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Simply Adding Oxygen During Hypothermic Machine Perfusion To Combat The Negative Effects Of Ischemia-Reperfusion Injury: Fundamentals And Current Evidence For Kidneys

Tom Darius, Jay Nath, Michel Mourad

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The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes as well as to decrease organ discard rate. With oxygenation proposed as a resuscitative measure during hypothermic machine preservation, this review provides a critical overview of the fundamentals of active oxygenation during hypothermic machine perfusion, as well as the current preclinical and clinical evidence and suggests different strategies for clinical implementation.