Online citations, reference lists, and bibliographies.
← Back to Search

Marine Cyanobacteria And Microalgae Metabolites—A Rich Source Of Potential Anticancer Drugs

Arijit Mondal, S. Bose, S. Banerjee, Jayanta Kumar Patra, Jai Malik, S. Mandal, Kaitlyn L Kilpatrick, G. Das, Rout George Kerry, C. Fimognari, Anupam Bishayee
Published 2020 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.
This paper references
10.1038/46023
The insidious effect of diatoms on copepod reproduction
A. Miralto (1999)
Two cytotoxic stereo isomers
H. Gross (2011)
10.1016/0040-4039(95)00030-G
ABSOLUTE CONFIGURATION OF CURACIN A, A NOVEL ANTIMITOTIC AGENT FROM THE TROPICAL MARINE CYANOBACTERIUM LYNGBYA MAJUSCULA
D. Nagle (1995)
10.1016/j.ejmech.2011.05.049
Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro.
T. Chang (2011)
10.2174/156802610792928103
Reversal of multidrug resitance by natural substances from plants.
J. Molnár (2010)
10.3390/md18070356
Anticancer Compounds Derived from Marine Diatoms
Hanaa Ali Hussein (2020)
10.2174/1381612033454883
Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery.
D. Kitts (2003)
10.3389/fmars.2017.00006
Marine Polysaccharide Sulfatases
W. Helbert (2017)
10.1016/S0040-4020(99)00833-9
Calothrixins A and B, novel pentacyclic metabolites from Calothrix cyanobacteria with potent activity against malaria parasites and human cancer cells
R. Rickards (1999)
10.1023/A:1002405815493
Marine pharmacology
D. Faulkner (2000)
Alkaloids—Secrets of Life: Alkaloids Chemistry, Biological Significance, Applications and Ecological Role; Elsevier: Amsterdam, The Netherlands
T. Aniszewski (2007)
10.1021/np700717s
Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii.
Susan Matthew (2008)
10.1021/JO0478858
The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena.
Bingnan Han (2005)
10.1016/S0968-0896(02)00014-7
New apratoxins of marine cyanobacterial origin from Guam and Palau.
H. Luesch (2002)
10.1016/j.saa.2017.06.041
Different molecular organization of two carotenoids, lutein and zeaxanthin, in human colon epithelial cells and colon adenocarcinoma cells.
W. Grudzinski (2018)
10.1016/j.ejphar.2019.172472
Alkaloids for cancer prevention and therapy: Current progress and future perspectives.
A. Mondal (2019)
malaria parasites and human cancer cells
S. Xu (1999)
10.1021/NP030050S
Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp.
P. Williams (2003)
10.1016/j.phrs.2009.01.017
Natural compounds for cancer treatment and prevention.
S. Nobili (2009)
10.3390/md12063660
Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound
T. Sugawara (2014)
10.1200/jco.2004.22.14_suppl.7530
Phase II study of synthadotin (SYN-D; ILX651) administered daily for 5 consecutive days once every 3 weeks (qdx5q3w) in patients (Pts) with inoperable locally advanced or metastatic melanoma.
S. Ebbinghaus (2004)
Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors.
T. Madden (2000)
10.1124/JPET.102.036350
The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore
C. Stevenson (2002)
10.1002/CHEM.200600599
Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities.
D. Ma (2006)
10.4155/fmc.11.118
Marine natural products: a new wave of drugs?
R. Montaser (2011)
10.3390/md9020196
Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae
Guangling Jiao (2011)
10.2174/1389203711314030009
Beneficial effect of peptides from microalgae on anticancer.
Kyong-Hwa Kang (2013)
10.1016/J.TETLET.2009.12.041
Isolation and structure of koshikalide, a 14-membered macrolide from the marine cyanobacterium Lyngbya sp.
Arihiro Iwasaki (2010)
receptor degradation in breast cancer
S. N. Fedorov (2013)
10.4103/jnsbm.JNSBM_201_18
Marine pigmented bacteria: A prospective source of antibacterial compounds
C. Ramesh (2019)
cyanobacterium Lyngbya majuscula from Guam
H. Luesch (2011)
10.1271/bbb.120631
Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells
Z. Zhang (2013)
10.3109/1040841X.2014.957640
Recent developments in therapeutic applications of Cyanobacteria
Rathinam Raja (2016)
10.3390/md16070233
Marine Carbohydrate-Based Compounds with Medicinal Properties
Ariana A. Vasconcelos (2018)
10.3390/nu11061226
Microalgal Derivatives as Potential Nutraceutical and Food Supplements for Human Health: A Focus on Cancer Prevention and Interception
Christian Galasso (2019)
10.3390/md12010255
Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development †
D. Newman (2014)
10.3389/fmicb.2017.02536
Marine Fungi: A Source of Potential Anticancer Compounds
S. K. Deshmukh (2018)
10.1021/np1005407
Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium.
