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Whole Grain Consumption For The Prevention And Treatment Of Breast Cancer

Mingsi Xie, Jie Liu, Rong Tsao, Ziyuan Wang, Baoguo Sun, Jing Wang
Published 2019 · Medicine
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Breast cancer is one of the most common and malignant cancers among females worldwide. Several epidemiological studies have indicated the inverse correlation between the intake of whole grains and the incidence of breast cancer. Whole grains are the most fundamental and important food source of bioactive phytochemicals, which have well-defined roles in the management of each stage of breast carcinogenesis. To better understand the value of whole grains in future prevention and treatment of breast cancer, the effects and possible mechanisms of six different whole grain cereals, which are the most commonly consumed throughout the world, are introduced in the current review. Moreover, the bioactive compounds extracted from whole grains are adequately formulated and the underlying mechanism of action is illustrated. In addition, the present limitations and future perspective of whole grain consumption for breast cancer are also concluded. The objective of this review is to promote the development of nutraceutical and functional food from whole grains and its application for reducing the risk of breast cancer.
This paper references
10.3945/ajcn.116.133496
Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and risk of type 2 diabetes in Scandinavian men and women.
Izabela Biskup (2016)
10.1016/j.phytochem.2004.04.001
Sorghum phytochemicals and their potential impact on human health.
Joseph M Awika (2004)
10.1371/journal.pone.0131377
Systematic Review and Meta-Analysis of Human Studies to Support a Quantitative Recommendation for Whole Grain Intake in Relation to Type 2 Diabetes
Aurélie Chanson-Rollé (2015)
10.1016/J.JFF.2013.02.004
Millet grain phenolics and their role in disease risk reduction and health promotion: A review
Fereidoon Shahidi (2013)
10.1007/s12272-014-0478-2
Chemical constituents of Triticum aestivum and their effects on adipogenic differentiation of 3T3-L1 preadipocytes
Bui Thi Thuy Luyen (2015)
10.3322/caac.21442
Cancer statistics, 2018.
Rebecca L Siegel (2018)
10.1016/J.COFS.2016.02.002
Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects
Hua Zhang (2016)
10.1093/jnci/djt352
Plasma Alkylresorcinols, Biomarkers of Whole-Grain Wheat and Rye Intake, and Incidence of Colorectal Cancer
Cecilie Kyrø (2014)
10.1053/j.gastro.2014.12.035
Nutrients, foods, and colorectal cancer prevention.
Mingyang Song (2015)
10.1021/tx200378c
Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.
Shabana I Khan (2012)
10.1097/01.ogx.0000201966.23445.91
Effect of screening and adjuvant therapy on mortality from breast cancer.
Donald A. Berry (2005)
10.1038/nature10983
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Christina Curtis (2012)
10.1016/j.jprot.2014.03.044
Preventive and therapeutic potential of peptides from cereals against cancer.
Margarita Ortíz-Martínez (2014)
10.1021/acs.jafc.8b02911
Identification, Quantification, and Anti-inflammatory Activity of 5- n-Alkylresorcinols from 21 Different Wheat Varieties.
Jie Liu (2018)
10.3322/caac.21338
Cancer statistics in China, 2015.
Wanqing Chen (2016)
10.1111/j.1753-4887.2010.00319.x
Dietary lignans: physiology and potential for cardiovascular disease risk reduction.
Julia J. Peterson (2010)
10.3390/nu9070728
Dietary Natural Products for Prevention and Treatment of Breast Cancer
Ya Li (2017)
10.1016/S1470-2045(06)70911-1
Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis.
Gillian K. Reeves (2006)
10.1016/j.pathol.2016.10.012
Molecular classification of breast cancer: what the pathologist needs to know.
Emad A. Rakha (2017)
10.1186/s12937-015-0059-3
Potential protective properties of flax lignan secoisolariciresinol diglucoside
Muhammad Imran (2015)
10.1093/nutrit/nuw003
Consumption of whole grains and cereal fiber in relation to cancer risk: a systematic review of longitudinal studies.
