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Emerging Nanomedicine Therapies To Counter The Rise Of Methicillin-Resistant Staphylococcus Aureus
Alan J Hibbitts, Cian O'Leary
Published 2018 · Medicine
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In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this threat, with persistent and resilient strains detectable in up to 90% of S. aureus infections. Unfortunately, there is a lack of novel antibiotics reaching the clinic to address the significant morbidity and mortality that MRSA is responsible for. Recently, nanomedicine strategies have emerged as a promising therapy to combat the rise of MRSA. However, these approaches have been wide-ranging in design, with few attempts to compare studies across scientific and clinical disciplines. This review seeks to reconcile this discrepancy in the literature, with specific focus on the mechanisms of MRSA infection and how they can be exploited by bioactive molecules that are delivered by nanomedicines, in addition to utilisation of the nanomaterials themselves as antibacterial agents. Finally, we discuss targeting MRSA biofilms using nano-patterning technologies and comment on future opportunities and challenges for MRSA treatment using nanomedicine.
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Novel approaches for the treatment of methicillin-resistant Staphylococcus aureus: using nanoparticles to overcome multidrug resistance.
Kushal Vanamala (2020)
Nanoparticles for treatment of bovine Staphylococcus aureus mastitis
S. Algharib (2020)
Electrospun Vancomycin-loaded Nanofibers for Management of Methicillin-resistant Staphylococcus aureus-induced Skin Infections.
Heba A Fathi (2020)
Lipid-based nanosystems for targeting bone implant-associated infections: current approaches and future endeavors
Magda Ferreira (2020)
Monitoring of multiresistant community-associated MRSA strains from patients with pathological processes of different localization
T. V. Sklyar (2018)
The Fabrication and in vitro Evaluation of Retinoic Acid-Loaded Electrospun Composite Biomaterials for Tracheal Tissue Regeneration
Cian O'Leary (2020)
Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against Staphylococcus aureus
Stephanie Fulaz (2020)
Preclinical Evaluation of Antimicrobial Nanodrugs
J. Bueno (2020)
The Continuing Threat of Methicillin-Resistant Staphylococcus aureus
M. Gajdács (2019)
Multi-functionalized nanocarriers targeting bacterial reservoirs to overcome challenges of multi drug-resistance
Maria Hassan Kiani (2020)