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Pathophysiology Of Colorectal Peritoneal Carcinomatosis: Role Of The Peritoneum

Lieselotte Lemoine, Paul H Sugarbaker, Kurt van der Speeten
Published 2016 · Medicine
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Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Besides the lymphatic and haematogenous routes of dissemination, CRC frequently gives rise to transcoelomic spread of tumor cells in the peritoneal cavity, which ultimately leads to peritoneal carcinomatosis (PC). PC is associated with a poor prognosis and bad quality of life for these patients in their terminal stages of disease. A loco-regional treatment modality for PC combining cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy has resulted in promising clinical results. However, this novel approach is associated with significant morbidity and mortality. A comprehensive understanding of the molecular events involved in peritoneal disease spread is paramount in avoiding unnecessary toxicity. The emergence of PC is the result of a molecular crosstalk between cancer cells and host elements, involving several well-defined steps, together known as the peritoneal metastatic cascade. Individual or clumps of tumor cells detach from the primary tumor, gain access to the peritoneal cavity and become susceptible to the regular peritoneal transport. They attach to the distant peritoneum, subsequently invade the subperitoneal space, where angiogenesis sustains proliferation and enables further metastatic growth. These molecular events are not isolated events but rather a continuous and interdependent process. In this manuscript, we review current data regarding the molecular mechanisms underlying the development of colorectal PC, with a special focus on the peritoneum and the role of the surgeon in peritoneal disease spread.
This paper references
Absorption from the peritoneal cavity: SEM study of the mesothelium covering the peritoneal surface of the muscular portion of the diaphragm.
E C Tsilibary (1977)
A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity.
Johanna A. Tol (2008)
Biology of the peritoneum in normal homeostasis and after surgical trauma.
J B C van der Wal (2007)
VEGF Expression Predicts Survival in Patients with Peritoneal Surface Metastases from Mucinous Adenocarcinoma of the Appendix and Colon
Jocelyn M. Logan-Collins (2007)
Overexpression of Vascular Endothelial Growth Factor A in Invasive Micropapillary Colorectal Carcinoma.
Marilin Rosa (2015)
Cancer of the stomach.
Leon Gilbert Simon (1951)
A study of ascites using lymphoscintigraphy with 99m Tc-sulfur colloid.
Geoffrey E. Coates (1973)
Role of adhesion molecules in locoregional cancer spread.
Marc E. Bracke (2007)
Autofluorescent Imaging in Patients With Peritoneal Carcinomatosis
Philipp von Breitenbuch (2014)
Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer
Tae-Dong Kim (2006)
Recent advances in the research of lymphatic stomata.
Zibin Wang (2010)
Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage.
Peter Ring (1997)
Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth.
Scott A. Gerber (2006)
Invasive growth: a MET-driven genetic programme for cancer and stem cells
Carla Boccaccio (2006)
Phase II Trial
John Graham-Pole (1994)
Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
Kurt van der Speeten (2011)
Stromal fibroblasts in cancer initiation and progression
Neil A. Bhowmick (2004)
Single alteration ofp53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer
Marc Pocard (2001)
Current treatment options for colon cancer peritoneal carcinomatosis.
Tomoyoshi Aoyagi (2014)
Different matrix micro-environments in colon cancer and diverticular disease
Uwe Klinge (2006)
CD44v6 expression in patients with stage II or stage III sporadic colorectal cancer is superior to CD44 expression for predicting progression.
Lanlan Zhao (2015)
Analysis of prognostic factors in seventy patients having a complete cytoreduction plus perioperative intraperitoneal chemotherapy for carcinomatosis from colorectal cancer.
Rodrigo Gomes da Silva (2006)
Peritoneovenous shunting for ascites in cancer patients.
J. Oosterlee (1980)
Published by Baishideng Publishing Group Inc 8226 Regency Drive
Role of cancer cell-stroma interaction in invasive growth of cancer cells
Hiroaki Kataoka (2011)
Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes.
Yoshitaka Hippo (2001)
E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.