K. Malloy (2011)
10.1021/np1004032
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.
Susan Matthew (2010)
10.1021/ja7110064
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
Kanchan Taori (2008)
10.1021/np100467d
Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida.
Lilibeth A. Salvador (2010)
10.1007/BF02684014
Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases
C. Stevenson (2007)
10.1002/psc.3015
Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting
C. Weiss (2017)
10.1007/BF00249096
Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria
G. Patterson (2004)
10.3390/molecules22071037
An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs
Verónica Ruiz-Torres (2017)
cyanobacteria Phormidium sp., from Florida
T. T. Chang (2010)
cyanobacterium Lyngbya bouillonii
G. Navarro (2002)
10.3892/ijmm.2013.1409
Induction of apoptosis and the regulation of ErbB signaling by laminarin in HT-29 human colon cancer cells
Hee-Kyoung Park (2013)
10.1021/NP020184Q
Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp.
P. Williams (2002)
10.3136/NSKKK.55.304
Safety Evaluation of Fucoxanthin purified from Undaria pinnatifida
Takashi Kadekaru (2008)
10.3390/md9050819
Antiproliferative Activity of Violaxanthin Isolated from Bioguided Fractionation of Dunaliella tertiolecta Extracts
Virginie Pasquet (2011)
10.1007/s11010-013-1651-5
Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells
P. Ganesan (2013)
10.1016/j.chembiol.2010.10.017
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
S. Sato (2011)
Oversulfation of fucoidan
S. Koyanagi (2008)
Total synthesis of the cyclodepsipeptideapratoxin A and its analogues and assessment of their biological activities
D. Ma (2006)
New cytotoxicdepsipeptides from the marine cyanobacterium Symploca sp
P G Williams (2003)
10.1016/0163-7258(91)90028-K
Current progress on nucleoside antibiotics.
K. Isono (1991)
10.1016/j.biopha.2018.12.069
Microalgae in modern cancer therapy: Current knowledge.
M. A. Abd El-Hack (2019)
10.1371/journal.pone.0065250
Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells
A. Hau (2013)
10.2307/1313538
Getting to the Bottom of Marine Biodiversity: Sedimentary Habitats: Ocean bottoms are the most widespread habitat on Earth and support high biodiversity and key ecosystem services
P. Snelgrove (1999)
10.3390/md11124876
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
S. Fedorov (2013)
10.1016/j.phymed.2010.05.005
Anti-angiogenic effect of siphonaxanthin from green alga, Codium fragile.
P. Ganesan (2010)
10.1021/NP50072A021
Tolytoxin and new scytophycins from three species of Scytonema.
S. Carmeli (1990)
10.1021/NP030014T
Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
M. T. Davies-Coleman (2003)
World Health Organization. WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All
(2020)
10.1016/0958-1669(95)80049-2
New dimensions in natural products research: cultured marine microorganisms
B. Davidson (1995)
10.1002/anie.201000728
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.
Tobias A. M. Gulder (2010)
10.3390/md11010146
Beneficial Effects of Marine Algal Compounds in Cosmeceuticals
Noel Vinay Thomas (2013)
10.1002/ijc.10982
The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog
S. Mooberry (2003)
10.3390/md14010017
Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation
S. Xu (2016)
10.3892/ol.2014.1952
Laminarin-induced apoptosis in human colon cancer LoVo cells
C. Ji (2014)
10.1177/001452469700800907
A Comparison
Marshall B. Lang (1897)
10.1016/j.chembiol.2016.04.008
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.
A. Paatero (2016)
10.1124/MOL.53.1.62
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
P. Verdier-Pinard (1998)
10.1517/13543784.12.8.1367
Marine-derived anticancer agents in clinical trials
G. Schwartsmann (2003)
10.1002/(SICI)1097-0215(19971104)73:3<440::AID-IJC20>3.0.CO;2-F
Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent
S. Mooberry (1997)
10.1007/s10600-010-9510-z
Structural characteristics and antitumor activity of a new chrysolaminaran from the diatom alga Synedra acus
M. I. Kusaikin (2010)
10.1073/pnas.0712198105
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8
W. Wrasidlo (2008)
10.1021/NP000456U
Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.
