Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Spray-dried Ketoprofen Lysine-incorporated PLGA Nanoparticles; Formulation, Characterization, Evaluation And Cytotoxic Profile

Akin Elmaskaya, A. A. Öztürk, G. Büyükköroğlu, E. Yenilmez
Published 2019 · Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Ketoprofen lysine because of a short half-life (1-2 h) multiple dosing regimens are required for oral administration. For this reason, this study is concerned with the preparation of poly lactic-co-glycolic acid-based spray-dried nanoparticles to extend the activity of the ketoprofen lysine. Nanoparticles were produced with a spray dryer (B-90, Buchi, Switzerland) and solid state properties of nanoparticles were analyzed using scanning electron microscopy, particle size, polydispersity index, zeta potential, nuclear magnetic resonance spectroscopy, X-ray and differential scanning calorimetry. Drug release from nanoparticles was studied using the dialysis bag method in simulated gastrointestinal environment (pH 7.4). Ketoprofen lysine-loaded particles demonstrated nanostructured and spherical shape while in vitro release studies showed extended release (~8 days) of ketoprofen lysine incorporated and also a fairly good entrapment efficiency (~59-78%) was detected. Peppas-Sahlin kinetic model was found to fit the best using DDSolver software program. This research may be useful for long-term and optimum use of oral non-steroidal antiinflammatory drug in chronic inflammatory diseases.
This paper references
10.1016/j.ijpharm.2015.04.054
In vitro and in vivo evaluation of Δ⁹-tetrahidrocannabinol/PLGA nanoparticles for cancer chemotherapy.
L. Martín-Banderas (2015)
10.3109/02652048.2013.805839
Chitosan nanoparticles for ocular delivery of cyclosporine A
E. Başaran (2014)
CONTROLLED RELEASE OF PHENYTOIN SODIUM FROM CASEIN MICROPARTICLES
S. Vino (2014)
10.1080/02726351.2013.782932
Preparation and Optimization of Dry PLGA Nanoparticles by Spray Drying Technique
D. Bhambere (2013)
SUSTAINED RELEASE OF RAMIPRIL FROM AMMONIO METHACRYLATE COPOLYMER MATRIX PREPARED BY HIGH PRESSURE HOMOGENIZER
Satish Pandav (2014)
Parenteral pharmaceutical compositions containing ammoniumalkyl salts of 2-arylpropionic acids
M Gentile (1999)
10.4274/tjps.52523
Desloratadine-Eudragit® RS100 Nanoparticles: Formulation and Characterization
E. Yenilmez (2017)
10.3797/scipharm.1211-20
Rivastigmine-Loaded L-Lactide-Depsipeptide Polymeric Nanoparticles: Decisive Formulation Variable Optimization
Kunal P. Pagar (2013)
Synthesis, characterization and in vitro degradation of poly (dl-lactide)/poly (dl-lactide-coglycolide) films
M Gümüşderelioğlu (1999)
10.1002/jcp.26102
Differential protein modulation by ketoprofen and ibuprofen underlines different cellular response by gastric epithelium
L. Brandolini (2018)
10.1208/s12248-010-9185-1
DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles
Y. Zhang (2010)
10.2478/acph-2013-0027
Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal Candidiasis
N. V. Gupta (2013)
Dexketoprofen trometamol-loaded kollidon® SR and eudragit® RS 100 polymeric nanoparticles: formulation and ın vitro-ın vivo evaluation
AA Öztürk (2017)
10.14891/ANALSCISP.17ICAS.0.I785.0
FT-Raman and FT-IR Spectra of the Non-steroidal Anti-inflammatory Drug Ketoprofen Included in Cyclodextrins
S. Choi (2002)
10.1080/02652040400026285
Praziquantel-loaded PLGA nanoparticles: preparation and characterization
R. Mainardes (2005)
10.3109/03639045.2012.758130
Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting
Bhavna (2014)
Recent biomedical applications and patents on biodegradable polymer
Tanurajvir Kaur (2014)
10.1002/jcp.24809
Gastroprotective Effects of L‐Lysine Salification of Ketoprofen in Ethanol‐Injured Gastric Mucosa
A. Cimini (2015)
10.1016/J.PROGPOLYMSCI.2011.01.001
Polymer nanoparticles: Preparation techniques and size-control parameters
J. D. Rao (2011)
Makalesi POLYMERIC NANOPARTICLES
S. Derman (2013)
10.1016/j.ejpb.2009.02.013
The use of Eudragit RS 100/cyclodextrin nanoparticles for the transmucosal administration of glutathione.
A. Lopedota (2009)
FTIR AND FT-RAMAN SPECTRAL ANALYSIS OF PACLITAXEL DRUGS
T. Devi (2010)
10.1155/2014/204925
Evaluation of the DDSolver Software Applications
Jieyu Zuo (2014)
10.17485/IJST/2009/V2I10/30719
Spray Drying Technology: an overview
R. Patel (2009)
10.1016/j.colsurfb.2009.09.001
Biodegradable polymeric nanoparticles based drug delivery systems.
A. Kumari (2010)
10.1016/j.ijpharm.2011.05.049
The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems--a review.
S. Fredenberg (2011)
10.1016/J.TRAC.2016.01.012
Recent advances on the characterization of nanoparticles using infrared spectroscopy
Á. I. López-Lorente (2016)
10.1590/S1516-93322006000400007
Thermoanalytical study of praziquantel-loaded PLGA nanoparticles
R. Mainardes (2006)
Cannabinoid derivate-loaded PLGA nanocarriers for oral administration: formulation, characterization, and cytotoxicity studies
Lucía Martín Banderas (2012)
10.4274/tjps.69855
Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation
E. Başaran (2017)
10.1615/CRITREVTHERDRUGCARRIERSYST.2013006475
Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights.
D. J. Hines (2013)
10.1080/10826070801925532
Development and Validation of a HPLC Method for the Simultaneous Determination of Ketoprofen Lysine Salt and Preservative in OKI® Spray
R. Anacardio (2008)
10.1007/12_2011_150
Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
T. Akagi (2011)
Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a (1)H-NMR study.
V. Jenning (2000)
10.1016/j.ejps.2017.12.012
Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan‐alginate polyelectrolyte microparticles as a controlled drug delivery system
Janitha M. Unagolla (2018)
10.1046/j.1460-9592.2003.01089.x
Analgesic efficacy and tolerability of ketoprofen lysine salt vs paracetamol in common paediatric surgery. A randomized, single‐blind, parallel, multicentre trial
A. Messeri (2003)
10.1080/03639045.2016.1195401
Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt
Andrea Cerciello (2016)
10.1016/j.ijpharm.2013.03.030
Non-steroidal anti-inflammatory drug for pulmonary administration: design and investigation of ketoprofen lysinate fine dry powders.
Mariateresa Stigliani (2013)
10.1016/J.JDDST.2016.06.010
The simultaneous delivery of paclitaxel and Herceptin® using solid lipid nanoparticles: In vitro evaluation
G. Büyükköroğlu (2016)
10.1590/S1984-82502016000400008
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling
Jaqueline Carneiro (2016)
Formulation and characterization of clarithromycin based nanoparticulate drug delivery system
R. Thagele (2011)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar