like growth factor-I in the culture medium also increased. Real-time reverse transcription-PCR results showed that the mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL) increased in the cells in a dose-dependent manner, and when the results were expressed as OPG/RANKL ratio, a significant increase could be seen in the 0.1 mg/mL whey protein group. These results showed that the active component in the whey protein plays an important role in bone formation and a potential therapeutic role in osteoporosis by activating osteoblasts.
This paper references



This paper is referenced by
food compositions to stimulate bone formation
B. Rousseau (2012)
10.1016/j.peptides.2017.11.004
Osteoanabolic activity of whey-derived anti-oxidative (MHIRL and YVEEL) and angiotensin-converting enzyme inhibitory (YLLF, ALPMHIR, IPA and WLAHK) bioactive peptides
Masum Pandey (2018)
10.1016/j.jnutbio.2015.11.017
Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation.
M. Oliveira (2016)
10.1016/j.matdes.2019.108408
Novel naturally derived whey protein isolate and aragonite biocomposite hydrogels have potential for bone regeneration
Dhanak Gupta (2020)
10.1039/c3fo60525f
Effects of the amount and source of dietary protein on bone status in rats.
E. Nebot (2014)
Effects of soy protein isolate and milk protein isolate on metabolic health and bone outcomes in sedentary, adolescent male OLETF rats
M. W. Richard (2016)
10.1016/j.chroma.2012.01.011
Applicability of analytical and preparative monolithic columns to the separation and isolation of major whey proteins.
A. Albreht (2012)
10.1002/jbm.a.36754
Novel multicomponent organic-inorganic WPI/gelatin/CaP hydrogel composites for bone tissue engineering.
Michal Dziadek (2019)
10.1007/s00217-016-2710-4
Identification of buffalo casein-derived bioactive peptides with osteoblast proliferation activity
S. Reddi (2016)
10.1089/pho.2010.2841
Low-level laser therapy induces differential expression of osteogenic genes during bone repair in rats.
Elaine Fávaro-Pípi (2011)
10.1016/j.matlet.2019.127115
Novel whey protein isolate-based highly porous scaffolds modified with therapeutic ion-releasing bioactive glasses
M. Dziadek (2020)
10.1039/d0fo00497a
Pea protein-derived tripeptide LRW shows osteoblastic activity on MC3T3-E1 cells via the activation of the Akt/Runx2 pathway.
Harshita Arora (2020)
10.1016/J.APSUSC.2013.03.039
Bio-functionalization of polycaprolactone infiltrated BCP scaffold with silicon and fibronectin enhances osteoblast activity in vitro
Kyung-A Kwak (2013)
10.1007/BF03223347
Health benefits of whey proteins
R. Sharma (2010)
10.3390/foods9101510
Gastrointestinal In Vitro Digests of Infant Biscuits Formulated with Bovine Milk Proteins Positively Affect In Vitro Differentiation of Human Osteoblast-Like Cells
Michela Bottani (2020)
10.1007/s13197-015-1894-0
Emerging trends in nutraceutical applications of whey protein and its derivatives
S. Patel (2015)
10.3168/jds.2017-13119
Application of whey protein isolate in bone regeneration: Effects on growth and osteogenic differentiation of bone-forming cells.
Timothy E L Douglas (2018)
10.1016/J.FBIO.2013.03.008
Casein hydrolysates enhance osteoblast proliferation and differentiation in mouse bone marrow culture
P. Behera (2013)
Semantic Scholar Logo Some data provided by SemanticScholar