H. Luesch (2001)
10.1016/j.sjbs.2017.11.003
Microalgae metabolites: A rich source for food and medicine
R. Sathasivam (2019)
10.3390/md16060179
Developments of Cyanobacteria for Nano-Marine Drugs: Relevance of Nanoformulations in Cancer Therapies
V. Bajpai (2018)
Chandrananimycins A approximately C: production of novel anticancer antibiotics from a marine Actinomadura sp. isolate M048 by variation of medium composition and growth conditions.
R. P. Maskey (2003)
10.1016/J.JEP.2005.05.011
Plants as a source of anti-cancer agents.
G. Cragg (2005)
10.1021/NP0102253
Isolation and structure determination of obyanamide, a novel cytotoxic cyclic depsipeptide from the marine cyanobacterium Lyngbya confervoides.
P. Williams (2002)
10.1016/j.carbpol.2015.06.020
Structure and anticancer activity in vitro of sulfated galactofucan from brown alga Alaria angusta.
R. V. Menshova (2015)
10.1021/JA00338A031
Acutiphycin and 20,21-didehydroacutiphycin, new antineoplastic agents from the cyanophyte Oscillatoria acutissima
J. Barchi (1984)
Compendium of chemical terminology
V. Gold (1987)
10.1021/jo1013564
Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides
J. Kwan (2010)
10.7164/ANTIBIOTICS.41.1711
Nucleoside antibiotics: structure, biological activity, and biosynthesis.
K. Isono (1988)
The wewakpeptins, cyclic depsipeptides from aPapua
B. Han (2011)
Alkaloids-Secrets of Life: Alkaloids Chemistry, Biological Significance, Applications and Ecological Role
T Aniszewski (2007)
10.1016/j.phytochem.2011.08.019
Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula.
Ashootosh Tripathi (2011)
10.1007/s11274-019-2745-3
Microalgae polysaccharides: the new sustainable bioactive products for the development of plant bio-stimulants?
Mutale-Joan Chanda (2019)
10.2174/138527210792927708
Plant Natural Products in Anticancer Drug Discovery
P. Grothaus (2010)
10.2174/0929867043364982
Advanced preclinical and clinical trials of natural products and related compounds from marine sources.
D. Newman (2004)
10.3390/md17060320
Natural Products from Cyanobacteria: Focus on Beneficial Activities
J. Demay (2019)
10.1021/np1006839
Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam.
R. Montaser (2011)
10.1158/1078-0432.CCR-15-2616
Phase I Clinical Trial of Marizomib (NPI-0052) in Patients with Advanced Malignancies Including Multiple Myeloma: Study NPI-0052-102 Final Results
S. Harrison (2016)
10.1016/j.chembiol.2011.12.014
Lessons from the past and charting the future of marine natural products drug discovery and chemical biology.
W. Gerwick (2012)
10.1007/978-3-642-22144-6_179
Alkaloids of Marine Macroalgae
Kasim Cemal Güven (2013)
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.
A. Blokhin (1995)
10.1007/s10637-015-0303-x
Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts
J. Serrill (2015)
10.1007/s12010-011-9178-2
Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity
S. Ermakova (2011)
10.1002/cbic.201000070
Evolved Diversification of a Modular Natural Product Pathway: Apratoxins F and G, Two Cytotoxic Cyclic Depsipeptides from a Palmyra Collection of Lyngbya bouillonii
Kevin Tidgewell (2010)
10.1021/NP0202879
Lyngbyaloside B, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp.
H. Luesch (2002)
10.1093/carcin/bgs396
Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer.
H. Hsu (2013)
10.1248/CPB.50.1630
Isolation and characterization of dinochrome A and B, anti-carcinogenic active carotenoids from the fresh Water red tide Peridinium bipes.
T. Maoka (2002)
10.1016/j.lfs.2013.08.002
Health applications of bioactive compounds from marine microalgae.
Maria Filomena de Jesus Raposo (2013)
10.1002/ijc.23860
Antiadult T‐cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol
Chie Ishikawa (2008)
10.1021/ol9020546
Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium Lyngbya sp.: isolation, stereostructure, and biological activity.
Toshiaki Teruya (2009)
10.3390/md10122795
The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview
W. Wang (2012)
10.1016/J.FOODRES.2018.11.043
Carotenoid profiling of five microalgae species from large-scale production.
Gabriella Di Lena (2019)
10.1371/journal.pone.0050624
Fucoidan from Seaweed Fucus vesiculosus Inhibits Migration and Invasion of Human Lung Cancer Cell via PI3K-Akt-mTOR Pathways
H. Lee (2012)
10.1093/JN/131.12.3303
Carotenoids affect proliferation of human prostate cancer cells.
E. Kotake-Nara (2001)
Siphonaxanthin, a marine algal carotenoids from green algae, effectively induces apoptosis in human leukemia (HL-60) cells
P. Ganesan (2011)
10.7164/ANTIBIOTICS.56.622
Chandrananimycins A~C : Production of Novel Anticancer Antibiotics from a Marine Actinomadura sp. Isolate M048 by Variation of Medium Composition and Growth Conditions
R. P. Maskey (2003)
10.1016/J.TET.2012.05.038
Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides
Maho Morita (2012)
10.1080/01635580802567133
Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12
T. Nagamine (2009)
10.1128/AEM.70.6.3305-3312.2004
Morphological, Chemical, and Genetic Diversity of Tropical Marine Cyanobacteria Lyngbya spp. and Symploca spp. (Oscillatoriales)
R. Thacker (2004)
10.1002/AJH.20182
Fucoidan induces apoptosis of human HS‐Sultan cells accompanied by activation of caspase‐3 and down‐regulation of ERK Pathways
Y. Aisa (2005)
10.1371/journal.pone.0101220
Diatom-Derived Polyunsaturated Aldehydes Activate Cell Death in Human Cancer Cell Lines but Not Normal Cells
C. Sansone (2014)
10.1021/NP010526C
Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii.
L. T. Tan (2002)
10.1021/np700738k
Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,).
G. Pettit (2008)
10.3390/md8061779
Bacterial Exopolysaccharides from Extreme Marine Habitats: Production, Characterization and Biological Activities
A. Poli (2010)
Fucoidan from seaweed Fucusvesiculosus inhibits migration and invasion
H. Lee (2013)
Ulongapeptin, a cytotoxiccyclicdepsipeptide
P. G. Williams (2003)
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbyamajuscula
D J Edwards (2004)
10.1007/s00284-019-01698-5
Metagenomics Approaches in Discovery and Development of New Bioactive Compounds from Marine Actinomycetes
Gyana Prakash Mahapatra (2019)
10.1016/J.CCR.2005.10.013
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
D. Chauhan (2005)
10.12691/BB-3-1-2
Biomedical Significance of Terpenes: An Insight
S. Kandi (2015)
anti-angiogenic and antitumor activities
T. Nagamine (2003)
10.1016/J.JFF.2013.10.011
APOPTOTIC ANTICANCER ACTIVITY OF A NOVEL FATTY ALCOHOL ESTER ISOLATED FROM CULTURED MARINE DIATOM, Phaeodactylum tricornutum
K. Samarakoon (2014)
10.1016/j.chembiol.2015.07.014
Previously Uncultured Marine Bacteria Linked to Novel Alkaloid Production.
E. J. Choi (2015)
10.3390/md13074006
Marine Peptides: Bioactivities and Applications
R. Cheung (2015)
10.1021/ja801383f
Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp.
Rebecca A. Medina (2008)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
10.1016/j.bbagen.2011.02.008
Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells.
P. Ganesan (2011)
10.1002/CHIN.200612196
Isolation and Structure of Five Lyngbyabellin Derivatives from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula.
Bingnan Han (2006)
10.1002/CHIN.200830190
Total Structure Determination of Grassypeptolide, a New Marine Cyanobacterial Cytotoxin.
J. Kwan (2008)
10.1021/NP980138J
Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue.
R. Banker (1998)
Two cytotoxic stereo isomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula
H Gross (2010)
Interaction of cryptophycin 1 with
K. Kerksiek (1998)
10.1016/J.PROCBIO.2009.02.010
Functional, bioactive and antioxidative properties of hydrolysates obtained from cod (Gadus morhua) backbones
R. Šližytė (2009)
Isolation and characterization of dinochrome A and B, anti-carcinogenic
T. Maoka (2014)
10.1246/BCSJ.20150117
Structures and Biological Activities of Novel Biselyngbyaside Analogs Isolated from the Marine Cyanobacterium Lyngbya sp.
