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The Role Of Reactive Oxygen Species (ROS) In The Biological Activities Of Metallic Nanoparticles

Ahmed Abdal Dayem, Mohammed Kawser Hossain, Soo bin Lee, Kyeongseok Kim, Subbroto Kumar Saha, Gwang-Mo Yang, Hye yeon Choi, Ssang-Goo Cho
Published 2017 · Biology, Medicine
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Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices.
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10.15436/2471-5891.19.2496
Antioxidant Effects of the Biofield Energy Treated Novel Proprietary Test Formulation in Male Wistar Rats
Mahendra Kumar Trivedi (2019)
10.1007/s12034-020-2064-1
Silver nanoparticles biosynthesized by Anabaena flos-aquae enhance the apoptosis in breast cancer cell line
Z Ebrahimzadeh (2020)
10.1007/s00216-018-1233-1
Emerging technologies for optical spectral detection of reactive oxygen species
Johanna Herman (2018)
10.1007/s00253-017-8611-z
Amine-modified magnetic iron oxide nanoparticle as a promising carrier for application in bio self-healing concrete
Mostafa Seifan (2017)
10.5772/INTECHOPEN.76567
Tools for Assessment of Occupational Health Risks of some Engineered Nanoparticles and Carbon Materials Used in Semiconductor Applications
Ponnapat Watjanatepin (2018)
10.1007/S12668-018-0552-1
Oligodynamic Effect of Silver Nanoparticles: a Review
Parteek Prasher (2018)
10.2131/jts.45.117
Silica nanoparticles enhance germ cell apoptosis by inducing reactive oxygen species (ROS) formation in Caenorhabditis elegans.
Fangfang Zhang (2020)
10.1080/09205063.2019.1580664
Functionalized photosensitive gelatin nanoparticles for drug delivery application
Janicy Arantes Carvalho (2019)
10.1039/c9nr10421f
Synergistic interactions of cadmium-free quantum dots embedded in a photosensitised polymer surface: efficient killing of multidrug-resistant strains at low ambient light levels.
Ethel G A Owusu (2020)
10.1007/978-3-030-33962-3_8
Oxidative Stress and Redox Modifications in Nanomaterial–Cellular Interactions
Tong Zhang (2020)
10.1016/j.mimet.2019.105736
Synthesis and characterization of nanoparticles and composites as bactericides.
Laleh Ranandeh Kalankesh (2019)
The interaction of nanoparticles with mucosal barriers
Muneef Manea A Aldhafeeri (2019)
10.3390/ijms21082864
The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos
Ziyu Chen (2020)
10.15406/mojap.2019.06.00261
Alteration in the activities of antioxidant enzymes and lipid peroxidation in mice transplanted with Dalton’s lymphoma ascites tumor by Helicia Nilagirica Bedd
Ganesh Chandra Jagetia (2019)
10.1016/j.carbpol.2020.116175
Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies.
M. El-aassar (2020)
10.3389/fbioe.2020.00822
The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective
Shokouh Attarilar (2020)
10.3389/fbioe.2019.00447
Nanodelivery of Natural Antioxidants: An Anti-aging Perspective
Alexander M Vaiserman (2019)
10.3390/ma13010017
Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy
Jaspreet Singh Nagi (2019)
10.1016/j.envres.2019.108945
Understanding effect of interaction of nanoparticles and antibiotics on bacteria survival under aquatic conditions: Knowns and unknowns.
Neha Tyagi (2019)
10.1016/J.SCITOTENV.2019.06.010
Evaluation of the toxicity of 1-butyl-3-methyl imidazolium tetrafluoroborate using earthworms (Eisenia fetida) in two soils.
Yuting Shao (2019)
10.1016/J.IMPACT.2019.100165
Comparing the sensitivity of different intestinal Caco-2 in vitro monocultures and co-cultures to amorphous silicon dioxide nanomaterials and the clay montmorillonite
Victor Chibueze Ude (2019)
10.1007/978-3-030-05144-0_2
Nano-bio Interactions and Ecotoxicity in Aquatic Environment: Plenty of Room at the Bottom but Tyranny at the Top!
Jayanta Kumar Biswas (2018)
10.1016/j.biopha.2019.109043
L-Lysine protects against sepsis-induced chronic lung injury in male albino rats.
Chunyun Zhang (2019)
10.1002/cmdc.202000119
In vitro biological tests as the first tools to validate magnetic nanotheranostics for colorectal cancer models.
María Julia Martín (2020)
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