Nour Makarem (2016)
The effect of dietary fiber and other factors on insulin response: role in obesity.
Irma H. Ullrich (1985)
10.7150/jca.18457
Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping
Xiaofeng Dai (2017)
10.1080/01635581.2013.802001
Triticuside A, a Dietary Flavonoid, Inhibits Proliferation of Human Breast Cancer Cells Via Inducing Apoptosis
Y. H. Shan (2013)
10.1016/j.lfs.2013.01.006
The antiproliferative activity of 3-deoxyanthocyanins extracted from red sorghum (Sorghum bicolor) bran through P(53)-dependent and Bcl-2 gene expression in breast cancer cell line.
P. Suganyadevi (2013)
10.1021/bk-2011-1089.ch009
Sorghum Flavonoids: Unusual Compounds with Promising Implications for Health
Joseph M Awika (2011)
10.1007/978-3-319-59180-3_19
Dietary Patterns, Whole Plant Foods, Nutrients and Phytochemicals in Colorectal Cancer Prevention and Management
Mark L. Dreher (2018)
10.1079/PNS2002229
Rye, lignans and human health.
Göran Hallmans (2003)
10.1016/S1470-2045(13)70567-9
Breast cancer in China.
Lei Fan (2014)
10.1093/jn/130.4.767
Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner.
Maarit Hallikainen (2000)
10.1021/jf062516t
Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings.
Chun-Hat Shih (2007)
10.1016/j.ijbiomac.2015.05.035
Anticancer properties of low molecular weight oat beta-glucan – An in vitro study.
Anna Choromanska (2015)
10.1093/jnci/djn123
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy.
X-b Li (2008)
10.1016/J.FSHW.2016.05.004
Review of Finger millet (Eleusine coracana (L.) Gaertn): A power house of health benefiting nutrients
Dinesh Chandra (2016)
The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumors
(2012)
Modified Arabinoxylan from Rice Bran
M Ghoneum
10.1515/BC.2006.133
Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS
Hellinida Thomadaki (2006)
10.1016/J.JCS.2014.01.003
Recent findings on certain bioactive components in whole grain wheat and rye
Annica A.M. Andersson (2014)
10.1007/s10549-016-3910-0
Lifetime grain consumption and breast cancer risk
Maryam S Farvid (2016)
10.1248/bpb.b14-00719
Proanthocyanidin in red rice inhibits MDA-MB-231 breast cancer cell invasion via the expression control of invasive proteins.
Komsak Pintha (2015)
10.1016/j.bbrc.2014.09.126
Synergistic inhibition of cancer cell proliferation with a combination of δ-tocotrienol and ferulic acid.
Takahiro Eitsuka (2014)
10.1016/j.bmc.2011.05.025
5-alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth.
Yingdong Zhu (2011)
The effect of dietary fiber and other factors on insulin response: role in obesity
Ullrich Ih (1985)
10.1079/PNS2002232
Whole grain consumption and weight gain: a review of the epidemiological evidence, potential mechanisms and opportunities for future research.
Pauline Koh-Banerjee (2003)
10.1038/nrm3758
Molecular mechanisms of epithelial–mesenchymal transition
Samy Lamouille (2014)
10.3322/caac.21492
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray (2018)
Whole Plant Foods, Nutrients and Phytochemicals in Breast Cancer Prevention and Management
M L Dreher (2018)
10.1177/1534735415620010
Consumption of Whole Grains, Refined Cereals, and Legumes and Its Association With Colorectal Cancer Among Jordanians
Reema F Tayyem (2016)
10.1016/j.ctrv.2011.11.005
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
Pilar Eroles (2012)
Functional food-related bioactive compounds: effect of sorghum phenolics on cancer cells in vivo and conversion of short- to long-chain omega-3 polyunsaturated fatty acids in duck liver in vivo
Xi Chen (2017)
10.6026/97320630003326
Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes
Jyoti Upadhyay (2009)
10.1080/07315724.2014.963899
Whole Grain Consumption and Breast Cancer: A Case-Control Study in Women
Niki Mourouti (2016)
10.1016/J.JFF.2014.11.022
Aqueous extracts of hulled barley containing coumaric acid and ferulic acid inhibit adipogenesis in vitro and obesity in vivo
Cho-Rong Seo (2015)
10.1177/1534735417740630
Baker’s Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro
Nariman K. Badr El-Din (2018)
10.1016/j.intimp.2006.08.011
Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer.
