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Clinical Advances In Molecular Biomarkers For Cancer Diagnosis And Therapy

S. Sethi, S. Ali, P. Philip, F. Sarkar
Published 2013 · Biology, Medicine

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Cancer diagnosis is currently undergoing a paradigm shift with the incorporation of molecular biomarkers as part of routine diagnostic panel. The molecular alteration ranges from those involving the DNA, RNA, microRNAs (miRNAs) and proteins. The miRNAs are recently discovered small non-coding endogenous single-stranded RNAs that critically regulates the development, invasion and metastasis of cancers. They are altered in cancers and have the potential to serve as diagnostic markers for cancer. Moreover, deregulating their activity offers novel cancer therapeutic approaches. The availability of high throughput techniques for the identification of altered cellular molecules allowed their use in cancer diagnosis. Their application to a variety of body specimens from blood to tissues has been helpful for appreciating their use in the clinical context. The development of innovative antibodies for immunohistochemical detection of proteins also assists in diagnosis and risk stratification. Overall, the novel cancer diagnostic tools have extended their application as prognostic risk factors and can be used as targets for personalized medicine.
This paper references
Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic Trials
Christine M. Lovly (2012)
Multiplex genotyping of CYP3A4, CYP3A5, CYP2C9 and CYP2C19 SNPs using MALDI-TOF mass spectrometry.
M. Falzoi (2010)
Are Results of Targeted Gene Sequencing Ready to Be Used for Clinical Decision Making for Patients with Acute Myelogenous Leukemia?
A. Rao (2013)
Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells.
A. Ahmad (2011)
Progressing the utilisation of pharmacogenetics and pharmacogenomics into clinical care.
R. Trent (2013)
KRAS Mutation in Stage III Colon Cancer and Clinical Outcome Following Intergroup Trial CALGB 89803
S. Ogino (2009)
Companion diagnostic testing for targeted cancer therapies: an overview.
Yao-Shan Fan (2013)
Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: A French multicenter prospective study on behalf of the FRALLE
R Garand (2013)
Whole miRNome-wide Differential Co-expression of MicroRNAs
C. F. Stähler (2012)
Molecular oncodiagnostics: where we are and where we need to go.
E. Liu (2003)
Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.
S. Ali (2010)
Epigenetics and colorectal cancer
V. Lao (2011)
Potential epigenetic biomarkers for the diagnosis and prognosis of pancreatic ductal adenocarcinomas
J. Hinton (2013)
MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer
S. Ali (2012)
Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells
D. Kong (2010)
Aspirin as adjuvant therapy for colorectal cancer—reinterpreting paradigms
W. K. Chia (2012)
miRvestigator: web application to identify miRNAs responsible for co-regulated gene expression patterns discovered through transcriptome profiling
C. Plaisier (2011)
microRNA detection in feces, sputum, pleural effusion and urine: novel tools for cancer screening (Review).
Yufeng Xiao (2013)
Alterations in Gene Expression of Proprotein Convertases in Human Lung Cancer Have a Limited Number of Scenarios
I. Demidyuk (2013)
Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications
N. Kitkumthorn (2011)
Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer.
S. Sethi (2013)
Evolving Concept of Cancer Stem Cells: Role of Micro-RNAs and their Implications in Tumor Aggressiveness
S. Sethi (2011)
Aspirin as Adjuvant Therapy for Colorectal Cancer
A. Neugut (2009)
Rapid microRNA detection using power-free microfluidic chip: coaxial stacking effect enhances the sandwich hybridization.
Hideyuki Arata (2012)
Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL
R. Garand (2013)
Molecular typing of epithelial ovarian carcinomas using inflammatory markers
R. Ali-Fehmi (2011)
Mutation Profiling and Microsatellite Instability in Stage II and III Colon Cancer: An Assessment of Their Prognostic and Oxaliplatin Predictive Value
P. G. Gavin (2012)
Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers
Y. Imamura (2012)
let-7b and miR-126 Are Down-Regulated in Tumor Tissue and Correlate with Microvessel Density and Survival Outcomes in Non–Small–Cell Lung Cancer
E. Jusufović (2012)
Design and analytic validation of BCR-ABL1 quantitative reverse transcription polymerase chain reaction assay for monitoring minimal residual disease.
