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The Cytolethal Distending Toxin Effects On Mammalian Cells: A DNA Damage Perspective

Elisabeth Bezine, J. Vignard, G. Mirey
Published 2014 · Biology, Medicine

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The cytolethal distending toxin (CDT) is produced by many pathogenic Gram-negative bacteria and is considered as a virulence factor. In human cells, CDT exposure leads to a unique cytotoxicity associated with a characteristic cell distension and induces a cell cycle arrest dependent on the DNA damage response (DDR) triggered by DNA double-strand breaks (DSBs). CDT has thus been classified as a cyclomodulin and a genotoxin. Whereas unrepaired damage can lead to cell death, effective, but improper repair may be detrimental. Indeed, improper repair of DNA damage may allow cells to resume the cell cycle and induce genetic instability, a hallmark in cancer. In vivo, CDT has been shown to induce the development of dysplastic nodules and to lead to genetic instability, defining CDT as a potential carcinogen. It is therefore important to characterize the outcome of the CDT-induced DNA damage and the consequences for intoxicated cells and organisms. Here, we review the latest results regarding the host cell response to CDT intoxication and focus on DNA damage characteristics, cell cycle modulation and cell outcomes.
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10.1159/000494052
Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer
Caizhao Lin (2018)
10.5812/IJCP.5792
Sensitization of Radio-Resistant Lung Cancer Cells with a B Subunit of Bacterial Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans
Hajar Yaghoobi (2017)
10.1128/JCM.02070-19
Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017
Cooper J. Park (2020)
10.3390/cells9040829
Vγ9Vδ2 T Cells: Can We Re-Purpose a Potent Anti-Infection Mechanism for Cancer Therapy?
K. Kuenkele (2020)
Rôle de l'autophagie dans la réponse de l'hôte suite à l'infection par des Escherichia Coli producteurs de colibactine isolés de patients atteints d'un cancer colorectal
C. Lucas (2018)
10.3389/fcimb.2017.00208
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections
Rachid A. El-Aouar Filho (2017)
Biotechnological and clinical potential of AIP56 toxin
Inês S Rodrigues (2014)
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