Sina Dorudi (1993)
Expression of Vascular Endothelial Growth Factor D Is Associated with Lymph Node Metastasis in Human Colorectal Carcinoma
Hiroshi Funaki (2003)
Morpho-physiological function and role of omental milky spots as omentum-associated lymphoid tissue (OALT) in the peritoneal cavity.
Masataka Shimotsuma (1993)
Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells.
Martijn S. Scheffers (2002)
The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer
Anusha Hettiaratchi (2007)
Structure and function of mesothelial cells.
Steven E. Mutsaers (2007)
Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing.
Tao Xie (2014)
Met-driven invasive growth involves transcriptional regulation of Arhgap12
Antonio Gentile (2008)
The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium.
Structure and Function.
Hugon Kowarzyk (1910)
Hyperthermic intraperitoneal doxorubicin: pharmacokinetics, metabolism, and tissue distribution in a rat model
Pierre Jacquet (1997)
Staged laparoscopic infusion of hyperthermic intraperitoneal chemotherapy after cytoreductive surgery
Amy Knutsen (2006)
Effects of cytokines on the expression of cell adhesion molecules by cultured human omental mesothelial cells.
Carol Klein (1995)
. Results in 267 patients
HH Leveen (1966)
Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study.
Dominique M Elias (2010)
Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum
Astrid E. Greijer (2008)
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis.
Jill K. Slack-Davis (2009)
Tissue status of epidermal growth factor and its receptor as an indicator of poor prognosis in patients with gastric cancer.
Yutaka Yonemura (1991)
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
Setsuo Hirohashi (1998)
CD 44 v 6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer
S Saito (2013)
Intracavitary administration of radioactive isotopes in the control of effusions due to cancer. Results in 267 patients.
Irving M. Ariel (1966)
Peritoneal carcinoma
DG Jayne (2014)
Laparoscopic hyperthermic intraperitoneal chemotherapy as adjuvant modality following radical surgery for advanced rectal cancer a new look to an old problem.
Nikolaos J. Lygidakis (2010)
Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study.
Olivier Glehen (2003)
Studies on transport of macromolecules and small particles across mesothelial cells of the mouse omentum. II. Kinetic features and metabolic requirements.
Martha E. Fedorko (1971)
Primary and secondary disease of the peritoneum and mesentery: review of anatomy and imaging features
Ashish P Wasnik (2014)
Tumour-expressed CD43 (sialophorin) mediates tumour-mesothelial cell adhesion
Paul Ziprin (2004)
Laparoscopic Environmental Changes during Surgery Enhance the Invasive Potential of Tumours
Paraskevas Paraskeva (2005)
A simplified approach to hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) using a self retaining retractor.
Paul H Sugarbaker (1996)
Mesothelial primary cilia of peritoneal and other serosal surfaces.
Stephen D. Bird (2004)
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.
Dominador J. Manalo (2005)
Synthesis and assembly of the hyaluronan-containing coats around normal human mesothelial cells.
Paraskevi Heldin (1993)
Role of Matrix Metalloproteinase-7 (Matrilysin) in Human Cancer Invasion, Apoptosis, Growth, and Angiogenesis
Masanori Ii (2006)
mTOR signaling in polycystic kidney disease.
Oxana Ibraghimov-Beskrovnaya (2011)
Peritoneum as the first-line of defense in carcinomatosis.
Paul H Sugarbaker (2007)
Metastatic pattern in colorectal cancer is strongly influenced by histological subtype.
Niek Hugen (2014)
Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients.
Naoual Bakrin (2013)
Cytoreduction and HIPEC in The Netherlands: Nationwide Long-term Outcome Following the Dutch Protocol
Anke M. J. Kuijpers (2013)
Molecular and cellular aspects of the insulin-like growth factor I receptor.
Derek Leroith (1995)
Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression.
