Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Role Of Nanoparticle–Polymer Interactions On The Development Of Double-Network Hydrogel Nanocomposites With High Mechanical Strength

A. Chang, Nasim Babhadiashar, Emma Barrett-Catton, Prashanth Asuri
Published 2020 · Materials Science, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Extensive experimental and theoretical research over the past several decades has pursued strategies to develop hydrogels with high mechanical strength. Our study investigated the effect of combining two approaches, addition of nanoparticles and crosslinking two different polymers (to create double-network hydrogels), on the mechanical properties of hydrogels. Our experimental analyses revealed that these orthogonal approaches may be combined to synthesize hydrogel composites with enhanced mechanical properties. However, the enhancement in double network hydrogel elastic modulus due to incorporation of nanoparticles is limited by the ability of the nanoparticles to strongly interact with the polymers in the network. Moreover, double-network hydrogel nanocomposites prepared using lower monomer concentrations showed higher enhancements in elastic moduli compared to those prepared using high monomer concentrations, thus indicating that the concentration of hydrogel monomers used for the preparation of the nanocomposites had a significant effect on the extent of nanoparticle-mediated enhancements. Collectively, these results demonstrate that the hypotheses previously developed to understand the role of nanoparticles on the mechanical properties of hydrogel nanocomposites may be extended to double-network hydrogel systems and guide the development of next-generation hydrogels with extraordinary mechanical properties through a combination of different approaches.
This paper references
Designing hydrogels for controlled drug delivery.
Jianyu Li (2016)
The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells.
Akhilesh Banerjee (2009)
Effects of silica sol content on the properties of poly(acrylamide)/silica composite hydrogel
L. Wu (2011)
Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites
J. Zaragoza (2018)
Synthesis and characterization of poly(sodium acrylate)/ bentonite superabsorbent composite
Y. Xie (2012)
Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach?
B. Willie (2010)
Thermoresponsive polysaccharides and their thermoreversible physical hydrogel networks.
S. Graham (2019)
Hydrogel as a bioactive material to regulate stem cell fate
Yung-Hao Tsou (2016)
Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite Hydrogels
J. Zaragoza (2015)
Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior
C. Dannert (2019)
The Use of Chitosan, Alginate, and Pectin in the Biomedical and Food Sector—Biocompatibility, Bioadhesiveness, and Biodegradability
Gheorghe Adrian Martău (2019)
Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration.
Solitaire A. DeLong (2005)
Synergistic toughening of nanocomposite double network hydrogels by physical adsorption and chemical bonding of polymer chains to inorganic nanospheres and nanorods: a comparative study
Guorong Gao (2016)
Double network hydrogel of sodium alginate/polyacrylamide cross-linked with POSS: Swelling, dye removal and mechanical properties.
Zahra Bahrami (2019)
Hydrogels for Soft Machines
P. Calvert (2009)
A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration
Mark-Phillip Pebworth (2014)
Super-tough double-network hydrogels reinforced by covalently compositing with silica-nanoparticles
Q. Wang (2012)
Simultaneous Enhancement of Stiffness and Toughness in Hybrid Double-Network Hydrogels via the First, Physically Linked Network
Qiang Chen (2015)
Biomedical applications of hydrogels: A review of patents and commercial products
Enrica Caló (2015)
Double network hydrogel for tissue engineering.
Zhipeng Gu (2018)
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.
Nasim Annabi (2014)
Enzyme-Functionalized Piezoresistive Hydrogel Biosensors for the Detection of Urea
J. Erfkamp (2019)
A mechanically robust double-network hydrogel with high thermal responses via doping hydroxylated boron nitride nanosheets
Lu Xing (2018)
Effect of carbon nanotubes reinforcement on the polyvinyl alcohol – polyethylene glycol double-network hydrogel composites: A general approach to shape memory and printability
H. Nurly (2019)
Alginate: properties and biomedical applications.
K. Lee (2012)
Effect of particle concentration on the microstructural and macromechanical properties of biocompatible magnetic hydrogels.
A. B. Bonhome-Espinosa (2017)
Hydrogel Modulus Affects Proliferation Rate and Pluripotency of Human Mesenchymal Stem Cells Grown in Three-Dimensional Culture.
Revital Goldshmid (2017)
Characterization of the interfacial interaction between polyacrylamide and silicon substrate by Fourier transform infrared spectroscopy
Xiaolin Lu (2005)
Hydrogel Based Sensors for Biomedical Applications: An Updated Review
J. Tavakoli (2017)
Why are double network hydrogels so tough
J. Gong (2010)
Effect of crosslinker length on the elastic and compression modulus of poly(acrylamide) nanocomposite hydrogels
J. Zaragoza (2017)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar