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Effect Of Diabetes Mellitus On Outcomes Of Colorectal Cancer

Geum Youb Noh, Dae-Yong Hwang, Yoon Hee Choi, Yun Yong Lee
Published 2010 · Medicine
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Purpose Many studies have revealed that diabetes mellitus (DM) increases a person's lifetime risk of colorectal cancer and that DM is associated with a worse outcome of colon cancer, but this association is controversial. In this study, we intended to examine the relationship between DM and the long-term outcomes of colorectal cancer. Methods A retrospective analysis was conducted on 657 patients who underwent surgery due to colorectal cancer between 1997 and 2004 at Korea Cancer Center Hospital. The operations were done by a single surgeon. With a median follow-up of 4.7 years, we analyzed differences in recurrence-free survival (RFS) and overall survival (OS) between patients with DM and those without DM. Results Of the 657 patients, 374 (57%) were males and 67 (10%) had DM. There was no difference in age at diagnosis, sex and pathologic stage of colorectal cancer according to the presence of DM. There were no difference in the RFS and the OS of colon cancer between the patients with DM and those without DM. At 5 years, the RFS was 71.3% in diabetic patients vs. 70.4% in non-diabetic patients (P = 0.480), and the OS was 68.8% in diabetic patients vs. 75.0% in non-diabetic patients (P = 0.498). There was no difference in the median survival between the groups (9.6 years in the diabetic group vs. 10.6 years in the non-diabetic group; P = 0.495). Conclusion In this study, we did not find any relation between the presence of DM and either the recurrence or the survival in cases of colorectal cancer. More studies to elucidate whether the influence of DM is directly related to a higher rate of cancer recurrence or survival are needed.
This paper references
Cancer Lett
Cancer Yps Or (1988)
10.1007/s10620-009-0944-8
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
Prevalence and management status of diabetes mellitus in Korea. Korean
S A Kim (2005)
10.5124/jkma.2008.51.9.791
The Present State of Diabetes Mellitus in Korea
Sin Gon Kim (2008)
Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study.
Kay-Tee Khaw (2004)
10.1093/oxfordjournals.aje.a009534
Colorectal cancer: another complication of diabetes mellitus?
J. C. Ogilvie Will (1998)
Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic pol- Journal of The Korean Society of Coloproctology www
J Stadler
10.1016/0304-3835(88)90023-7
Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer.
J. Stadler (1988)
10.1007/s00125-006-0468-0
Diabetes mellitus and risk of bladder cancer: a meta-analysis
Susanna C. Larsson (2006)
10.1093/aje/kwh161
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults.
Steven Scott Coughlin (2004)
10.1385/MO:23:4:515
Effect of diabetes mellitus on the epidemiology and outcomes of colon cancer
Nicole A Shonka (2006)
10.1038/sj.bjc.6602619
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
R Huxley (2005)
10.1111/j.1442-2042.2007.01744.x
Diabetes mellitus and kidney cancer risk: the results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).
Masakazu Washio (2007)
10.1002/ijc.23192
Chronic inflammation and oxidative stress in human carcinogenesis.
Alessandro Federico (2007)
Prevalence Of Diabetes And Management Status In Korean Population
Nam Han Cho (2005)
10.1002/ijc.22717
Diabetes mellitus and risk of breast cancer: a meta-analysis.
Susanna C. Larsson (2007)
10.7326/0003-4819-122-5-199503010-00002
Physical Activity, Obesity, and Risk for Colon Cancer and Adenoma in Men
Edward L. Giovannucci (1995)
10.1016/j.cgh.2005.12.007
The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence.
Hashem B. El-Serag (2006)
10.1136/gut.2005.073163
Influence of obesity on the risk of developing colon cancer
Ermenegildo Eldo Frezza (2006)
10.1001/jama.293.2.194
Fasting serum glucose level and cancer risk in Korean men and women.
Sun Ha Jee (2005)
Prevalence and management status of diabetes mellitus in Korea
Sang A. Kim (2005)
Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study. 1988.