A. Watanabe (2015)
10.1039/np9860300001
Marine natural products.
D. Faulkner (2000)
cyanobacterium Symploca sp
T. L. Simmons (2002)
10.1016/J.CHEMBIOL.2004.03.030
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula.
D. Edwards (2004)
10.3390/md18030152
Laminarin-Derived from Brown Algae Suppresses the Growth of Ovarian Cancer Cells via Mitochondrial Dysfunction and ER Stress
H. Bae (2020)
10.3390/molecules17089947
Laminarin Induces Apoptosis of Human Colon Cancer LOVO Cells through a Mitochondrial Pathway
Y. Ji (2012)
10.1021/NP010560R
Malevamide D: isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydnoides.
F. D. Horgen (2002)
10.1021/NP034001R
The structure of Palau'amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya.
P. Williams (2003)
Marine polysaccharide sulfatases. Front
W Helbert (2006)
10.3390/ijms19030919
Therapeutic Properties and Biological Benefits of Marine-Derived Anticancer Peptides
H. Kang (2018)
10.3136/FSTR.5.243
Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60
M. Hosokawa (1999)
10.1021/np8007232
Calothrixins, a new class of human DNA topoisomerase I poisons.
Qasim A. Khan (2009)
10.1021/JA0715187
Nigricanosides A and B, antimitotic glycolipids isolated from the green alga Avrainvillea nigricans collected in Dominica.
D. Williams (2007)
10.1021/OL025759P
Caylobolide A, a unique 36-membered macrolactone from a Bahamian Lyngbya majuscula.
J. MacMillan (2002)
10.1016/j.carbpol.2016.07.103
The comparison of structure and anticancer activity in vitro of polysaccharides from brown algae Alaria marginata and A. angusta.
Roza V Usoltseva Menshova (2016)
Apratoxin kkills cells by direct blockade of the Sec61 protein translocation
A. O. Paatero (2016)
10.1111/j.1349-7006.1997.tb00383.x
Antitumor Activity of TZT‐1027, a Novel Doiastatin 10 Derivative
M. Kobayashi (1997)
10.1016/0014-5793(95)01271-0
Interaction of cryptophycin 1 with tubulin and microtubules
K. Kerksiek (1995)
10.1016/j.tips.2010.02.005
The odyssey of marine pharmaceuticals: a current pipeline perspective.
A. M. Mayer (2010)
10.1016/j.bmc.2014.02.035
Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function.
Jessica J Field (2014)
10.1021/np200077f
Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera.
E. Mevers (2011)
10.1002/CHIN.199526275
Absolute Configuration of Curacin A, a Novel Antimitotic Agent from the Tropical Marine Cyanobacterium Lyngbya majuscula.
D. Nagle (1995)
10.1533/9780857098689.2.307
Anticancer agents derived from marine algae
N. Boopathy (2013)
10.3390/md13052834
The Effect of Dissolved Polyunsaturated Aldehydes on Microzooplankton Growth Rates in the Chesapeake Bay and Atlantic Coastal Waters
P. Lavrentyev (2015)
10.1021/np200906s
Natural products as sources of new drugs over the 30 years from 1981 to 2010.
D. Newman (2012)
10.3390/md17090491
Marine Natural Products: A Source of Novel Anticancer Drugs
Shaden A. M. Khalifa (2019)
10.1016/J.TET.2010.11.106
Revised structure and structure–activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp.
H. Sasaki (2011)
10.1533/9780857098689
Functional ingredients from algae for foods and nutraceuticals.
H. Domínguez (2013)
10.3390/md17060329
Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets
R. B. Pereira (2019)
10.3390/md13031552
Kalkitoxin Inhibits Angiogenesis, Disrupts Cellular Hypoxic Signaling, and Blocks Mitochondrial Electron Transport in Tumor Cells
J. Morgan (2015)
Malyngamide 2, an oxidized
K. L. Malloy (2008)
10.1200/JCO.2004.22.90140.3068
Phase (Ph) I evaluation of the dolastatin analogue synthadotin (SYN-D; ILX651): Pooled data analysis of three alternate schedules in patients (pts) with advanced solid tumors.