Gokhan Demir (2007)
10.1017/S0007114513004388
Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Cecilie Kyrø (2014)
10.7314/APJCP.2015.16.10.4185
Dietary resistant starch contained foods and breast cancer risk: a case-control study in northwest of Iran.
Aynaz Tajaddini (2015)
10.7314/APJCP.2014.15.11.4601
Anti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.).
Komsak Pintha (2014)
10.1002/mnfr.201600852
Phytochemicals in whole grain wheat and their health‐promoting effects
Shengmin Sang (2017)
10.1155/2015/414250
Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway
Xiang-Yan Chen (2015)
10.1080/10408398.2014.887057
Sorghum (Sorghum bicolor L.): Nutrients, bioactive compounds, and potential impact on human health
Leandro de Morais Cardoso (2017)
10.1016/j.peptides.2010.05.018
Human cancer cell proliferation inhibition by a pentapeptide isolated and characterized from rice bran
Arvind Kannan (2010)
10.1038/nrd1902
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Bryan T. J. Hennessy (2005)
10.3322/caac.21565
Cancer treatment and survivorship statistics, 2019.
Kimberly D Miller (2019)
10.1002/9781119130765
Millets and Sorghum: Biology and Genetic Improvement
Jaywant Vilasrao Patil (2017)
10.1016/J.JFF.2013.09.004
An update on alkylresorcinols – Occurrence, bioavailability, bioactivity and utility as biomarkers
Rikard Landberg (2014)
10.1016/J.JCS.2007.06.010
Whole grain phytochemicals and health
Rui Hai Liu (2007)
10.1007/s00253-012-4279-6
Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells
Chui Ying Lee (2012)
10.1080/01635581.2018.1470647
Associations of Whole and Refined Grain Intakes with Adiposity-Related Cancer Risk in the Framingham Offspring Cohort (1991–2013)
Nour Makarem (2018)
10.1159/000315676
Targeted Therapy in Breast Cancer
Andreas Schneeweiss (2010)
10.1177/1934578X1200700820
Two New Alkylresorcinols from Homalomena wendlandii and Their Cytotoxic Activity
Luis Alberto Sánchez (2012)
10.1017/S0007114514002268
Epidemiological studies of oats consumption and risk of cancer and overall mortality.
Paolo Boffetta (2014)
10.1016/j.cell.2018.03.022
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
Katherine A. Hoadley (2018)
10.3978/j.issn.2072-1439.2015.05.15
Female breast cancer incidence and mortality in 2011, China.
Manman Jia (2015)
10.1158/1538-7445.TUMMET15-A13
Abstract A13: Macrophage FLT1 mediated inflammatory response determines breast cancer distal metastasis
Bin-Zhi Qian (2016)
10.1016/j.suronc.2009.01.004
Breast cancer chemoresistance: emerging importance of cancer stem cells.
Suebwong Chuthapisith (2010)
10.1016/j.jfda.2016.08.002
Bioactive phytochemicals in barley.
Emmanuel Idehen (2017)
10.1016/j.breast.2017.05.013
The emerging world of breast cancer immunotherapy.
Mark R Nathan (2018)
10.1093/annonc/mdr589
Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies.
Dagfinn Aune (2012)
10.1016/J.FOODCHEM.2011.07.023
Wheat bran lipophilic compounds with in vitro anticancer effects
Lei Liu (2012)
10.1371/journal.pbio.1000121
Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling
Hasan Korkaya (2009)
10.3945/ajcn.111.015578
Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies.
