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Antibacterial, Antifungal And Cytotoxic Activities Of Two Flavonoids From Retama Raetam Flowers

H. Edziri, M. Mastouri, M. Mahjoub, Z. Mighri, A. Mahjoub, L. Verschaeve
Published 2012 · Biology, Medicine

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We have investigated the antibacterial, antifungal and cytotoxic activities of two flavonoids isolated from Retama raetam flowers using the disc diffusion and micro-dilution broth methods. The cytotoxic activity was tested against Hep-2 cells using the MTT assay. The compounds licoflavone C (1) and derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81–15.62 µg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 µg/mL) was for example found with compound 2. The tested compounds also showed strong cytotoxicity against Hep-2 cells. These two compounds may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
Sample Availability: Samples of the compounds 1 and 2 are available from the authors

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