Marine Seaweed Polysaccharides-Based Engineered Cues For The Modern Biomedical Sector
Muhammad Bilal, Hafiz M. N. Iqbal
Published 2019 · Biology, Medicine
Download PDFAnalyze on Scholarcy
Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.
This paper references
Alginate based polyurethanes: A review of recent advances and perspective.
Khalid Mahmood Zia (2015)
Effects of solar radiation on the skin.
Thomas G. Polefka (2012)
Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro
Marcel T Ale (2011)
Intrinsic and extrinsic factors in skin ageing: a review.
Miranda A Farage (2008)
Structural characterization and anticancer activity (MCF7 and MDA-MB-231) of polysaccharides fractionated from brown seaweed Sargassum wightii.
Ramalingam Vaikundamoorthy (2018)
Enzyme-assisted extraction of Nizamuddinia zanardinii for the recovery of sulfated polysaccharides with anticancer and immune-enhancing activities
Mehdi Alboofetileh (2018)
Extraction of alginate from brown seaweeds and evolution of bioactive alginate film coated textile fabrics for wound healing application
M Janarthanan (2019)
Interpenetrating alginate on gelatin–poly(2-hydroxyethyl methacrylate) as a functional polymeric matrix for cartilage tissue engineering
Deepti Singh (2019)
Effects of Fucoidan and Chemotherapeutic Agent Combinations on Malignant and Non-malignant Breast Cell Lines.
Aisha Abudabbus (2017)
A perspective on magnetic core–shell carriers for responsive and targeted drug delivery systems
Kholoud E Albinali (2019)
Chitosan-alginate hybrid scaffolds for bone tissue engineering.
Zhensheng Li (2005)
Biomimetic nanostructures/cues as drug delivery systems: a review
Tahir Rasheed (2019)
High-value compounds from microalgae with industrial exploitability - A review.
Muhammad Bilal (2017)
Alginate composites for bone tissue engineering: a review.
Jayachandran Venkatesan (2015)
Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels
Jake Barralet (2005)
Ecofriendly one pot fabrication of methyl gallate@ZIF-L nanoscale hybrid as pH responsive drug delivery system for lung cancer therapy
Raju Prabhu (2019)
Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells.
Ponnan Arumugam (2019)
Marine organisms as a source of natural matrix for bone tissue engineering
V. Lalzawmliana (2019)
Endogenous and Exogenous Stimuli-Responsive Drug Delivery Systems for Programmed Site-Specific Release
Ali Raza (2019)
Antioxidant, antibacterial and in vivo wound healing properties of laminaran purified from Cystoseira barbata seaweed.
Sabrine Sellimi (2018)
Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications
Ludmylla Cunha (2016)
Structural properties and protective effect of Sargassum fusiforme polysaccharides against ultraviolet B radiation in hairless Kun Ming mice
Yuhui Ye (2018)
The differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice.
Seungbeom Park (2010)
Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications.
Elena Geta Popa (2015)
Extraction, structure and biofunctional activities of laminarin from brown algae
Shekhar U. Kadam (2015)
Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites.
Dong-Joon Park (2005)
TNFR1/TNF-α and mitochondria interrelated signaling pathway mediates quinocetone-induced apoptosis in HepG2 cells.
Chaoming Zhang (2013)
Sulfated fucans, fresh perspectives: structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide.
Olivier Berteau (2003)
Alginate/Hydroxyapatite biocomposite for bone ingrowth: a trabecular structure with high and isotropic connectivity.
Gianluca Turco (2009)
Photosensitizing activity of advanced glycation endproducts on tryptophan, glucose 6-phosphate dehydrogenase, human serum albumin and ascorbic acid evaluated at low oxygen pressure.
Denis Fuentealba (2007)
Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae
Janet Helen Fitton (2015)
Production and characterisation of alginate from Azotobacter vinelandii
Francesca Clementi (1999)
Improvement of antioxidant and moisture-preserving activities of Sargassum horneri polysaccharide enzymatic hydrolyzates.
Ping Shao (2015)
State-of-the-Art Extraction Methodologies for Bioactive Compounds from Algal Biome to Meet Bio-Economy Challenges and Opportunities
Juan Eduardo Sosa-Hernández (2018)
Photoaging: New insights into its stimulators, complications, biochemical changes and therapeutic interventions
Harshit S. Shah (2013)
Effect of Costaria costata fucoidan on expression of matrix metalloproteinase-1 promoter, mRNA, and protein.
Hee Jung Moon (2009)
Effects of Ultrasound Treatment on the Chemical Composition and Anticoagulant Properties of Dry Fucus Extract
E. D. Obluchinsksya (2015)
Fucoidan modulates the effect of transforming growth factor (TGF)-beta1 on fibroblast proliferation and wound repopulation in in vitro models of dermal wound repair.
Ronan O’Leary (2004)
An anticoagulative polysaccharide from an enzymatic hydrolysate of Ecklonia cava
Yasantha Athukorala (2005)
Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering.
Gil-Su Lee (2011)
Beneficial effects of fucoidan on osteoblastic MG-63 cell differentiation
Young-Sook Cho (2009)
Biological activity of algal sulfated and nonsulfated polysaccharides.