L. Hammond (2004)
10.3390/md11030747
Chondroitin Sulfate, Hyaluronic Acid and Chitin/Chitosan Production Using Marine Waste Sources: Characteristics, Applications and Eco-Friendly Processes: A Review
J. Vázquez (2013)
10.1021/np100442x
Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.
Ashootosh Tripathi (2010)
10.1155/2010/214186
Anticancer Drugs from Marine Flora: An Overview
N. Sithranga Boopathy (2010)
10.3390/md12125817
Marine Nucleosides: Structure, Bioactivity, Synthesis and Biosynthesis
Riming Huang (2014)
10.3390/12030582
Proteasome and NF-kappaB inhibiting phaeophytins from the green alga Cladophora fascicularis.
Xinping Huang (2007)
10.1007/s10517-007-0226-4
Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga
T. V. Alekseyenko (2007)
10.1016/j.amepre.2013.10.029
Age and cancer risk: a potentially modifiable relationship.
M. White (2014)
10.1016/j.carres.2011.09.034
Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity.
O. S. Vishchuk (2011)
Natural Products from Cyanobacteria
J. Demay (2019)
Bioactive marine nucleosides
D. Bhakuni (2005)
10.1016/j.foodchem.2018.05.104
An efficient one-step scheme for the purification of major xanthophyll carotenoids from lettuce, and assessment of their comparative anticancer potential.
R. Saini (2018)
Reversal of multidrug resistance of cancer cells in vitro: modification of drug resistance by selected carotenoids.
N. Gyémánt (2006)
10.1021/NP030212K
Komodoquinone A, a novel neuritogenic anthracycline, from marine Streptomyces sp. KS3.
T. Itoh (2003)
10.1021/NP030114Z
The isolation and structure elucidation of Tasiamide B, a 4-amino-3-hydroxy-5-phenylpentanoic acid containing peptide from the marine Cyanobacterium Symploca sp.
P. Williams (2003)
10.1111/j.1349-7006.2000.tb01022.x
TZT‐1027, an Antimicrotubule Agent, Attacks Tumor Vasculature and Induces Tumor Cell Death
M. Otani (2000)
10.3390/md11124698
Shellfish Toxins Targeting Voltage-Gated Sodium Channels
F. Zhang (2013)
10.1021/np900428h
Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula.
Masatoshi Taniguchi (2010)
10.3390/ijms16036018
The Effects of Marine Carbohydrates and Glycosylated Compounds on Human Health
Heekyoung Kang (2015)
Palauan marine cyanobacterium Lyngbya sp
L. A. Salvador (2003)
10.3389/fchem.2014.00020
Cancer wars: natural products strike back
Christine Basmadjian (2014)
10.1016/j.fct.2008.01.025
Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells.
N. Y. Lee (2008)
10.1021/NP000462Q
New lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula.
J. I. Jiménez (2001)
10.1016/J.MARENVRES.2004.03.022
Oxidative damage to DNA: an immunohistochemical approach for detection of 7,8-dihydro-8-oxodeoxyguanosine in marine organisms.
N. Machella (2004)
10.1002/ejoc.201200691
Lyngbyabellins K-N from Two Palmyra Atoll Collections of the Marine Cyanobacterium Moorea bouillonii.
Hyukjae Choi (2012)
10.3390/molecules23061371
Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis
Carmen Sadaka (2018)
10.1124/jpet.110.172387
Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor
Yanxia Liu (2010)
10.1021/NP000316K
Isolation and structure determination of nostocyclopeptides A1 and A2 from the terrestrial cyanobacterium Nostoc sp. ATCC53789.
T. Golakoti (2001)
10.3390/md11125130
Fucoxanthin: A Marine Carotenoid Exerting Anti-Cancer Effects by Affecting Multiple Mechanisms
S. R. Kumar (2013)
10.1016/j.carbpol.2013.08.037
Structure, enzymatic transformation and anticancer activity of branched high molecular weight laminaran from brown alga Eisenia bicyclis.
Roza V. Menshova (2014)
10.1007/s10989-018-9766-x
Review on the Bioactive Peptides from Marine Sources: Indication for Health Effects
Raheleh Ghanbari (2018)
10.3390/md15040124
Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications
Rushikesh Sable (2017)
10.1021/NP020582T
Tasipeptins A and B: new cytotoxic depsipeptides from the marine cyanobacterium Symploca sp.
P. Williams (2003)
10.1021/NP0503911
Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula.
