Online citations, reference lists, and bibliographies.
← Back to Search

Application Of Focus Variation Microscopy And Dissolution Imaging In Understanding The Behaviour Of Hydrophilic Matrices

Adam Ward, Benedict Brown, K. Walton, P. Timmins, B. Conway, K. Asare-Addo
Published 2020 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument. The auto correlation length (Sal) showed all surface profiles from the compacts displayed a value below 0.1 mm, indicating that only high frequency components (i.e., roughness) were considered and that the analysis had been successful. The developed interfacial area ratio (Sdr) displayed values below 5% in line with ISO guidelines for all the polymers studied with their texture aspect ratio values (Str) > 0.5, indicating uniformity of the surfaces of the produced compacts. Of the various parameters studied, areal material ratio (Smr2) predicted XG to wet and hydrate quicker than PEO, with PEO also wetting and hydrating quicker than the HPMC. The dissolution imaging and initial swelling studies proved to concur with the findings from the areal material ratio (Smr2) parameter, suggesting porosity was not an indicator for the ease with which water ingress occurs. This study suggests the Smr2 surface parameter to potentially predict wetting and initial hydration of hydrophilic polymers, however care should be taken as this study consists of a selected number of hydrophilic polymers.
This paper references
Real-Time UV Imaging of Nicotine Release from Transdermal Patch
Jesper Østergaard (2010)
Atlanta, GA, USA, 2008; pp
C. P. KELTROL®KELZAN®—Xanthan Gum Book 8th ed. Kelco (2020)
Measuring water distribution in extrudates using magnetic resonance imaging (MRI).
G. Tomer (1999)
The effect of dissolution on the surface texture of model solid-dosage forms as assessed by non-contact laser profilometry
A. M. Healy (1995)
The topographic development and areal parametric characterization of a stratified surface polished by mass finishing
K. Walton (2015)
Effect of preparation method on the surface properties and UV imaging of indomethacin solid dispersions
K. Asare-Addo (2019)
The influence of vitamin E succinate on the stability of polyethylene oxide PEO controlled release matrix tablets.
S. Shojaee (2013)
Diffusion of small molecular weight drugs in radiation-crosslinked poly(ethylene oxide) hydrogels
J. Stringer (1996)
A novel technique for the visualization of tablet punch surfaces: Characterization of surface modification, wear and sticking.
Claudia Al-Karawi (2017)
Surface Texture. Areal. Terms, Definitions and Surface Texture Parameters
Xanthan gum as a rate-controlling polymer for the development of alcohol resistant matrix tablets and mini-tablets.
A. Lazzari (2018)
Simultaneous In Vivo Visualization and Localization of Solid Oral Dosage Forms in the Rat Gastrointestinal Tract by Magnetic Resonance Imaging (MRI)
V. Christmann (2004)
Investigation of within-tablet dynamics for extended release of a poorly-soluble basic drug from hydrophilic matrix tablets using ATR-FTIR imaging.
Farah Deeba Zahoor (2020)
Application of terahertz pulsed imaging to analyse film coating characteristics of sustained-release coated pellets.
M. Haaser (2013)
Focus Variation – a Robust Technology for High Resolution Optical 3D Surface Metrology
R. Danzl (2011)
Direct imaging of the dissolution of salt forms of a carboxylic acid drug
K. Asare-Addo (2018)
Properties of sustained-release tablets prepared by hot-melt extrusion.
F. Zhang (1999)
Measurement of the Diffusion of 2,2,2-trifluoroacetamide Within Thermoresponsive Hydrogels Using NMR Imaging
R. Dinarvand (2004)
Microenvironmental pH modifying films for buccal delivery of saquinavir: effects of organic acids on pH and drug release in vitro.
Shaolong He (2020)
Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR Imaging
A. Rajabi-Siahboomi (2004)
Evaluation of High Molecular Weight Poly(Oxyethylene) (Polyox) Polymer: Studies of Flow Properties and Release Rates of Furosemide and Captopril from Controlled-Release Hard Gelatin Capsules
M. Efentakis (2000)
Microstructural imaging of early gel layer formation in HPMC matrices.
G. S. Bajwa (2006)
Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion.
M. M. Crowley (2002)
