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A Review Of The Central Response To Peripheral Nerve Injury And Its Significance In Nerve Regeneration.

C. Engh, B. Schofield
Published 1972 · Biology, Medicine

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✓ Chromatolysis is a morphological term used to describe a sequence of light microscopic changes occurring in the cell bodies (perikarya) of peripheral neurons after injury to their peripherally directed axons. The authors have attempted to interpret the significance of chromatolysis to peripheral nerve regeneration and to describe how central regenerative activity may be affected by peripheral regeneration. Electron microscopic perikaryal changes following peripheral nerve injuries initially appear to be manifestations of a nonspecific cellular insult with possible loss of trophic influence, and secondarily a reflection of neuronal readjustment to a decrease in peripheral axon demands. Sectioning of peripheral axons results initially in decreased perikaryal axonal cytoplasm synthesis. Return of normal and sometimes greater than normal perikaryal cytoplasm production and a return of normal perikaryal morphology are characteristics of the maturation phase of peripheral nerve regeneration and occur only if ...
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