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Structures Of Two New Flavonoids And Effects Of Licorice Phenolics On Vancomycin-Resistant Enterococcus Species

Eerdunbayaer, M. Orabi, H. Aoyama, T. Kuroda, T. Hatano
Published 2014 · Chemistry, Medicine

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Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
Sample Availability: Samples of the compounds 1

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