L. Jennings (2012)
NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
P. Febbo (2011)
Mutations in Specific Codons of the KRAS Oncogene are Associated with Variable Resistance to Neoadjuvant Chemoradiation Therapy in Patients with Rectal Adenocarcinoma
Marjun P. Duldulao (2013)
Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP–CGH analysis
A. Hosein (2013)
Recent updates on the role of microRNAs in prostate cancer
O. Hassan (2012)
Vemurafenib in patients with BRAF V600E mutation-positive advanced melanoma.
Marcus C. Ravnan (2012)
Characterization of Russian universal kits for real-time PCR: Application to molecular oncodiagnosis
O. Y. Manzeniuk (2006)
Additional prognostic value of the 70-gene signature (MammaPrint(®)) among breast cancer patients with 4-9 positive lymph nodes.
M. Saghatchian (2013)
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells
S. Ali (2012)
Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science.
S. Ogino (2012)
Cancer immunologyof host and tumor factors for personalized medicine
S. Ogino (2011)
MiRNA‐199a‐3p: A potential circulating diagnostic biomarker for early gastric cancer
Chen Li (2013)
Molecular Pathways: Extracting Medical Knowledge from High-Throughput Genomic Data
T. Goldstein (2013)
Characterization of microRNA expression profiles in normal human tissues
Yu Liang (2007)
Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells
A. Ahmad (2012)
Molecular markers of epithelial-to-mesenchymal transition are associated with tumor aggressiveness in breast carcinoma.
S. Sethi (2011)
Network modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism.
A. Azmi (2011)
Comparison of EndoPredict and Oncotype DX Test Results in Hormone Receptor Positive Invasive Breast Cancer
Z. Varga (2013)
Risk-based classification of leukemia by cytogenetic and multiplex molecular methods: results from a multicenter validation study
C. Gocke (2012)
Potential biomarker for aspirin use in colorectal cancer therapy: Biological markers
R. Langley (2013)
Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I
A. Mian (2012)
Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data.
C. Guastadisegni (2010)
Biological markers: Potential biomarker for aspirin use in colorectal cancer therapy
R. E. Langley (2013)
Rapid Detection of Prognostically Significant Fusion Transcripts in Acute Leukemia Using Simplified Multiplex Reverse Transcription Polymerase Chain Reaction
Y. Cho (2012)
MicroRNA expression profiles classify human cancers
J. Lu (2005)
Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM
D. Kong (2012)
RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina.
C. Alonso (2012)
Use of Luminex xMAP bead-based suspension array for detecting microRNA in NSCLC tissues and its clinical application.
Y. Wang (2012)
Does addition of BRAF V600E mutation testing modify sensitivity or specificity of the Afirma Gene Expression Classifier in cytologically indeterminate thyroid nodules?
R. T. Kloos (2013)
Targeted therapy and immunotherapy in advanced melanoma: an evolving paradigm
M. Khattak (2013)
Blood-based miRNAs as noninvasive diagnostic and surrogative biomarkers in colorectal cancer
T. Gall (2013)
Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer
B. Bao (2011)
One-step real time RT-PCR for detection of microRNAs.
Jingli Yan (2013)
miR-146a suppresses invasion of pancreatic cancer cells.
Y. Li (2010)
Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment.
K. Bouchalová (2010)
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.
X. Liao (2012)
Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K‐Ras transgenic mouse model of pancreatic cancer
S. Ali (2012)
Circulating miR-155 Expression in Plasma: A Potential Biomarker for Early Diagnosis of Esophageal Cancer in Humans
Ran Liu (2012)
[Characterization of the universal Russian reagent sets for real-time PCR and its application for molecular oncodiagnostic].
O. I. Manzeniuk (2006)
Clinical relevance of cancer genome sequencing.
C. S. Ku (2013)
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.
