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Current Status Of Bioinks For Micro-Extrusion-Based 3D Bioprinting

Amit Panwar, L. Tan
Published 2016 · Chemistry, Medicine

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Recent developments in 3D printing technologies and design have been nothing short of spectacular. Parallel to this, development of bioinks has also emerged as an active research area with almost unlimited possibilities. Many bioinks have been developed for various cells types, but bioinks currently used for 3D printing still have challenges and limitations. Bioink development is significant due to two major objectives. The first objective is to provide growth- and function-supportive bioinks to the cells for their proper organization and eventual function and the second objective is to minimize the effect of printing on cell viability, without compromising the resolution shape and stability of the construct. Here, we will address the current status and challenges of bioinks for 3D printing of tissue constructs for in vitro and in vivo applications.
This paper references
10.18063/IJB.2016.01.009
Polyelectrolyte gelatin-chitosan hydrogel optimized for 3D bioprinting in skin tissue engineering
Wei Long Ng (2016)
10.1111/j.1582-4934.2007.00138.x
Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy
D. Docheva (2008)
10.1039/C5RA21527G
Nano hydroxyapatite particles promote osteogenesis in a three-dimensional bio-printing construct consisting of alginate/gelatin/hASCs
Xiao-Fei Wang (2016)
10.1039/C3TB21280G
Development and characterisation of a new bioink for additive tissue manufacturing.
Ferry P. W. Melchels (2014)
10.1088/1758-5090/7/2/025001
Evaluation of an alginate-gelatine crosslinked hydrogel for bioplotting.
T. Zehnder (2015)
10.1089/ten.tec.2007.0392
Direct cell writing of 3D microorgan for in vitro pharmacokinetic model.
Robert C. Chang (2008)
Blood compatibility of polyethylene oxide
J. H. Lee (1995)
10.1016/j.biomaterials.2015.05.005
Epicardial application of cardiac progenitor cells in a 3D-printed gelatin/hyaluronic acid patch preserves cardiac function after myocardial infarction.
R. Gaetani (2015)
10.1038/ncomms4935
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
F. Pati (2014)
10.1016/J.BBRC.2006.03.106
Novel chitosan/collagen scaffold containing transforming growth factor-beta1 DNA for periodontal tissue engineering.
Y. Zhang (2006)
10.1089/ten.a.2007.0158
Three-dimensional fiber deposition of cell-laden, viable, patterned constructs for bone tissue printing.
N. E. Fedorovich (2008)
10.1002/anie.201409846
Biofabrication of cell-loaded 3D spider silk constructs.
Kristin Schacht (2015)
10.1016/j.biomaterials.2010.04.045
Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates.
A. Skardal (2010)
10.1038/nbt.3413
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
Hyun-wook Kang (2016)
10.1088/0960-1317/22/8/085014
Bioprinting of a mechanically enhanced three-dimensional dual cell-laden construct for osteochondral tissue engineering using a multi-head tissue/organ building system
Jin-Hyung Shim (2012)
Engineered polymeric biomaterials for tissue
S. W. Yee (2012)
10.1002/adma.201503310
Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink.
C. Colosi (2016)
10.1371/journal.pone.0037559
Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes
J. Liu (2012)
10.1021/acs.biomac.5b00188
3D Bioprinting Human Chondrocytes with Nanocellulose-Alginate Bioink for Cartilage Tissue Engineering Applications.
Kajsa Markstedt (2015)
10.1007/s10544-014-9915-8
Printing cell-laden gelatin constructs by free-form fabrication and enzymatic protein crosslinking
S. A. Irvine (2015)
10.1088/1758-5090/7/4/044106
Mesenchymal stem cell printing and process regulated cell properties.
Jessica Snyder (2015)
10.1088/1758-5082/6/3/035020
Biofabrication of tissue constructs by 3D bioprinting of cell-laden microcarriers.
R. Levato (2014)
10.1002/adhm.201500677
Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity.
A. Blaeser (2016)
10.1115/1.4024398
Direct Bioprinting of Vessel-Like Tubular Microfluidic Channels
Y. Zhang (2013)
10.1088/1758-5082/5/1/015001
Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications.
T. Xu (2013)
10.1002/anie.201411383
Rapid formation of a supramolecular polypeptide-DNA hydrogel for in situ three-dimensional multilayer bioprinting.
Chuang Li (2015)
10.1016/S0006-3495(02)75319-8
Micromechanical mapping of live cells by multiple-particle-tracking microrheology.
Y. Tseng (2002)
10.1088/1758-5090/7/4/044102
Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D.
Alan Faulkner-Jones (2015)
10.1016/j.actbio.2010.11.040
In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications.
L. Pescosolido (2011)
10.3990/1.9789036530194
Preparation of advanced porous structures by stereolithography for application in tissue engineering
F. Melchels (2010)
Design and fabrication of human skin by three-dimensional bioprinting Three-dimensional bioassembly tool for generating viable tissue-engineered constructs
V Lee (2004)
10.1002/biot.200900004
Characterization of cell viability during bioprinting processes.
K. Nair (2009)
10.1089/ten.a.2007.0004
Effects of dispensing pressure and nozzle diameter on cell survival from solid freeform fabrication-based direct cell writing.
Robert C. Chang (2008)
10.1039/C5TB00393H
An overview of the suitability of hydrogel-forming polymers for extrusion-based 3D-printing.
D. M. Kirchmajer (2015)
10.1016/S0168-3659(99)00027-9
Poly(ethylene glycol)-containing hydrogels in drug delivery.
N. Peppas (1999)
10.2174/2211542011201010041
Engineered Polymeric Biomaterials for Tissue Engineering
Yee Shan Wong (2012)
10.1088/1758-5090/8/1/014102
Three-dimensional bioprinting of multilayered constructs containing human mesenchymal stromal cells for osteochondral tissue regeneration in the rabbit knee joint.
Jin-Hyung Shim (2016)
10.1016/J.MICRON.2007.06.011
Atomic force microscopy probing of cell elasticity.
T. Kuznetsova (2007)
10.1038/nprot.2011.379
Materials fabrication from Bombyx mori silk fibroin
Danielle N Rockwood (2011)
10.1016/j.actbio.2014.09.023
Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs.
Sanskrita Das (2015)
3 D bioprinting human chondrocytes with nanocellulose – alginate bioink for cartilage tissue engineering applications
K. Markstedt (2015)
10.1016/j.actbio.2013.12.005
Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells.
B. Duan (2014)
10.1016/0079-6700(95)00011-4
Blood compatibility of polyethylene oxide surfaces
J. Lee (1995)
10.3390/ma8095271
Influence of Layer Thickness and Raster Angle on the Mechanical Properties of 3D-Printed PEEK and a Comparative Mechanical Study between PEEK and ABS
Wenzheng Wu (2015)
10.1016/J.MFGLET.2013.09.004
3D printing of cell-laden constructs for heterogeneous tissue regeneration
F. Pati (2013)
10.1088/1758-5082/3/2/021001
Bioprinting of hybrid tissue constructs with tailorable mechanical properties.
W. Schuurman (2011)
10.1089/ten.TEA.2014.0231
The stiffness and structure of three-dimensional printed hydrogels direct the differentiation of mesenchymal stromal cells toward adipogenic and osteogenic lineages.
D. F. Duarte Campos (2015)
10.1088/1758-5090/7/4/044101
Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation.
L. Ouyang (2015)
Poly (ethylene glycol)-containing hydrogels in drug
N. A. Peppas (1999)
10.1016/j.biomaterials.2010.05.078
The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat.
Jiashing Yu (2010)
10.1002/term.1682
An additive manufacturing-based PCL-alginate-chondrocyte bioprinted scaffold for cartilage tissue engineering.
Joydip Kundu (2015)
10.1088/1758-5082/6/3/035001
Three-dimensional printing of Hela cells for cervical tumor model in vitro.
Yu Zhao (2014)
10.1088/1758-5090/7/1/015010
3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions.
Liliang Ouyang (2015)
10.1016/j.actbio.2013.10.016
Tunable hydrogel composite with two-step processing in combination with innovative hardware upgrade for cell-based three-dimensional bioprinting.
S. Wüst (2014)
10.1002/adma.201305506
3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs.
David B. Kolesky (2014)
10.1016/j.tcb.2011.09.005
From 3D cell culture to organs-on-chips.
