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Phytochemical Molluscicides And Schistosomiasis: What We Know And What We Still Need To Learn

Ronaldo de Carvalho Augusto, Clélia Christina Corrêa de Mello-Silva
Published 2018 · Biology

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Worldwide schistosomiasis remains a serious public health problem with approximately 67 million people infected and 200 million at risk of infection from inhabiting or transiting endemically active regions. Africa, South America, the Caribbean, and the Middle East are the main transmission regions of Schistosoma mansoni. The fight against transmission through the use of molluscicides is not recent and has been advocated as the only activity with the possibility of interruption of transmission in small, epidemiologically active outbreaks. Euphorbia milii var. hislopii (syn. splendens) (Des Moulins, 1826) is the most promising for use in official schistosomiasis control programs according to the WHO. In this review, we show that an understanding of some how E. milii latex affects the snail vector and their parasites from a molecular level to field conditions is lacking. On the other hand, this type of treatment could also provide a rationale for the control of schistosomiasis and other parasitosis. Several publications contribute to enforcing the use of E. milii latex in endemic countries as a cheap alternative or complement to mass drug treatment with praziquantel, the only available drug to cure the patients (without preventing re-infection).
This paper references
10.1017/S0031182014000870
Resistance to niclosamide in Oncomelania hupensis, the intermediate host of Schistosoma japonicum: should we be worried?
Jian-rong Dai (2015)
10.1016/j.vetpar.2010.04.037
Bioactivity of latex from Euphorbia splendens var. hislopii (Euphorbiaceae) on post-embryonic development of Megaselia scalaris (Phoridae).
Renata da Silva Mello (2010)
10.4236/OJVM.2015.56017
Schistosoma mansoni: Phytochemical Effect on Aquatic Life Cycle
Ronaldo de Carvalho Augusto (2015)
10.1186/1478-4505-9-3
Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda
Melissa Parker (2011)
10.1016/0378-8741(90)90040-Z
Topical antiinflammatory effects of Euphorbia prostrata on carrageenan-induced footpad oedema in mice.
A. Singla (1990)
10.1021/cr078350s
Chemical and pharmacological research of the plants in genus Euphorbia.
Q. Shi (2008)
10.5897/AJPAC2018.0749
Isolation and characterisation of chemical compounds from the plants, Phytolacca octandra (L.), Phytolacca dodecandra (LHerit) and Balanites aegyptiaca (L.) commonly used to control schistosomiasis transmitting snails in Kenya
S. T. Kariuki (2018)
10.1098/rstb.2012.0144
Preventive chemotherapy as a strategy for elimination of neglected tropical parasitic diseases: endgame challenges
M. Bockarie (2013)
10.1016/j.actatropica.2010.10.007
The influence of exposure to Euphorbia splendens var. hislopii latex on the concentrations of total proteins and nitrogen products in Biomphalaria glabrata infected with Schistosoma mansoni.
Clélia Christina Mello-Silva (2011)
10.1046/J.1365-3156.2001.00811.X
Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence.
B. Gryseels (2001)
10.1590/S0074-02761991000600021
Toxicological study of the molluscicidal latex of Euphorbia splendens: irritant action on skin and eye.
J. C. Freitas (1991)
10.1076/PHBI.36.5.357.4656
ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANTS FROM THE PHILIPPINES
L. G. Lirio (1998)
10.1006/EESA.2000.1924
Toxicity of Euphorbia milii latex and niclosamide to snails and nontarget aquatic species.
E. C. Oliveira-Filho (2000)
10.1590/S0100-879X1997001100011
Study of the embryofeto-toxicity of Crown-of-Thorns (Euphorbia milii) latex, a natural molluscicide.
C. A. Souza (1997)
10.1371/journal.pntd.0004290
Systematic Review and Meta-analysis of the Impact of Chemical-Based Mollusciciding for Control of Schistosoma mansoni and S. haematobium Transmission
C. King (2015)
10.3923/AJE.2010.123.140
Strategic control of schistosome intermediate host.
Manal A. Hamed (2010)
10.1134/S1021443708040201
New strategy for the search of natural biologically active substances
V. Dushenkov (2008)
10.2307/2992104
Phytochemistry and systematics of the Euphorbiaceae
D. Seigler (1994)
10.1002/jat.1498
Molluscicides from some common medicinal plants of eastern Uttar Pradesh, India.
S. Singh (2010)
10.1590/S0074-02762011000200006
Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails.
F. B. Couto (2011)
10.1590/S0074-02762001000100014
The molluscicidal activity of the latex of Euphorbia splendens var. hislopii on Melanoides tuberculata (Thiaridae), a snail associated with habitats of Biomphalaria glabrata (Planorbidae).
A. Giovanelli (2001)
10.1139/Z03-220
Genome and genomics of schistosomes
G. Oliveira (2004)
