Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Activating Transcription Factor 3, A Useful Marker For Regenerative Response After Nerve Root Injury

H. Lindå, M. Sköld, Thomas Ochsmann
Published 2011 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Activating transcription factor 3 (ATF3) is induced in various tissues in response to stress. In this experiment, ATF3 expression was studied in adult rats subjected either to a dorsal or ventral root avulsion (VRA; L4-6), or sciatic nerve transection (SNT). Post-operative survival times varied between 1.5 h and 3 weeks. In additional experiments an avulsed ventral root was directly replanted to the spinal cord. Dorsal root ganglias (DRGs) from humans exposed to traumatic dorsal root avulsions were also examined. After SNT ATF3 immunoreactivity (ATF3 IR) was detected in a few DRG neurons already 6 h after the lesion. After 24 h the number had clearly increased and still at 3 weeks DRG neurons remained labeled. In the ventral horn, ATF3 IR in motoneurons (MN) was first detected 24 h after the SNT, and still 3 weeks post-operatively lesioned MN showed ATF3 labeling. After a VRA many spinal MN showed ATF3 IR already after 3 h, and after 6 h all MN were labeled. At 3 weeks a majority of the lesioned MN had died, but all the remaining ones were labeled. When an avulsed ventral root was directly replanted, MN survived and were still labeled at 5 weeks. In DRG, a few neurons were labeled already at 1.5 h after a dorsal root avulsion. At 24 h the number had increased but still only a minority of the neurons were labeled. At 3 days the number of labeled neurons was reduced, and a further reduction was at hand at 7 days and 3 weeks. In parallel, in humans, 3 days after a traumatic dorsal root avulsion, only a few DRG neurons showed ATF3 IR. At 6 weeks no labeled neurons could be detected. These facts imply that ATF3 response to axotomy involves a distance-dependent mechanism. ATF3 also appears to be a useful and reliable neuronal marker of nerve lesions even in humans. In addition, ATF3 up-regulation in both motor and sensory neurons seems to be linked to regenerative competence.
This paper references
10.1002/CNE.903180205
A light and electron microscopic study of intracellularly HRP‐labeled lumbar motoneurons after intramedullary axotomy in the adult cat
H. Lindå (1992)
Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury. J
K. M. Rich (1987)
10.1111/j.1460-9568.2007.05597.x
Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury
Floor J. Stam (2007)
10.1016/0306-4522(91)90356-S
c-JUN-like immunoreactivity in the CNS of the adult rat: Basal and transynaptically induced expression of an immediate-early gene
T. Herdegen (1991)
10.1007/s002210050333
Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
F. Piehl (1998)
10.1016/0304-3940(95)12078-I
Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion
L. Novikov (1995)
10.1523/JNEUROSCI.5313-06.2007
ATF3 Increases the Intrinsic Growth State of DRG Neurons to Enhance Peripheral Nerve Regeneration
Rhona Seijffers (2007)
10.3389/fneur.2010.00011
Perspectives on the Treatment of the Longitudinal Spinal Cord Injury
T. Carlstedt (2010)
10.1016/0014-4886(89)90115-5
Nerve growth factor enhances regeneration through silicone chambers
K. Rich (1989)
10.1046/j.1460-9568.2003.02809.x
Corticospinal neurons up‐regulate a range of growth‐associated genes following intracortical, but not spinal, axotomy
M. Mason (2003)
10.1523/JNEUROSCI.23-12-05187.2003
Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation
S. Nakagomi (2003)
10.1111/j.1460-9568.2005.04530.x
Spinal cord compression and dorsal root injury cause up‐regulation of activating transcription factor‐3 in large‐diameter dorsal root ganglion neurons
W. Huang (2006)
10.1016/S0140-6736(95)92342-X
Return of function after spinal cord implantation of avulsed spinal nerve roots
T. Carlstedt (1995)
Spinal cord compression and dorsal root injury cause up - regulation of activating transcription factor3 in large diameter dorsal root ganglion neurons
W. L. Huang (2006)
10.1523/JNEUROSCI.14-07-04375.1994
GAP-43 expression in primary sensory neurons following central axotomy
M. S. Chong (1994)
10.1002/(SICI)1096-9861(19981012)400:1<57::AID-CNE4>3.0.CO;2-S
Expression of insulin‐like growth factors and corresponding binding proteins (IGFBP 1–6) in rat spinal cord and peripheral nerve after axonal injuries
H. Hammarberg (1998)
10.1111/J.1748-1716.1986.TB08024.X
Reinnervation of hind limb muscles after ventral root avulsion and implantation in the lumbar spinal cord of the adult rat.
T. Carlstedt (1986)
Brain Derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat
L. Novikov (1995)
10.1016/0006-8993(85)90978-3
‘Dendraxons’ in regenerating motoneurons in the cat: do dendrites generate new axons after central axotomy?