D. Huh (2011)
10.1073/pnas.1521342113
Three-dimensional bioprinting of thick vascularized tissues
David B. Kolesky (2016)
10.1089/TEN.TEA.2014.0231
The stiffness and structure of three-dimensional printed hydrogels direct the differentiation of mesenchymal stromal cells toward adipogenic and osteogenic lineages.
F Duarte CamposDaniela (2015)
10.1021/acs.chemrev.5b00303
Strategies and Molecular Design Criteria for 3D Printable Hydrogels.
Tomasz Jungst (2016)
10.3390/mi4020149
Freeform Fabrication of Magnetophotonic Crystals with Diamond Lattices of Oxide and Metallic Glasses for Terahertz Wave Control by Micro Patterning Stereolithography and Low Temperature Sintering
Soshu Kirihara (2013)
10.1089/TEN.TEC.2013.0335
Design and Fabrication of Human Skin by Three-Dimensional Bioprinting
LeeVivian (2014)
10.1088/1758-5082/6/2/024105
Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels.
L. Bertassoni (2014)
10.1088/1758-5090/7/3/035006
Nanostructured Pluronic hydrogels as bioinks for 3D bioprinting.
M. Müller (2015)
10.1089/TEN.2004.10.1566
Three-dimensional bioassembly tool for generating viable tissue-engineered constructs.
C. M. Smith (2004)
10.1089/aivt.2016.0002
Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development.
João Ribas (2016)
10.1089/ten.TEA.2009.0798
Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting.
A. Skardal (2010)
10.1002/adma.201405076
A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels.
Alexandra L. Rutz (2015)
10.1002/adma.201004625
Omnidirectional printing of 3D microvascular networks.
Willie Wu (2011)
10.1080/17452759.2015.1097053
Extrusion-based additive manufacturing of PEEK for biomedical applications
M. Vaezi (2015)
10.1016/j.actbio.2015.10.004
Phage as versatile nanoink for printing 3-D cell-laden scaffolds.
Doe-Young Lee (2016)
10.1021/je00015a050
Density and Viscosity of Concentrated Aqueous Solutions of Polyethylene Glycol
P. González-Tello (1994)
10.1016/j.biomaterials.2010.02.044
Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering.
JunMin Zhu (2010)
Gatenholm, P. 3D bioprinting human chondrocytes with nanocellulose–alginate bioink for cartilage tissue engineering applications
K. Markstedt (2015)
10.1016/j.actbio.2014.02.041
Covalent attachment of a three-dimensionally printed thermoplast to a gelatin hydrogel for mechanically enhanced cartilage constructs.
Kristel W. M. Boere (2014)
10.1016/j.biomaterials.2013.09.078
The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability.
T. Billiet (2014)
10.1177/0883911507079451
Rapid Prototyping Three-Dimensional Cell/Gelatin/Fibrinogen Constructs for Medical Regeneration:
Wei Xu (2007)
10.1016/j.actbio.2011.01.016
Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels.
Wenqian Xiao (2011)
10.1016/j.actbio.2014.06.034
Engineering alginate as bioink for bioprinting.
Jia Jia (2014)
10.1371/journal.pone.0118123
Modulation of Huh7.5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness
B. H. Lee (2015)
10.1515/pac-2015-0106
Biofabrication of 3D constructs: fabrication technologies and spider silk proteins as bioinks
Elise DeSimone (2015)
10.1016/j.biomaterials.2010.01.111
An cell-assembly derived physiological 3D model of the metabolic syndrome, based on adipose-derived stromal cells and a gelatin/alginate/fibrinogen matrix.
Mingen Xu (2010)
10.1088/1758-5090/7/4/045008
A novel bioprinting method and system for forming hybrid tissue engineering constructs.
Y. Shanjani (2015)
10.1080/17452759.2015.1097054
3D printing of smart materials: A review on recent progresses in 4D printing
Z. X. Khoo (2015)
10.1002/jbm.a.34326
Evaluation of hydrogels for bio-printing applications.