10.1016/S0031-9422(00)90515-6
Investigation of the diurnal, ontogenetic and seasonal variation in the molluscicidal saponin content of Phytolacca dodecandra aqueous berry extracts.
J. Ndamba (1993)
10.1016/j.phytochem.2010.02.009
Purification and biochemical characterization of Eumiliin from Euphorbia milii var. hislopii latex.
K. C. B. Fonseca (2010)
10.1590/S0074-02761998000700042
Effects of Euphorbia milii latex on Schistosoma mansoni eggs, miracidia and cercariae.
R. R. De-Carvalho (1998)
10.1016/0273-2300(91)90006-H
Endod: safety evaluation of a plant molluscicide.
J. D. Lambert (1991)
10.1590/S0074-02761989000500008
Plantas empregadas como moluscicidas: uma visão crítica
P. Jurberg (1989)
10.1081/CLT-100100920
Hepatotoxicity from Castor Bean Ingestion in a Child
W. Palatnick (2000)
10.1055/s-2007-969973
On the Active Principles of the Euphorbiaceae
A. Marston (1983)
10.1590/S0074-02761997000500029
Evaluation of the molluscicidal properties of Euphorbia splendens var. hislopii (N.E.B.) latex: experimental test in an endemic area in the State of Minas Gerais, Brazil.
N. Mendes (1997)
Evaluation of some plant latices against Heterodera cajani on cowpea (Vigna sinensis).
L. Devi (2000)
10.1016/S0001-706X(01)00126-7
The control of the schistosome-transmitting snail Biomphalaria glabrata by the plant Molluscicide Euphorbia splendens var. hislopii (syn milli Des. Moul): a longitudinal field study in an endemic area in Brazil.
V. Schall (2001)
10.1016/0035-9203(79)90157-3
Seasonal patterns in the transmission of Schistosoma haematobium in Rhodesia, and its control by winter application of molluscicide.
C. Shiff (1979)
10.1016/J.PT.2005.01.001
Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach?
N. R. Bergquist (2005)
10.1016/j.jare.2012.07.003
Epidemiology of Schistosomiasis in Egypt: Travel through Time: Review
R. Barakat (2013)
10.1016/S0378-4274(03)00303-5
Absence of tumor promoting activity of Euphorbia milii latex on the mouse back skin.
I. Delgado (2003)
10.1590/S0074-02762006000100002
Physiological changes in Biomphalaria glabrata Say, 1818 (Pulmonata: Planorbidae) caused by sub-lethal concentrations of the latex of Euphorbia splendens var. hislopii N.E.B (Euphorbiaceae).
C. C. Mello-Silva (2006)
10.1016/S0031-9422(00)90788-X
Molluscicidal milliamines from Euphorbia milii var. hislopii
C. L. Zani (1993)
10.1371/journal.pntd.0003853
The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection
D. Roquis (2015)
10.1590/S1516-89132003000300013
Molluscicidal activity of crown of Christ (Euphorbia splendens var. hislopii) (Euphorbiaceae) latex submitted to pH variation
M. Vasconcellos (2003)
Laboratory and field evaluation of the molluscicidal properties of Phytolacca dodecandra.
A. Lemma (1970)
10.1371/journal.pntd.0005789
Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites
R. D. C. Augusto (2017)
10.1021/np50034a023
Correlation of the anticholinesterase and molluscicidal activity of the latex of Euphorbia royleana on the snail Lymnaea acuminata.
D. Singh (1984)
10.1007/PL00000881
Revisiting the enzymes stored in the laticifers of Carica papaya in the context of their possible participation in the plant defence mechanism
A. El Moussaoui (2001)
10.1172/JCI34261
Helminth infections: the great neglected tropical diseases.
P. Hotez (2008)
Alterações nos depósitos de glicogênio e conteúdo de glicose nahemolinfa de Achatina fulica bowdich, 1822 (mollusca, gastropoda), hospedeirointermediário de Angiostrongylus, exposta ao látex de coroa de cristo Euphorbia splendensvar. hislopii.
C. S. Oliveira (2007)
10.1590/S0074-02762003000400025
Molluscicidal action of the latex of Euphorbia splendens var. hislopii N.E.B. ("Christ's Crown") (Euphorbiaceae) against Lymnaea columella (Say, 1817) (Pulmonata: Lymnaeidae), intermediate host of Fasciola hepatica Linnaeus, 1758 (Trematode: Fasciolidae): 1- test in laboratory.
M. Vasconcellos (2003)
10.1371/journal.pntd.0005812
Why reinvent the wheel? Lessons in schistosomiasis control from the past
Clive J Shiff (2017)
10.1590/S0074-02762010000400024
Carbohydrate metabolism alterations in Biomphalaria glabrata infected with Schistosoma mansoni and exposed to Euphorbia splendens var. hislopii latex.
Clélia Christina Mello-Silva (2010)
10.1136/bmj.319.7222.1423
The value of DALY life: problems with ethics and validity of disability adjusted life years
T. Arnesen (1999)
10.1590/S0074-02761986000400017
Latex of "coroa de cristo" (Euphorbia splendens): an effective molluscicide.
M. C. de Vasconcellos (1986)
10.2174/1389557511313040003
The evolution of drugs on schistosoma treatment: looking to the past to improve the future.
M. G. da Rocha Pitta (2013)
10.1017/S0031182013000231
New approaches for understanding mechanisms of drug resistance in schistosomes.
R. Greenberg (2013)



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