Bingnan Han (2006)
10.1023/A:1006148127527
Cryptophycin 1 cellular levels and effects in vitro using L1210 cells
B. J. Foster (2004)
10.1016/J.JCHROMB.2003.11.005
Bioactive peptides from marine sources: pharmacological properties and isolation procedures.
A. Aneiros (2004)
10.21608/ejchem.2019.16055.1975
Pharmacological Property of Pentacyclic Triterpenoids
S. Banerjee (2019)
10.1039/C9MD00061E
Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacterium Pseudoalteromonas citrea.
Katherine J Picott (2019)
10.1111/j.1751-7915.2010.00221.x
Natural products for cancer chemotherapy
A. Demain (2011)
10.1016/J.TETLET.2006.03.082
Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium
T. Simmons (2006)
10.1016/j.carbpol.2017.10.006
Structure and anticancer activity of native and modified polysaccharides from brown alga Dictyota dichotoma.
R. Usoltseva (2018)
10.1016/S0006-2952(02)01478-8
Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities.
S. Koyanagi (2003)
10.1007/s00018-006-6264-7
Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells
A. Catassi (2006)
10.1016/j.phytochem.2010.07.001
Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula.
H. Gross (2010)
10.1021/np9005184
Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula.
M. Gutiérrez (2010)
10.4103/0975-7406.171700
Exploring the ocean for new drug developments: Marine pharmacology
H. Malve (2016)
10.1016/j.carbpol.2018.11.008
Laminaran from brown alga Dictyota dichotoma and its sulfated derivative as radioprotectors and radiosensitizers in melanoma therapy.
O. Malyarenko (2019)
10.1021/OL050188X
Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria.
Eric H. Andrianasolo (2005)
10.3389/fcimb.2014.00005
Marine medicinal glycomics
V. Pomin (2014)
10.1016/0006-2952(90)90613-P
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
R. Bai (1990)
Fucoidans from brown
S. Ermakova (2011)
10.1021/np200076t
Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam.
Lilibeth A. Salvador (2011)
10.1016/J.FOODRES.2010.10.017
Antioxidant and angiotensin converting enzyme (ACE) inhibitory activities of cocoa (Theobroma cacao L.) autolysates
B. Sarmadi (2011)
10.5483/BMBRep.2014.47.8.153
Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells
Y. Kim (2014)
10.12691/JFNR-4-3-2
Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice
Z. Kong (2016)
10.1016/J.CARBPOL.2010.01.052
Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida
A. Synytsya (2010)
10.3389/fmars.2018.00359
The Challenge of Implementing the Marine Ecosystem Service Concept
M. Townsend (2018)
10.2174/1381612043384853
Chemistry and biology of curacin A.
P. Wipf (2004)
10.1021/ol900579k
Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium Lyngbya sp.
Toshiaki Teruya (2009)
10.1246/CL.130960
Biselyngbyolide B, a Novel ER Stress-inducer Isolated from the Marine Cyanobacterium Lyngbya sp.
O. Ohno (2014)
10.3892/etm.2013.1277
Sulfated modification and anti-tumor activity of laminarin
C. Ji (2013)
10.3390/md10102181
Marine Cyanobacteria Compounds with Anticancer Properties: A Review on the Implication of Apoptosis
M. Costa (2012)
Therapeutic importance of peptides from marine source: A mini review
S. Shukla (2016)
10.3322/canjclin.49.1.33
Global cancer statistics
D. Parkin (1999)
10.1016/j.phytochem.2011.07.014
Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam.
R. Montaser (2011)
10.1093/ANNONC/11.SUPPL_3.235
Marine organisms and other novel natural sources of new cancer drugs.
G. Schwartsmann (2000)
10.1021/JO00085A006
Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majuscula
W. H. Gerwick (1994)
10.3389/fmars.2016.00068
Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anticancer, Anti-Diabetes, and Antibacterial Activities
C. Lauritano (2016)
10.1021/ACS.ESTLETT.5B00116
Isolation of Polycavernoside D from a Marine Cyanobacterium
G. Navarro (2015)
10.1016/j.carbpol.2017.08.044
Polysaccharides from brown algae Sargassum duplicatum: the structure and anticancer activity in vitro.
R. Usoltseva (2017)
The challenge of implementing the marine ecosystem services concept. Front
M Townsend (2018)
10.2174/187152507779315778
Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae.
C. Boisson-Vidal (2007)



Semantic Scholar Logo Some data provided by SemanticScholar