S. Murphy (2013)
10.1039/C5RA22028A
Efficient and controllable synthesis of highly substituted gelatin methacrylamide for mechanically stiff hydrogels
Bae Hoon Lee (2015)
10.1371/journal.pone.0136681
Scaffold-Free Tubular Tissues Created by a Bio-3D Printer Undergo Remodeling and Endothelialization when Implanted in Rat Aortae
M. Itoh (2015)
10.1088/1758-5082/5/3/035007
Biofabrication of multi-material anatomically shaped tissue constructs.
J. Visser (2013)
10.1016/j.biomaterials.2012.06.051
A hydrogel derived from decellularized dermal extracellular matrix.
M. T. Wolf (2012)
10.1089/ten.TEC.2013.0335
Design and fabrication of human skin by three-dimensional bioprinting.
V. Lee (2014)
10.1002/mabi.201200471
Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs.
W. Schuurman (2013)
10.1016/S0167-7799(03)00033-7
Organ printing: computer-aided jet-based 3D tissue engineering.
V. Mironov (2003)
10.1126/science.1226340
Printing and Prototyping of Tissues and Scaffolds
B. Derby (2012)
10.1016/j.biomaterials.2015.05.043
Biomimetic 3D tissue printing for soft tissue regeneration.
F. Pati (2015)
10.1088/1758-5082/6/2/024103
3D printing of composite tissue with complex shape applied to ear regeneration.
Jungseob Lee (2014)
10.1088/1758-5082/6/3/035004
A comparative study on collagen type I and hyaluronic acid dependent cell behavior for osteochondral tissue bioprinting.
J. Y. Park (2014)
10.1021/bm200178w
Hyaluronic acid and dextran-based semi-IPN hydrogels as biomaterials for bioprinting.
L. Pescosolido (2011)
10.1002/adma.201501234
Direct 3D Printing of Shear-Thinning Hydrogels into Self-Healing Hydrogels.
Christopher B. Highley (2015)
Inkjet Bioprinting as an Effective Tool for Tissue Fabrication
M. Nakamura (2006)
10.1089/ten.TEC.2011.0060
Biofabrication of osteochondral tissue equivalents by printing topologically defined, cell-laden hydrogel scaffolds.
N. E. Fedorovich (2012)
10.1016/j.biomaterials.2011.09.095
Controllable mineral coatings on PCL scaffolds as carriers for growth factor release.
Darilis Suárez-González (2012)
10.1002/adhm.201500229
Nanomechanics of Cells and Biomaterials Studied by Atomic Force Microscopy.
J. Kilpatrick (2015)
10.1088/1758-5090/8/1/014101
A liver-on-a-chip platform with bioprinted hepatic spheroids.
Nupura S. Bhise (2016)
10.1021/bm801463q
Evaluation of photocrosslinked Lutrol hydrogel for tissue printing applications.
N. E. Fedorovich (2009)
Acta Biomater
(2011)
10.3390/polym8020028
Magnetically-Responsive Hydrogels for Modulation of Chondrogenic Commitment of Human Adipose-Derived Stem Cells
Elena Geta Popa (2016)
10.1089/ten.TEA.2011.0543
Direct human cartilage repair using three-dimensional bioprinting technology.
X. Cui (2012)
10.18063/IJB.2016.01.008
Preventing bacterial adhesion on scaffolds for bone tissue engineering
Sandra Sanchez-Salcedo (2016)
10.3390/molecules17033243
Biodegradability and Biocompatibility Study of Poly(Chitosan-g-lactic Acid) Scaffolds
Z. Zhang (2012)



This paper is referenced by
10.3390/ma12172669
Sodium Alginate/Gelatine Hydrogels for Direct Bioprinting—The Effect of Composition Selection and Applied Solvents on the Bioink Properties
D. Bociaga (2019)
10.1063/1.5089245
Sedimentation study of bioink containing living cells
Heqi Xu (2019)
10.1016/J.JIEC.2018.05.049
3D printed cell-laden collagen and hybrid scaffolds for in vivo articular cartilage tissue regeneration
Youngwon Koo (2018)
10.1088/1758-5090/aacdc7
Optimization of gelatin-alginate composite bioink printability using rheological parameters: a systematic approach.
Teng Gao (2018)
10.1016/j.jmbbm.2019.06.014
Enhanced rheological behaviors of alginate hydrogels with carrageenan for extrusion-based bioprinting.
Myoung Hwan Kim (2019)
10.3390/ma13102278
3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication
Fei Xing (2020)
10.1080/17452759.2017.1338065
Organ regeneration: integration application of cell encapsulation and 3D bioprinting
Huanbao Liu (2017)
10.1002/ADFM.201901335
High‐Throughput Scaffold System for Studying the Effect of Local Geometry and Topology on the Development and Orientation of Sprouting Blood Vessels
Ariel A. Szklanny (2020)
10.1016/j.dental.2017.10.003
3D printed versus conventionally cured provisional crown and bridge dental materials.
Anthony Tahayeri (2018)
10.1016/j.bprint.2019.e00068
A high-throughput approach to compare the biocompatibility of candidate bioink formulations
M. Bedell (2020)
10.1002/ADEM.201900019
Bioprinting of Human Musculoskeletal Interface
Wenbin Luo (2019)
10.1007/s11033-020-05588-z
Evaluation of a cell-based osteogenic formulation compliant with good manufacturing practice for use in tissue engineering
D. Vivas (2020)
10.1063/1.5116371
Effects of printing conditions on cell distribution within microspheres during inkjet-based bioprinting
Heqi Xu (2019)
10.1016/j.actbio.2017.12.019
Extracellular matrix hydrogel therapies: In vivo applications and development.
Martin T. Spang (2018)
10.1016/j.actbio.2019.01.041
Development and quantitative characterization of the precursor rheology of hyaluronic acid hydrogels for bioprinting.
Emi A. Kiyotake (2019)
10.1016/j.jconrel.2017.10.038
Cyclodextrins as versatile building blocks for regenerative medicine
C. Alvarez-Lorenzo (2017)
10.1016/J.BBE.2017.12.001
Easy and affordable method for rapid prototyping of tissue models in vitro using three-dimensional bioprinting
Ashutosh Bandyopadhyay (2018)
10.1002/smll.201805510
3D Bioprinting: from Benches to Translational Applications.
M. Heinrich (2019)
10.1371/journal.pone.0216776
Layer-by-layer ultraviolet assisted extrusion-based (UAE) bioprinting of hydrogel constructs with high aspect ratio for soft tissue engineering applications
Pei Zhuang (2019)
10.1007/s41745-019-00129-5
An Overview of Hydrogel-Based Bioinks for 3D Bioprinting of Soft Tissues
Soumitra Das (2019)
10.3389/fphys.2017.00534
Microtissues Enhance Smooth Muscle Differentiation and Cell Viability of hADSCs for Three Dimensional Bioprinting
Jin Yipeng (2017)
10.1007/978-981-13-0950-2_1
3D Bioprinting of Adipose-Derived Stem Cells for Organ Manufacturing.
X. Wang (2018)
3D BIOPRINTING OF ORGANS AND TISSUES - a current status
J Ridhanya (2019)
10.1039/c9lc00612e
Deep, sub-wavelength acoustic patterning of complex and non-periodic shapes on soft membranes supported by air cavities.
Kuan-Wen Tung (2019)
10.3390/molecules25112468
The Polychromatic Woodburytype—Colour Tracking in Translucent, Patterned Gelatin/Pigment Films
D. Leech (2020)
10.2174/1381612825666190215122208
3D Printing in Personalized Drug Delivery.
Afsana (2018)
10.3390/polym11121924
3D Bioprinting of Novel Biocompatible Scaffolds for Endothelial Cell Repair
Yun Wu (2019)
10.1016/J.FOODCHEM.2019.05.134
Compositional and morphological analyses of wax in northern wild berry species.
Priyanka Trivedi (2019)
10.1016/j.tins.2017.11.001
Bioprinting for Neural Tissue Engineering
S. Knowlton (2018)
10.3390/gels4030069
Extrusion-Based 3D Printing of Poly(ethylene glycol) Diacrylate Hydrogels Containing Positively and Negatively Charged Groups
Sebastian Joas (2018)
10.3390/md17100555
Biomaterials Based on Marine Resources for 3D Bioprinting Applications
Yu Zhang (2019)
10.1002/adfm.201903055
Additive Manufacturing Approaches for Hydroxyapatite‐Reinforced Composites
M. Milazzo (2019)
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