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Peritoneal Mesothelioma With Residential Asbestos Exposure. Report Of A Case With Long Survival (Seventeen Years) Analyzed By Cgh-Array
G. Serio, F. Pezzuto, A. Marzullo, A. Scattone, D. Cavone, A. Punzi, Francesco Fortarezza, M. Gentile, A. L. Buonadonna, M. Barbareschi, L. Vimercati
Published 2017 · Medicine
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Malignant mesothelioma is a rare and aggressive tumor with limited therapeutic options. We report a case of a malignant peritoneal mesothelioma (MPM) epithelioid type, with environmental asbestos exposure, in a 36-year-old man, with a long survival (17 years). The patient received standard treatment which included cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods and Results: Molecular analysis with comparative genomic hybridization (CGH)-array was performed on paraffin-embedded tumoral samples. Multiple chromosomal imbalances were detected. The gains were prevalent. Losses at 1q21, 2q11.1→q13, 8p23.1, 9p12→p11, 9q21.33→q33.1, 9q12→q21.33, and 17p12→p11.2 are observed. Chromosome band 3p21 (BAP1), 9p21 (CDKN2A) and 22q12 (NF2) are not affected. Conclusions: the defects observed in this case are uncommon in malignant peritoneal mesothelioma. Some chromosomal aberrations that appear to be random here, might actually be relevant events explaining the response to therapy, the long survival and, finally, may be considered useful prognostic factors in peritoneal malignant mesothelioma (PMM).
This paper references
Genome-wide analysis of abdominal and pleural malignant mesothelioma with DNA arrays reveals both common and distinct regions of copy number alteration
A. Borczuk (2016)
Gene copy number analysis in malignant pleural mesothelioma using oligonucleotide array CGH
P. M. Lindholm (2007)
WHO classification of tumours of the lung, pleura, thymus and heart
W. Travis (2015)
PinX1: structure, regulation and its functions in cancer
H. Li (2016)
Molecular changes in mesothelioma with an impact on prognosis and treatment.
D. Jean (2012)
Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells.
Joo-Hee An (2011)
A Histomorphologic Grading System That Predicts Overall Survival in Diffuse Malignant Peritoneal Mesothelioma With Epithelioid Subtype
Kari Valente (2016)
Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.
Anna-Maria Stock (2015)
Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology
M. Kanarek (2016)
Mesothelioma risk after 40 years since first exposure to asbestos: a pooled analysis
A. Reid (2014)
Characterization of a complex chromosome aberration in two cases of peritoneal mesothelioma arising primarily in the hernial sac
Gabriella Serio (2009)
A Comprehensive Genome-Based Mutational Analysis by Next Generation Sequencing Technology in Patients With Malignant Pleural and Peritoneal Mesothelioma
G. Ugurluer (2015)
Tumor suppressor p53 and its gain-of-function mutants in cancer.
J. Liu (2014)
Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells
Y. Cao (2008)
Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey.
A. Dogan (2006)
Genomic Profiling of Malignant Peritoneal Mesothelioma Reveals Recurrent Alterations in Epigenetic Regulatory Genes BAP1, SETD2, and DDX3X
N. Joseph (2017)
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
R. Bueno (2016)
Distinctive clinical characteristics of malignant mesothelioma in young patients
A. Thomas (2015)
Genomic copy number alterations in 33 malignant peritoneal mesothelioma analyzed by comparative genomic hybridization array.
P. Chirac (2016)
Combination raltitrexed (Tomudex(R))-oxaliplatin: a step forward in the struggle against mesothelioma? The Institut Gustave Roussy experience with chemotherapy and chemo-immunotherapy in mesothelioma.
K. Fizazi (2000)
Comparison of genomic abnormality in malignant mesothelioma by the site of origin
M. Takeda (2014)
Comparative genomic hybridization study on pooled DNAs from tumors of one clinical-pathological entity.
S. Knuutila (1998)
BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma
H. Alakus (2015)
Genomic profiling of malignant pleural mesothelioma with array‐based comparative genomic hybridization shows frequent non‐random chromosomal alteration regions including JUN amplification on 1p32
T. Taniguchi (2007)
Genomic Landscape of Malignant Mesotheliomas.
S. Kato (2016)
Personalized Oncogenomics: Clinical Experience with Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing
B. Sheffield (2015)
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
F. Baumann (2015)
Familial pleural mesothelioma with environmental asbestos exposure: losses of DNA sequences by comparative genomic hybridization (CGH)
G. Serio (2004)
The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma
A. Singhi (2016)
Genome-based Mutational Analysis by Next Generation Sequencing in Patients with Malignant Pleural and Peritoneal Mesothelioma.
G. Ugurluer (2016)
A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma.
T. Yan (2007)
Prognostic significance of morphological growth patterns and mitotic index of epithelioid malignant peritoneal mesothelioma
A. Krasinskas (2016)
The prognostic significance of BAP 1 , NF 2 , and CDKN 2 A in malignant peritoneal mesothelioma PinX 1 : Structure , regulation and its functions in cancer
BAP 1 mutation is a frequent somatic event in peritoneal malignant mesothelioma Different prognostic roles of tumor suppressor gene BAP 1 in cancer : A systematic review with meta - analysis
PinX1, a novel target gene of p53, is suppressed by HPV16 E6 in cervical cancer cells.
Gengze Wu (2014)
Different prognostic roles of tumor suppressor gene BAP1 in cancer: A systematic review with meta‐analysis
C. Luchini (2016)
Cytogenetic and molecular genetic changes in malignant mesothelioma.
M. Musti (2006)
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Sophie Sneddon (2018)
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Mesotheliomas in Genetically Engineered Mice Unravel Mechanism of Mesothelial Carcinogenesis
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A Single Liver Metastasis from Pleural Biphasic Mesothelioma
A. Marzullo (2020)
Malignant mesothelioma in construction workers: the Apulia regional mesothelioma register, Southern Italy
L. Vimercati (2019)
Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia (southern Italy) mesothelioma register
L. Vimercati (2019)
Health impact of exposure to asbestos in polluted area of Southern Italy
L. Vimercati (2019)
Non-Melanoma Skin Cancer in Outdoor Workers: A Study on Actinic Keratosis in Italian Navy Personnel
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Genomic changes of chromosomes 8p23.1 and 1q21: Novel mutations in malignant mesothelioma.
Gabriella Serio (2018)