Pilar Rupérez (2013)
Injectable in situ dual-crosslinking hyaluronic acid and sodium alginate based hydrogels for drug release
Yufan Zhang (2019)
Partial Characterization, the Immune Modulation and Anticancer Activities of Sulfated Polysaccharides from Filamentous Microalgae Tribonema sp.
Xiaolin Chen (2019)
Neural tissue engineering: strategies for repair and regeneration.
Christine E Schmidt (2003)
Algal polysaccharides: potential bioactive substances for cosmeceutical applications
Ilekuttige Priyan Shanura Fernando (2018)
Toxic effects of ultraviolet radiation on the skin.
Yasuhiro Matsumura (2004)
Design and Processing Aspects of Polymer and Composite Materials
Hafiz M.N. Iqbal (2018)
Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering
Jayachandran Venkatesan (2014)
Role of seaweed laminaran from Saccharina longicruris on matrix deposition during dermal tissue-engineered production.
Akram Ayoub (2015)
Drug delivery systems: An updated review
Gaurav Tiwari (2012)
Metabolites from algae with economical impact.
Karina Helena Morais Cardozo (2007)
Alginate: properties and biomedical applications.
Kuen Yong Lee (2012)
Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
Mohammad R Irhimeh (2007)
Fabrication and characterization of hydroxyapatite/sodium alginate/chitosan composite microspheres for drug delivery and bone tissue engineering.
Yong-guang Bi (2019)
The Potential Application of Spring Sargassum glaucescens Extracts in the Moisture-Retention of Keratinocytes and Dermal Fibroblast Regeneration after UVA-Irradiation
Zih-yi Li (2019)
Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts.
Hee Jung Moon (2009)
Repair Effect of Seaweed Polysaccharides with Different Contents of Sulfate Group and Molecular Weights on Damaged HK-2 Cells
Poonam Bhadja (2016)
Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract
Jangbeen Kyung (2012)
Polysaccharides and their derivatives for versatile tissue engineering application.
Ferdous Hossain Khan (2013)
Carrageenans: biological properties, chemical modifications and structural analysis - a review.
Vanessa Leiria Campo (2009)
Structure and functional properties of ulvan, a polysaccharide from green seaweeds.
Marc Lahaye (2007)
Characterization of polysaccharides extracted from brown seaweeds
Laurie-Eve Rioux (2007)
Falkenbergia rufolanosa polysaccharide - poly (vinyl alcohol) composite films: A promising wound healing agent against dermal laser burnsin rats.
Amal Feki (2019)
Novel synthesis of l-iduronic acid using trehalose as the disaccharidic starting material
Hiroshi Hinou (1999)
Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats
Olga N Pozharitskaya (2018)
Potential effects of a low-molecular-weight fucoidan extracted from brown algae on bone biomaterial osteoconductive properties.
Sylvie Changotade (2008)
The Pharmacokinetics of Fucoidan after Topical Application to Rats
Olga N Pozharitskaya (2019)
A decade of change in the seaweed hydrocolloids industry
Harris J. Bixler (2010)
Wound dressings – a review
Selvaraj Dhivya (2015)
Electrospun scaffolds composing of alginate, chitosan, collagen and hydroxyapatite for applying in bone tissue engineering
Chia Cherng Yu (2013)
Rapid-prototyped PCL/fucoidan composite scaffolds for bone tissue regeneration: design, fabrication, and physical/biological properties
Gyuhyun Jin (2011)
The chromene sargachromanol E inhibits ultraviolet A-induced ageing of skin in human dermal fibroblasts.
J-A Kim (2013)
Isolation and chemical characterization of algal polysaccharides from the green seaweed Ulva clathrata (Roth) C. Agardh
Enrique Hernández-Garibay (2010)
Novel Sorghum bicolor (L.) seed polysaccharide structure, hemolytic and antioxidant activities, and laser burn wound healing effect.
Sirine Ben Slima (2019)
Study on the potential of RGD- and PHSRN-modified alginates as artificial extracellular matrices for engineering bone
R. Nakaoka (2013)
Fabrication of electrospun biocomposites comprising polycaprolactone/fucoidan for tissue regeneration.
Ji Seok Lee (2012)
Controlled activity of mouse astrocytes on electrospun PCL nanofiber containing polysaccharides from brown seaweed
Sang-Myung Jung (2012)
Enhanced effects of curcumin encapsulated in polycaprolactone-grafted oligocarrageenan nanomicelles, a novel nanoparticle drug delivery system.
Latufa Youssouf (2019)
Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps.
Xiaojun Yu (2003)
Combination of drugs and carriers in drug delivery technology and its development
Ying Du (2019)
Development of new chitosan/carrageenan nanoparticles for drug delivery applications.
Ana Grenha (2010)
Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer.
Kalimuthu Senthilkumar (2013)
This paper is referenced by
Biologically active macromolecules: Extraction strategies, therapeutic potential and biomedical perspective.
Muhammad Bilal (2020)
Seaweeds as a Functional Ingredient for a Healthy Diet
Rocío Peñalver (2020)