Pedro Castelo-Branco (2013)
Pulmonary Langerhans cell histiocytosis: profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations.
S. Yousem (2013)
Cancer immunology—analysis of host and tumor factors for personalized medicine
S. Ogino (2011)
A Mathematical Model for MicroRNA in Lung Cancer
Hye-Won Kang (2013)
Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer.
S. Ali (2010)
Improved survival with vemurafenib in melanoma with BRAF V600E mutation.
P. Chapman (2011)
Characteristics and survival of head and neck cancer by HPV status: a cancer registry‐based study
S. Sethi (2012)
EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity.
E. Galvani (2012)
A novel electrically magnetic-controllable electrochemical biosensor for the ultra sensitive and specific detection of attomolar level oral cancer-related microRNA.
Zongwen Wang (2013)

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Automatic detection of protein degradation markers in mass spectrometry imaging
S. Herman (2016)
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Juliana I. Santos (2013)
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.
K. Vougas (2019)
Prediction of clinical outcomes in mantle cell lymphoma using the ACB 2000 pyrolysis 1 system
A. Inamdar (2015)
Progress in cancer biomarkers monitoring strategies using graphene modified support materials.
S. Zaidi (2020)
Cancer Immunotherapy and Personalized Medicine: Emerging Technologies and Biomarker-Based Approaches
L. Maciejko (2017)
Common and Unique microRNAs in Multiple Carcinomas Regulate Similar Network of Pathways to Mediate Cancer Progression
Divya Niveditha (2020)
Long noncoding RNAs biomarker‐based cancer assessment
Mohammad Sarfi (2019)
miRNA: An Overview of its Role in Cancer Research and Diagnosis
Girish K. Goswami (2017)
Drug Resistance Biomarkers and Their Clinical Applications in Childhood Acute Lymphoblastic Leukemia
N. Aberuyi (2019)
Innovative Diagnostic Methods for Early Prostate Cancer Detection through Urine Analysis: A Review
Carmen Bax (2018)
Drugs acting on homeostasis: challenging cancer cell adaptation
M. Moschovi (2015)
The Prognostic and Clinicopathologic Characteristics of OCT4 and Lung Cancer: A Meta-Analysis.
H. Li (2019)
High-throughput analysis and functional interpretation of extracellular vesicle content in hematological malignancies
Ilaria Tanasi (2020)
Prediction of clinical outcomes using the pyrolysis, gas chromatography, and differential mobility spectrometry (Py-GC-DMS) system
A. Inamdar (2016)
Comprehensive analysis of prognosis‐related methylated sites in breast carcinoma
J. Li (2020)
Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71
R. Parenti (2014)
miR-224/miR-141 ratio as a novel diagnostic biomarker in renal cell carcinoma
X. Chen (2018)
Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion.
X. Li (2017)
Exploring Potential of RPPA Technique in Oral Cancer Biomarker Discovery Research
N. Singh (2019)
Expression of stemness genes in primary breast cancer tissues: the role of SOX2 as a prognostic marker for detection of early recurrence
Mauro Finicelli (2014)
MicroRNA-143 Targets Syndecan-1 to Repress Cell Growth in Melanoma
R. Li (2014)
Effects of Flow‐Induced Microfluidic Chip Wall Deformation on Imaging Flow Cytometry
Y. Yalikun (2019)
Recent trends in electrochemical microRNA biosensors for early detection of cancer
Mahin Keshavarz (2015)
Malignant pleural mesothelioma: current and future perspectives.
Konstantinos Porpodis (2013)
Cytokine genes as potential biomarkers for muscle weakness in OPMD.
Muhammad Riaz (2016)
Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production
V. Leoncikas (2016)
Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions
M. Dowling (2019)
1-butyltryptophan inhibits cell proliferation, migration, and invasion through the Akt pathway in human gastric cancer cells
T. Sun (2014)
The application of monoclonal antibodies in cancer diagnosis
X. Zhang (2014)
Análisis de la expresión de marcadores tumorales en muestras de tumores humanos
Ismael Moreno Sánchez (2014)
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