H. Lindå (1985)
10.1016/0006-8993(91)91699-2
Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process
J. Leah (1991)
Identification of candidate
F. J. Stam (2007)
10.11501/3169170
Activating transcription factor 3 (ATF 3) induction by axotomy in sensory and motoneurons : a novel neuronal marker of nerve injury
辻野 宏明 (2000)
A spatio-temporal analysis of motoneuron survival, axonal regeneration and neurotrophic factor
R. Eggers (2010)
10.1523/JNEUROSCI.20-14-05283.2000
Neuroprotection by Encephalomyelitis: Rescue of Mechanically Injured Neurons and Neurotrophin Production by CNS-Infiltrating T and Natural Killer Cells
H. Hammarberg (2000)
10.1080/02844310701318288
Induction of activating transcription factor 3 after different sciatic nerve injuries in adult rats
K. Kataoka (2007)
10.1006/mcne.1999.0814
Activating Transcription Factor 3 (ATF3) Induction by Axotomy in Sensory and Motoneurons: A Novel Neuronal Marker of Nerve Injury
Hiroaki Tsujino (2000)
10.1089/089771503767168528
GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats.
W. Wu (2003)
ATF3, a marker for nerveinjury
10.1016/0306-4522(89)90144-9
Motoneurons reinnervate skeletal muscle after ventral root implantation into the spinal cord of the cat
S. Cullheim (1989)
10.1128/MCB.16.3.1157
Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10.
B. Chen (1996)
10.1186/1471-2202-5-9
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter
D. Hunt (2003)
10.1002/CNE.903420105
Ventral root avulsion: An experimental model of death of adult motor neurons
V. Koliatsos (1994)
10.1016/j.expneurol.2006.01.014
Astrocyte-derived transgene GDNF promotes complete and long-term survival of adult facial motoneurons following avulsion and differentially regulates the expression of transcription factors of AP-1 and ATF/CREB families
A. Parsadanian (2006)
10.1016/j.expneurol.2004.05.014
Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor
B. Blits (2004)
A light and electron microscopic study of intracellularly HRPlabeled lumbar motoneurons after intramedullary axotomy in the adult
H. Lindå (1992)
Expression of the activating transcription factor 3 prevents cJun N-terminal kinase-induced
S. Nakagomi (2003)
10.1016/j.mcn.2006.03.005
The transcription factor ATF-3 promotes neurite outgrowth
Rhona Seijffers (2006)
10.1016/j.expneurol.2009.07.021
A spatio-temporal analysis of motoneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation
R. Eggers (2010)
10.1111/j.1460-9568.2004.03241.x
NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury
S. Averill (2004)
10.1006/exnr.1996.0153
Potential Roles of Gene Expression Change in Adult Rat Spinal Motoneurons Following Axonal Injury: A Comparison among c-jun, Low-Affinity Nerve Growth Factor Receptor (LNGFR), and Nitric Oxide Synthase (NOS)
W. Wu (1996)
10.1007/BF00231661
Expression of GAP-43 mRNA in the adult mammalian spinal cord under normal conditions and after different types of lesions, with special reference to motoneurons
H. Lindå (2004)
Potential roles of gene expression change in adult rat spinal motoneurons following axonal injury: a comparison among c-jun, off-affinity nerve growth
W. Wu (1996)
c - JUNlike immunoreactivity in the CNS of the adult rat : basal and transynaptically induced expression of an immediateearly gene
T. Herdegen (1991)
10.1016/j.expneurol.2004.02.003
Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury
A. Bergerot (2004)
10.1016/S0167-4781(99)00204-3
Scanning gene expression during neuronal cell death evoked by nerve growth factor depletion.
K. Mayumi-Matsuda (1999)
10.1016/S0006-8993(96)01402-3
Timing of c-jun protein induction in lumbar dorsal root ganglia after sciatic nerve transection varies with lesion distance
A. M. Kenney (1997)
10.1016/0896-6273(90)90106-P
The regulation and function of c-fos and other immediate early genes in the nervous system
M. Sheng (1990)
Expression of GAP43 mRNA in the adult mammalian
H. Lindå (1992)
10.1186/1471-2202-9-88
Expression of ATF3 and axonal outgrowth are impaired after delayed nerve repair
H. Saito (2008)
10.1097/00001756-200004270-00021
Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion
H. Chai (2000)
10.1111/j.1460-9568.2005.04568.x
ATF3 expression in L4 dorsal root ganglion neurons after L5 spinal nerve transection
P. Shortland (2006)
ATF3 upregulation
P N. (2004)
10.1007/s00221-005-0137-4
A single re-implanted ventral root exerts neurotropic effects over multiple spinal cord segments in the adult rat
T. Hoang (2005)
10.1016/j.neulet.2008.01.012
Cell death after dorsal root injury
D. Chew (2008)
10.1111/j.1460-9568.2005.04389.x
ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis‐SOD1 transgenic mice and correlates with c‐Jun phosphorylation, CHOP expression, somato‐dendritic ubiquitination and Golgi fragmentation
A. S. Vlug (2005)
Co-tratment with riluzole and GDNF is necessary for functional recovery after ventral root
A. Bergerot (2004)
10.1016/s0021-9258(17)40754-x
ATF3 and ATF3 delta Zip. Transcriptional repression versus activation by alternatively spliced isoforms.
B. Chen (1994)
10.1007/BF01795309
Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury
K. Rich (1987)
10.1016/S0169-328X(97)00211-8
Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia.