Jia-Yi Dong (2011)
10.3945/ajcn.115.122432
Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies.
Guo-Chong Chen (2016)
10.1094/CCHEM-04-16-0102-N
In Vitro Study on Effect of Germinated Wheat on Human Breast Cancer Cells
Kyongshin Cho (2016)
10.1016/J.JFF.2015.01.001
Bioactive phytochemicals in wheat: Extraction, analysis, processing, and functional properties
Devanand L. Luthria (2015)
10.1038/nature11412
Comprehensive molecular portraits of human breast tumors
Daniel C. Koboldt (2012)
10.1016/j.appet.2016.08.002
Effects on satiation, satiety and food intake of wholegrain and refined grain pasta
Iolanda Cioffi (2016)
10.3390/nu8090581
The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms
Ahmed Abdal Dayem (2016)
10.7314/APJCP.2014.15.15.6219
Anti-metastasis activity of black rice anthocyanins against breast cancer: analyses using an ErbB2 positive breast cancer cell line and tumoral xenograft model.
Liping Luo (2014)
10.1017/S0954422410000041
New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?
Anthony Fardet (2010)
10.1002/(SICI)1097-0215(19970529)71:5<800::AID-IJC18>3.0.CO;2-B
Family history and the risk of breast cancer: a systematic review and meta-analysis.
Paul D. P. Pharoah (1997)
10.1101/cshperspect.a003293
Systems biology and genomics of breast cancer.
Charles M. Perou (2011)
10.1186/s12935-017-0464-0
Avenanthramide-C reduces the viability of MDA-MB-231 breast cancer cells through an apoptotic mechanism
J. P. Hastings (2017)
10.4061/2011/891481
Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)
P. Suganya Devi (2011)
10.1016/j.bbrc.2014.09.069
Breast cancer stem cells, EMT and therapeutic targets.
Srishti Kotiyal (2014)
10.1186/bcr970
Radiation and breast cancer: a review of current evidence
Cécile M. Ronckers (2004)
10.1093/ajcn/77.3.622
Whole-grain and fiber intake and the incidence of type 2 diabetes.
Jukka Montonen (2003)
10.1080/09540105.2016.1148664
Effects of oat soluble and insoluble β-glucan on 1,2-dimethylhydrazine-induced early colon carcinogenesis in mice
Rui-Ling Shen (2016)
Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro.
Mamdooh H Ghoneum (2014)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
10.1371/journal.pone.0040531
Hwanggeumchal sorghum Induces Cell Cycle Arrest, and Suppresses Tumor Growth and Metastasis through Jak2/STAT Pathways in Breast Cancer Xenografts
Jin Hee Park (2012)
10.1016/j.bbrc.2011.01.065
Dihydroavenanthramide D inhibits human breast cancer cell invasion through suppression of MMP-9 expression.
Young-Rae Lee (2011)
10.1002/mnfr.201100231
Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity.
Ulrika Andersson (2011)
10.1007/s00217-017-2890-6
Dietary alkylresorcinols and cancer prevention: a systematic review
Joanna Kruk (2017)
Molecular mechJournal of Food Researchanisms of epithelial-mesenchymal transition
S. Lamouille (2014)
10.1021/jf8035066
Sorghum 3-deoxyanthocyanins possess strong phase II enzyme inducer activity and cancer cell growth inhibition properties.
Liyi Yang (2009)
10.1038/s41467-018-03600-6
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
Melissa A Meyer (2018)
10.1038/ejcn.2017.149
Association of whole grain intake with all-cause, cardiovascular, and cancer mortality: a systematic review and dose–response meta-analysis from prospective cohort studies
Ben Zhang (2018)
10.1021/jf302872a
Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols.
Yingdong Zhu (2012)
10.1021/jf2023353
Antioxidant activity of alkylresorcinols from rye bran and their protective effects on cell viability of PC-12 AC cells.
