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Hyaluronate Functionalized Multi-Wall Carbon Nanotubes Filled With Carboplatin As A Novel Drug Nanocarrier Against Murine Lung Cancer Cells

Daniel Salas-Treviño, Odila Saucedo-Cárdenas, María de Jesús Loera-Arias, Humberto Rodríguez-Rocha, Aracely García-García, Roberto Montes-de-Oca-Luna, Edgar I. Piña-Mendoza, Flavio F. Contreras-Torres, Gerardo García-Rivas, Adolfo Soto-Domínguez

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Carbon nanotubes (CNTs) have emerged in recent years as a potential option for drug delivery, due to their high functionalization capacity. Biocompatibility and selectivity using tissue-specific biomolecules can optimize the specificity, pharmacokinetics and stability of the drug. In this study, we design, develop and characterize a drug nanovector (oxCNTs-HA-CPT) conjugating oxidated multi-wall carbon nanotubes (oxCNTs) with hyaluronate (HA) and carboplatin (CPT) as a treatment in a lung cancer model in vitro. Subsequently, we exposed TC–1 and NIH/3T3 cell lines to the nanovectors and measured cell uptake, cell viability, and oxidative stress induction. The characterization of oxCNTs-HA-CPT reveals that on their surface, they have HA. On the other hand, oxCNTs-HA-CPT were endocytosed in greater proportion by tumor cells than by fibroblasts, and likewise, the cytotoxic effect was significantly higher in tumor cells. These results show the therapeutic potential that nanovectors possess; however, future studies should be carried out to determine the death pathways involved, as well as their effect on in vivo models.