A. M. Kenney (1997)
Expression of insulin-like growth factors and corresponding binding proteins (IGFBP 1–6) in rat
H Hammarberg (1998)
Activating transcription factor 3 (ATF3) induction by axo
H. Tsujino (2000)



This paper is referenced by
10.1002/glia.22308
Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats
T. Sanagi (2012)
Increased target reinnervation by rescued cervical motoneurons after ventral root avulsion: the effects of spinal cord – brachial plexus reconnection and riluzole treatment!
(2019)
10.1177/1744806918787427
ATF2, but not ATF3, participates in the maintenance of nerve injury-induced tactile allodynia and thermal hyperalgesia
A. Salinas-Abarca (2018)
10.1016/j.jpain.2019.06.008
Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice.
H. Starobova (2019)
10.1186/s40478-015-0255-6
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
F. Denk (2015)
10.1074/jbc.M115.696609
Acquisition of Chemoresistance and Other Malignancy-related Features of Colorectal Cancer Cells Are Incremented by Ribosome-inactivating Stress*
Chang-Kyu Oh (2016)
10.3892/mmr.2015.4442
Further insight into molecular mechanism underlying thoracic spinal cord injury using bioinformatics methods
W. Wang (2015)
10.1016/j.expneurol.2020.113390
Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury
L. Kimura (2020)
Defining Multi-Scale Relationships Between Biomechanics and Neuronal Dysfunction in Ligament Pain Using Integrated Experimental and Computational Approaches
Sijia Zhang (2017)
10.1016/j.expneurol.2016.05.029
Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats
Ana Coelho (2016)
10.1177/1744806919892389
Establishment of a mouse model for injury-induced scar formation and the accompanying chronic pain: Comprehensive microarray analysis of molecular expressions in fibrosis and hyperalgesia
Yuqiang Li (2019)
10.1371/journal.pone.0072995
Bortezomib-Induced Painful Peripheral Neuropathy: An Electrophysiological, Behavioral, Morphological and Mechanistic Study in the Mouse
V. Carozzi (2013)
10.1016/j.virusres.2020.197986
An in silico integrative protocol for identifying key genes and pathways useful to understand emerging virus disease pathogenesis.
Gabriel Augusto Pires de Souza (2020)
The majority of TLRs recruit the MyD88-IRAK-TRAF6 pathway, culminating in the activation of nuclear factor-κB, which drives the transcription of genes encoding pro-inflam-
Dongxue Ding (2014)
10.3389/fneur.2017.00049
Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury
Tomas Lindholm (2017)
10.1016/j.forsciint.2019.109937
ATF3 mRNA, but not BTG2, as a possible marker for vital reaction of skin contusion.
Dong Qu (2019)
10.1016/j.jsxm.2018.11.010
Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth.
S. Powers (2019)
10.1097/PR9.0000000000000846
Pain-related behavior is associated with increased joint innervation, ipsilateral dorsal horn gliosis, and dorsal root ganglia activating transcription factor 3 expression in a rat ankle joint model of osteoarthritis
Valerie Bourassa (2020)
10.1158/0008-5472.CAN-18-3872
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth.
G. Shurin (2019)
10.1016/j.stemcr.2015.11.004
Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson’s Disease-Related LRRK2 G2019S Mutation
A. Schwab (2015)
10.1007/s12031-015-0588-4
Identification of the Avulsion-Injured Spinal Motoneurons
M. Tan (2015)
10.1016/j.ajpath.2020.03.004
Atrophy and death of non-peptidergic and peptidergic nociceptive neurons in SIV infection.
Jake A. Robinson (2020)
10.4103/1673-5374.217319
Beta secretase activity in peripheral nerve regeneration
C. Tallon (2017)
10.1007/s12031-013-0095-4
Structural and Molecular Alterations of Primary Afferent Fibres in the Spinal Dorsal Horn in Vincristine-Induced Neuropathy in Rat
K. Thibault (2013)
10.1002/jnr.23262
Quantitative profiling and identification of differentially expressed plasma proteins in friedreich's ataxia
V. Swarup (2013)
10.1111/ejn.13089
Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion
R. Eggers (2016)
10.3892/mmr.2014.2256
Dynamic expression patterns of ATF3 and p53 in the hippocampus of a pentylenetetrazole-induced kindling model
D. Ding (2014)
Micromotion And Scarring Do Not Contribute To Failure Of Regenerative Peripheral Neural Interfacing
N. Khobragade (2014)
10.3892/etm.2016.3130
Selected gene profiles of stressed NSC-34 cells and rat spinal cord following peripheral nerve reconstruction and minocycline treatment
G. Keilhoff (2016)
10.1186/s12974-019-1496-2
Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice
S. M. Borghi (2019)
10.1002/ejp.650
Morphological and functional changes in regenerated primary afferent fibres following mental and inferior alveolar nerve transection
Y. Tsuboi (2015)
10.1213/ANE.0000000000000161
The Effects of Glucocorticoids on Neuropathic Pain: A Review with Emphasis on Intrathecal Methylprednisolone Acetate Delivery
M. Rijsdijk (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar