Online citations, reference lists, and bibliographies.
← Back to Search

Synthesis, Tautomeric Structure And Antimicrobial Activity Of 3-Arylhydrazono-4-phenyl-[1,2,4]-triazepino[2,3-a]quinazoline-2,7(1H)-diones

T. Farghaly, M. M. Edrees, Mosselhi A. Mosselhi
Published 2012 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
A simple strategy for the synthesis of the hitherto unreported 3-arylazo-4-phenyl- [1,2,4]triazepino[2,3-a]quinazoline-2,7(1H)-diones is described. Spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. The antimicrobial activity of the newly synthesized compounds was also evaluated. The results indicated that some of these compounds have moderate activity towards bacteria.
This paper references
10.1002/PRAC.19983400209
Tautomerism and Reactions of 1H‐1,2,4‐Triazole‐5‐thiones with Hydrazonoyl Halides
M. A. N. Mosselhi (1998)
10.1039/A804772C
New Synthetic Approaches to Fused Heterocyclo-quinazolines
A. Santagati (1999)
10.1016/0006-2952(95)02156-6
Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin.
E. Hamel (1996)
10.1016/J.TET.2008.03.096
Synthesis and tautomeric structure of 3,7-bis(arylazo)-6-methyl-2-phenyl-1H-imidazo[1,2-b]pyrazoles in ground and excited states
A. S. Shawali (2008)
10.1016/S0040-4020(01)86088-9
Reactions of 1,2-diaminobenzimidazoles with β-dicarbonyl compounds
C. Romano (1988)
10.1007/BF00581608
Synthesis and alkylation of 2-mercapto-4-quinazolone and the fungicidal activities of the compounds obtained
Kh. M. Shakhadoyatov (2004)
10.3390/molecules15042719
Access to Original Vinylic Chlorides in the Quinazoline Series via a Monoelectronic Transfer Reaction Approach
Martine Maillard-Boyer (2010)
10.1080/10426500210251
Synthesis and Tautomeric Structure of 7-Arylhydrazono-7H-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazines
M. A. Mosselhi (2002)
Synthesis and antiviral testing of certain derivatives of thiazolo
A E M Barghash (2004)
10.1002/JHET.5570210559
Synthesis and reactions of 2,3‐diamino‐4(3H)‐pyrimidinones and 3‐amino‐2‐hydrazino‐4(3H)‐pyrimidinones. I
J. Hlavka (1984)
10.1042/BJ3570275
Fatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cells.
X. Du (2001)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
10.1002/JCCS.201000013
Synthesis, Characterization and Crystal Structure of Some Novel 1-Aryl-2-Thioxo-2,3-Dihydro-1H-Quinazolin-4-Ones
A. Saeed (2010)
10.1002/JHET.5570120410
Recherches en série triazepine-1,2,4: 1 - détermination de la structure de la triazolotriazépinone obtenue par action de l'acétylacétate d'éthyle sur le diamino-3,4 triazole-1,2,4
E. M. Essassi (1975)
Sample Availability: Samples of the compounds 4 and 6 are available from the authors
Selective thromboxane synthetase inhibitors
P. E. Cross (1985)
10.1590/S0103-50532010000100009
Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines
R. Rohini (2010)
10.3184/030823408X339782
Synthesis and Tautomeric Structure of 3,6-bis(arylazo)pyrazolo [1,5-a]pyrimidine-5,7(4H,6H)-diones
A. S. Shawali (2008)
10.1016/S0014-827X(99)00038-5
Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a:4,3'-c]quinazolines: synthesis and antitoxoplasmosis effect.
A. A. El-tombary (1999)
10.4155/fmc.10.16
Novel fused quinazolinones: further studies on the anticonvulsant activity of 1,2,9,11-tetrasubstituted-7H-thieno[2´,3´:4,5]pyrimido[6,1-b]-quinazolin-7-one and 1,3,10,12-tetrasubstituted-8H-pyrido[2´,3´:4,5]pyrimido[6,1-b]quinazolin-8-one.
Sachin S Laddha (2010)
J. Med. Chem
(1986)
10.1016/S0040-4020(01)99223-3
The structures of some 5-pyrazolones and derived 4-arylazo-5-pyrazolones
R. Jones (1963)
10.1002/CHIN.199826167
Tautomerism and Reactions of 1H-1,2,4-Triazole-5-thiones with Hydrazonoyl Halides.
M. A. N. Mosselhi (1998)
10.1080/10426500500263706
Condensed Thioxocyclopentapyridine (Isoquinoline)-1,2,4-azines
K. Hassan (2006)
10.1002/HLCA.201000254
Purines. Part XVI : Syntheses, Properties, and Reactions of 8-Aminoxanthines
M. A. Mosselhi (2010)
PET quantification of 5-HT2A receptors in the human brain: a constant infusion paradigm with [18F]altanserin.
C. V. van Dyck (2000)
10.3184/030823407X237885
Synthesis and Tautomeric Structure of 2-arylazo-4H-imidazo[2,1-b][1,3,4]thiadiazines
Ahmad S. Shawali (2007)
10.1016/0002-9149(78)90853-6
New antiarrhythmic agents: amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil.
D. Zipes (1978)
10.1097/00006205-198607000-00006
New antiarrhythmic agents.
G. A. Pepper (1986)
10.3184/030823407780199522
Synthesis and Tautomeric Structure of the Azo-Coupling Products of 2-Methyl-7-Phenylpyrimido[1,2-b][1,2,4]triazepine-4,9(3H,5H)-dione
Ahmad S. Shawali (2007)
10.1515/znb-2002-0512
Synthesis and Tautomeric Structure of 1,2-Bis-(7-arylhydrazono-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)ethanes
Ahmad S. Shawali (2002)
10.1002/CHIN.198648194
New Antiarrhythmic Agents. 2,2,5,5‐Tetramethyl‐3‐pyrroline‐3‐carboxamides and 2,2,5,5‐Tetramethylpyrrolidine‐3‐carboxamides.
O. Hankovszky (1986)
10.1016/S0960-894X(01)00190-1
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones.
Y. Xia (2001)
10.3390/ECSOC-13-00222
Novel Fused quinazolinones: Further studies on the anticonvulsant activity of 1,2,9,11 tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]-quinazolin-7-one and 1,3,10,12- tetrasubstituted-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
S. Laddha (2009)
10.1021/JM00157A005
New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes.
O. Hankovszky (1986)
10.1016/S0223-5234(03)00085-0
Synthesis and primary cytotoxicity evaluation of 3-[[(3-phenyl-4(3H)-quinazolinone-2-yl)mercaptoacetyl]hydrazono]-1H-2-indolinones.
A. Gürsoy (2003)
10.1021/JM00148A009
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles.
P. Cross (1985)
10.3998/ARK.5550190.0009.E04
A facile one-pot MW approach for N3-(heteroaryl-2’-yl)- 2-thioxo-2,3-dihydro-1H-quinazolin-4-one
V. K. Tiwari (2008)
Synthesis and antiviral testing of certain derivatives of thiazolo[4,3-b]benzothiazoles, thiazolo[3′,4′:2,3][1,2,4]triazolo[5,1-b]-, {triazino [3,2-b]- and triazepino[3,2-b]}-quinazolines. Alex
A.E.M. Barghash (2004)
10.1615/INTJMEDMUSHR.V1.I4.40
Antibacterial Activity of Steroidal Compounds Isolated from Ganoderma applanatum (Pers.) Pat. (Aphyllophoromycetideae) Fruit Body
A. Smânia (1999)
10.1021/JM00161A045
3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone sodium salt (MDL 427): a new antiallergic agent.
N. Peet (1986)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar