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Nano-Strategies To Fight Multidrug Resistant Bacteria—“A Battle Of The Titans”

P. Baptista, M. McCusker, A. Carvalho, D. A. Ferreira, N. M. Mohan, Marta Martins, A. Fernandes
Published 2018 · Biology, Medicine

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Infectious diseases remain one of the leading causes of morbidity and mortality worldwide. The WHO and CDC have expressed serious concern regarding the continued increase in the development of multidrug resistance among bacteria. Therefore, the antibiotic resistance crisis is one of the most pressing issues in global public health. Associated with the rise in antibiotic resistance is the lack of new antimicrobials. This has triggered initiatives worldwide to develop novel and more effective antimicrobial compounds as well as to develop novel delivery and targeting strategies. Bacteria have developed many ways by which they become resistant to antimicrobials. Among those are enzyme inactivation, decreased cell permeability, target protection, target overproduction, altered target site/enzyme, increased efflux due to over-expression of efflux pumps, among others. Other more complex phenotypes, such as biofilm formation and quorum sensing do not appear as a result of the exposure of bacteria to antibiotics although, it is known that biofilm formation can be induced by antibiotics. These phenotypes are related to tolerance to antibiotics in bacteria. Different strategies, such as the use of nanostructured materials, are being developed to overcome these and other types of resistance. Nanostructured materials can be used to convey antimicrobials, to assist in the delivery of novel drugs or ultimately, possess antimicrobial activity by themselves. Additionally, nanoparticles (e.g., metallic, organic, carbon nanotubes, etc.) may circumvent drug resistance mechanisms in bacteria and, associated with their antimicrobial potential, inhibit biofilm formation or other important processes. Other strategies, including the combined use of plant-based antimicrobials and nanoparticles to overcome toxicity issues, are also being investigated. Coupling nanoparticles and natural-based antimicrobials (or other repurposed compounds) to inhibit the activity of bacterial efflux pumps; formation of biofilms; interference of quorum sensing; and possibly plasmid curing, are just some of the strategies to combat multidrug resistant bacteria. However, the use of nanoparticles still presents a challenge to therapy and much more research is needed in order to overcome this. In this review, we will summarize the current research on nanoparticles and other nanomaterials and how these are or can be applied in the future to fight multidrug resistant bacteria.
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10.1007/s10904-020-01601-x
Fabrication of Ag NPs/Zn-MOF Nanocomposites and Their Application as Antibacterial Agents
Reza Sacourbaravi (2020)
10.1515/gps-2020-0043
In vitro biological activity of Hydroclathrus clathratus and its use as an extracellular bioreductant for silver nanoparticle formation
Raghad R. Alzahrani (2020)
10.1002/adfm.201908783
Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era
Didem Şen Karaman (2020)
10.26717/BJSTR.2019.13.002353
Overcoming Antimicrobial Resistance: NewStrategies, Expections: Greater Hope
E. R. Sadiku (2019)
10.3389/fbioe.2020.00216
Easy One-Pot Low-Temperature Synthesized Ag-ZnO Nanoparticles and Their Activity Against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus
Atanu Naskar (2020)
10.1007/978-981-15-5274-8
Nanomaterials and Biomedicine: Therapeutic and Diagnostic Approach
E. R. Banerjee (2020)
10.2486/indhealth.2018-0197
Nanomaterials as a new opportunity for protecting workers from biological risk
A. Mansi (2019)
10.3390/pharmaceutics12020142
Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations
Nermin E Eleraky (2020)
10.3390/ijms21207748
The Response of Pseudomonas aeruginosa PAO1 to UV-activated Titanium Dioxide/Silica Nanotubes
Adrian Augustyniak (2020)
10.1007/978-3-030-34475-7_14
Engineering Approaches to Create Antibacterial Surfaces on Biomedical Implants and Devices
Runjie Tan (2020)
10.1080/0035919X.2019.1666321
Physico-chemical and antibacterial properties of gold nanoparticles synthesized using Avicennia marina seeds extract
Krishna Suresh Babu Naidu (2020)
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An overview of nanotechnology-based treatment approaches against Helicobacter Pylori
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Combining Antimicrobial Peptides with Nanotechnology: An Emerging Field in Theranostics.
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Synergy and Antagonism: The Criteria of the Formulation
Juan Bueno (2020)
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Integrating biometallurgical recovery of metals with biogenic synthesis of nanoparticles
Alok Patel (2021)
10.3390/nano10040778
A Novel Biocompatible Titanium–Gadolinium Quantum Dot as a Bacterial Detecting Agent with High Antibacterial Activity
Vishma Pratap Sur (2020)
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Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds
F. García-Villén (2019)
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Theoretical study of ciprofloxacin antibiotic trapping on graphene or boron nitride oxide nanoflakes
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Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase
Chuanjiang Dong (2019)
10.1016/j.jhazmat.2020.122319
Synthesis of biosurfactant stabilized silver nanoparticles, characterization and their potential application for bactericidal purposes.
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10.1007/978-981-15-5274-8_3
Nanomaterials and Their Use in Biomedicine
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Drug Delivery and Bone Infection.
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Phyto-Mediated Synthesis of Porous Titanium Dioxide Nanoparticles From Withania somnifera Root Extract: Broad-Spectrum Attenuation of Biofilm and Cytotoxic Properties Against HepG2 Cell Lines
N. A. Al-Shabib (2020)
10.1016/j.ecoenv.2019.109781
MoS2 decorated nanocomposite: Fe2O3@MoS2 inhibits the conjugative transfer of antibiotic resistance genes.
Honggui Wang (2019)
10.2147/DDDT.S190577
Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles
Vo Van Giau (2019)
10.1016/j.jmii.2016.04.008
Bio-Kil, a nano-based disinfectant, reduces environmental bacterial burden and multidrug-resistant organisms in intensive care units.
W. Lee (2017)
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