Gabriel A. Kune (2007)
10.1093/ije/dym193
Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study.
Gabriel A. Kune (1988)
10.1200/JCO.2003.07.125
Impact of diabetes mellitus on outcomes in patients with colon cancer.
Jeffrey A. Meyerhardt (2003)
10.1093/jnci/dji375
Diabetes mellitus and risk of colorectal cancer: a meta-analysis.
Susanna C. Larsson (2005)
10.1007/s00125-007-0681-5
Diabetes mellitus and risk of endometrial cancer: a meta-analysis
Ebba Friberg (2007)



This paper is referenced by
10.18632/oncotarget.19923
Increased mortality for colorectal cancer patients with preexisting diabetes mellitus: an updated meta-analysis
Jingtao Li (2017)
10.1371/journal.pone.0055196
Impact of Diabetes on Oncologic Outcome of Colorectal Cancer Patients: Colon vs. Rectal Cancer
Justin Y. Jeon (2013)
10.1634/theoncologist.2013-0423
Type 2 diabetes mellitus is associated with increased mortality in Chinese patients receiving curative surgery for colon cancer.
K.-H. Chen (2014)
10.4143/crt.2014.46.3.288
Impact of Hyperglycemia on Survival and Infection-Related Adverse Events in Patients with Metastatic Colorectal Cancer Who Were Receiving Palliative Chemotherapy
Yong Joo Hong (2014)
10.1097/MD.0000000000005941
Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran
Mohammad Aziz Rasouli (2017)
CMAR_A_233215 451..459
Nahla Ali Azzam (2020)
10.1007/s00384-020-03666-z
Diabetes mellitus and colorectal carcinoma outcomes: a meta-analysis
Daniel J. Becker (2020)
10.1007/s13668-012-0034-y
The Role of Diabetes and Diabetes Treatments in Colorectal Cancer Mortality, Incidence, and Survival
Peter T. Campbell (2012)
Colorectal cancer survival in Jordan 2003-2007
Mohannad Al Nsour (2014)
10.1016/j.urolonc.2011.12.013
Pre-existing type-2 diabetes is not an adverse prognostic factor in patients with renal cell carcinoma: a single-center retrospective study.
Alessandro Antonelli (2013)
10.1016/j.diabres.2016.12.009
Optimal glycemic target level for colon cancer patients with diabetes.
Shin Jun Lee (2017)
10.1186/1477-7819-10-76
The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer
Ching-Wen Huang (2012)
Type 2 Diabetes Mellitus and Colorectal Cancer Risk and Survival in Oman
Rose Ngozi Mafiana (2017)
10.4155/fsoa-2018-0044
Survival and glycemic control in patients with colorectal cancer and diabetes mellitus
Nina J. Karlin (2018)
10.1089/dna.2013.2161
High glucose modulates antiproliferative effect and cytotoxicity of 5-fluorouracil in human colon cancer cells.
Yi-Shing Ma (2014)
10.1097/DCR.0b013e3182a479f9
Diabetes Mellitus and Colorectal Cancer Prognosis: A Meta-analysis
Katherine T. Mills (2013)
10.1371/journal.pone.0176068
The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies
Bo Zhu (2017)
10.3892/etm.2018.6189
High glucose induces epithelial-mesenchymal transition and results in the migration and invasion of colorectal cancer cells
Jiayan Wu (2018)
10.1038/bjc.2014.68
Diabetes and prognosis in older persons with colorectal cancer
Juhua Luo (2014)
10.2147/CMAR.S233215
Predictors of Survival Among Colorectal Cancer Patients in a Low Incidence Area
Nahla Ali Azzam (2020)
10.1155/2012/768247
The Association between Obesity and Colorectal Cancer
Kevin A. Whitlock (2012)
10.1007/s10552-018-1083-3
Risk of colon cancer recurrence in relation to diabetes
Jessica Chubak (2018)
10.4103/0019-509X.134593
Socio-demographic characteristics of cancer patients: hospital based cancer registry in a tertiary care hospital of India.
Sushmita Puri (2014)
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