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Michael Addition Reaction Catalyzed By Imidazolium Chloride To Protect Amino Groups And Construct Medium Ring Heterocycles

Dai, Tian, Li, Shang, Luo, Wang, Li, Zhang, Li, Yuan

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An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.