Julia Gliwa (2011)
10.1158/1055-9965.EPI-15-0578
Global Cancer Incidence and Mortality Rates and Trends—An Update
Lindsey A. Torre (2015)
10.1016/j.mce.2013.06.003
The immune system and inflammation in breast cancer
Xinguo Jiang (2014)
Cancer treatment and survivorship statistics
K D Miller (2019)
10.3892/ijmm.2017.3183
Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling
Jie Zhou (2017)
10.1002/mnfr.201600715
Whole grain oats, more than just a fiber: Role of unique phytochemicals
Shengmin Sang (2017)
10.1186/s12937-018-0394-2
Association between whole grain intake and breast cancer risk: a systematic review and meta-analysis of observational studies
Yunjun Xiao (2018)
10.1080/10408398.2016.1229657
Natural antioxidant polyphenols on inflammation management: Anti-glycation activity vs metalloproteinases inhibition
Lucia Crascí (2018)
10.1016/j.foodchem.2014.09.089
Phenolic and carotenoid profiles and antiproliferative activity of foxtail millet.
Li Zhen Zhang (2015)
10.1007/bf03543695
The world wheat book: a history of wheat breeding.
Alain Bonjean (2001)
10.1001/jamaoncol.2017.3684
Fiber Intake and Survival After Colorectal Cancer Diagnosis
Mingyang Song (2018)
10.1016/S0960-9776(09)70274-7
Targeting breast cancer stem cells.
Max Wicha (2009)
10.1016/j.cell.2018.03.042
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data
Carolyn M. Hutter (2018)
10.1111/bph.13608
Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review.
Arrigo Francesco Giuseppe Cicero (2017)
10.1016/S1470-2045(18)30368-1
Breast cancer in a Renaissance Book of the Dead.
Emma Nicholls (2018)
10.1021/acs.jafc.5b06071
Steroidal Saponins in Oat Bran.
Jun-Li Yang (2016)
10.1542/peds.2015-1226
Dietary Fiber Intake in Young Adults and Breast Cancer Risk
Maryam S Farvid (2016)
10.1016/S0140-6736(11)61539-0
Gene expression profiling in breast cancer: classification, prognostication, and prediction
Jorge Sergio Reis-Filho (2011)
10.5539/JFR.V3N4P18
Role of Nutraceuticals in Cancer Therapy
Elia Ranzato (2014)
10.1080/10408390802248734
Health Benefits of Whole Grain Phytochemicals
Neal Okarter (2010)
10.1080/01635580701308083
Wheat Grass Juice May Improve Hematological Toxicity Related to Chemotherapy in Breast Cancer Patients: A Pilot Study
Gil Bar-Sela (2007)
NF-kappa B as a Critical Link Between Inflammation and Cancer
M. Karin (2009)
10.3390/foods5010005
Triticale Bran Alkylresorcinols Enhance Resistance to Oxidative Stress in Mice Fed a High-Fat Diet
Rania Agil (2016)
10.1017/S0007114514003249
Relationship between bread and obesity.
Luís Serra-Majem (2015)
10.2337/diacare.28.12.2978
Do glycemic index, glycemic load, and fiber play a role in insulin sensitivity, disposition index, and type 2 diabetes?
Xavier Pi-Sunyer (2005)
10.3322/caac.21442
Cancer statistics, 2018
Rebecca L. Siegel Mph (2018)
10.1371/journal.pone.0002888
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
A. Morel (2008)
10.1080/01635581.2016.1154577
Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro
Peter Kubatka (2016)
10.3945/jn.114.202754
Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice.
Katsutaka Oishi (2015)
10.1016/J.COFS.2017.01.004
Health benefits of oat: current evidence and molecular mechanisms
Cristina Martínez-Villaluenga (2017)
10.1089/jmf.2010.0143
Inhibition of aromatase and α-amylase by flavonoids and proanthocyanidins from Sorghum bicolor bran extracts.
James L. Hargrove (2011)
10.1016/j.cdp.2008.02.006
MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin.
Sastry Gollapudi (2008)



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