Design and development of a novel fused filament fabrication (FFF) 3D printed diffusion cell with UV imaging capabilities to characterise permeation in pharmaceutical formulations.
Zayeem Fazili (2020)
Areal parametric characterisation of ex-service compressor blade leading edges
K. Walton (2014)
Hydrophilic Matrix Tablets for Oral Controlled Release
P. Timmins (2014)
Drug release from compressed hydrophilic POLYOX-WSR tablets.
C. J. Kim (1995)
Comparative study on xanthan gum and hydroxypropylmethyl cellulose as matrices for controlled-release drug delivery I. Compaction and in vitro drug release behaviour
M. M. Talukdar (1996)
Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging
D. Markl (2018)
A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage
D. A. Alderman (1984)
An investigation into the use of low quantities of functional additives to control drug release from hot melt extruded solid dispersions for poorly soluble drug
F. Alqahtani (2020)
An investigation into the use of low quantities of functional additives to control drug release from hot melt extruded solid dispersions for poorly soluble drug delivery.
Fahad Al-Qahtani (2020)
High fidelity replication of surface texture and geometric form of a high aspect ratio aerodynamic test component
K. Walton (2016)
A discriminatory intrinsic dissolution study using UV area imaging analysis to gain additional insights into the dissolution behaviour of active pharmaceutical ingredients.
Wendy L. Hulse (2012)
An investigation of drug compact topography as relates to intrinsic dissolution rates determined by dissolution imaging
Benedict J. Brown (2020)
Magnetic Resonance Imaging and Image Analysis for Assessment of HPMC Matrix Tablets Structural Evolution in USP Apparatus 4
P. Kulinowski (2010)
International Standards Organisation. BS EN ISO 25178-2:2012: Geometrical Product Specifications (GPS)
A New Approach to Dissolution Testing by UV Imaging and Finite Element Simulations
J. Boetker (2013)
Behaviour of HPMC compacts investigated using UV-imaging.
J. Pajander (2012)
Development of a novel method utilising dissolution imaging for the measurement of swelling behaviour in hydrophilic matrices
Adam Ward (2019)
Interrogating erosion-based drug liberation phenomena from hydrophilic matrices using near infrared (NIR) spectroscopy.
Paolo Avalle (2013)
Diffusion and Swelling Measurements in Pharmaceutical Powder Compacts Using Terahertz Pulsed Imaging
Samy Yassin (2015)
A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging.
E. Kaunisto (2010)
The impact of polyelectrolyte structure on the shape of nanoassemblies with cationic peptides.
M. Ferstl (2013)
Imaging of the Effect of Alcohol-Containing Media on the Performance of Hypromellose Hydrophilic Matrix Tablets: Comparison of Direct Compression and Regular Grades of Polymer
Nihad Mawla (2020)
Advanced Techniques for Assessment Surface Topography: Development of a Basis for 3D Surface Texture Standards "Surfstand"
L. Blunt (2003)
A review of cellulose ethers in hydrophilic matrices for oral controlled - release dosage forms
D. A. Alderman (1984)
Investigating in vitro drug release mechanisms inside dosage forms. Monitoring liquid ingress in HPMC hydrophilic matrices using confocal microscopy.
C. Melia (1997)
Application of Poly(oxyethylene) Homopolymers in Sustained Release Solid Formulations
A. Moroni (1995)
The use of visible and UV dissolution imaging for the assessment of propranolol hydrochloride in liquisolid compacts of Sesamum radiatum gum
A. Ward (2020)
Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release.
A. Apicella (1993)
A Novel Nuclear Magnetic Resonance (NMR) Imaging Method for Measuring the Water Front Penetration Rate in Hydrophilic Polymer Matrix Capsule Plugs and Its Role in Drug Release
M. Ashraf (2004)
The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.
K. Asare-Addo (2013)
Advances in mechanistic understanding of release rate control mechanisms of extended-release hydrophilic matrix tablets.
P. Timmins (2016)
Rheological characterization of xanthan gum and hydroxypropylmethyl cellulose with respect to controlled-release drug delivery.
M. M. Talukdar (1996)
Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination.
A. Ward (2017)

Semantic Scholar Logo Some data provided by SemanticScholar