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Zinc Acetate-Mediated Regioselective N-Acylation Of 1,3-Disubstituted Selenoureas

X. Li, Bin Gan, Zhixiang Peng, Zhisheng Mi, Y. Xie
Published 2018 · Chemistry

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N-acetylureas were synthesised regioselectively from 1,3-disubstituted selenoureas and zinc acetate. Regioselectivity was dependent on the pKa of the amine attached to the selenourea and occurred towards the amine with the lower pKa. The approach provided a simple, mild and efficient way to construct various N-acetylureas regioselectively in moderate to good yields (53–88%). A plausible mechanism was proposed for the formation of N-acetylureas.
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