Vera J. M. Wielenga (1993)
Tumour-induced apoptosis in human mesothelial cells: a mechanism of peritoneal invasion by Fas Ligand/Fas interaction
Roseanna Michelle Heath (2004)
Management of peritoneal-surface malignancy: the surgeon’s role
Paul H Sugarbaker (1999)
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O 2 tension
Bing-Hua Jiang (2002)
Intraperitoneal cancer dissemination: Mechanisms of the patterns of spread
C. Pablo Carmignani (2004)
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
Kazushige Hanaoka (2000)
Invasive growth: a MET-driven
C Boccaccio (2008)
Hallmarks of cancer: the next
D Hanahan (1996)
A perspective on clinical research strategies in carcinoma of the large bowel
Paul H Sugarbaker (1991)
Prognostic value of isolated peritoneal versus other metastatic sites in colorectal cancer (CRC) patients treated by systemic chemotherapy: Findings from 9,265 pts in the ARCAD database.
Jan Franko (2016)
Risk-reducing laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for low-grade appendiceal mucinous neoplasm: early outcomes and technique
Rebecca Fish (2013)
A new standard of care for the management of peritoneal surface malignancy.
Faheez Mohamed (2011)
Metastatic pattern of CC531 colon carcinoma cells in the abdominal cavity: an experimental model of peritoneal carcinomatosis in rats.
A M Lopes Cardozo (2001)
Inhibition of CD 44 expression by small interfering RNA to suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo
CZ Li (2008)
The Role of Transforming Growth Factor α in Determining Growth Factor Independence
Rana A. Awwad (2003)
Scanning and transmission electron microscopic study of visceral and parietal peritoneal regions in the rat.
Krassimira N Michailova (1999)
The role of gelatinases in colorectal cancer progression and metastasis.
Olaf R.F. Mook (2004)
Structure and function of matrix metalloproteinases and TIMPs.
Hideaki Nagase (2006)
A possible role of cytokines in the formation of peritoneal dissemination.
Yutaka Yonemura (1997)
Hyperthermic intraperitoneal gemcitabine chemotherapy for patients with resected pancreatic cancer: Clinical pharmacologic data
PH Sugarbaker (2014)
Combined laparoscopic cytoreductive surgery and hyperthermic intraperitoneal 43 Journal of Gastrointestinal Oncology Vol 7, No 1 February 2016 © Journal of Gastrointestinal Oncology
J Esquivel (2009)
Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites.
Alfredo Garofalo (2006)
A multicentric trial (Olympia-MITO 13) on the accuracy of laparoscopy to assess peritoneal spread in ovarian cancer.
Anna Fagotti (2013)
Endothelial cadherins and tumor angiogenesis.
Ugo Cavallaro (2006)
Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response.
Michael Leunig (1992)
Long-term results after proactive management for locoregional control in patients with colonic cancer at high risk of peritoneal metastases
Paolo Sammartino (2014)
Tumour seeding in peritoneal wound sites in relation to growth-factor expression in early granulation tissue.
S Zeamari (2004)
Minimally invasive secondary cytoreduction plus HIPEC for recurrent ovarian cancer: a case series.
Anna Fagotti (2014)
VEGF-B promotes cancer metastasis through a VEGF-A–independent mechanism and serves as a marker of poor prognosis for cancer patients
Xiaojuan Yang (2015)
Autocrine VEGF Signaling Is Required for Vascular Homeostasis
Sunyoung Lee (2007)
MMP-9 Is Differentially Expressed in Primary Human Colorectal Adenocarcinomas and Their Metastases
Martin Illemann (2006)
Early postoperative intraperitoneal chemotherapy as an adjuvant therapy to surgery for peritoneal carcinomatosis from gastrointestinal cancer: pharmacological studies.
Paul H Sugarbaker (1990)
Diagnostic accuracy of hand-assisted laparoscopy in predicting resectability of peritoneal carcinomatosis from gynecological malignancies.
C Varnoux (2013)
Reduction of peritoneal trauma by using nonsurgical gauze leads to less implantation metastasis of spilled tumor cells.
Petrousjka M van den Tol (1998)
c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Kenjiro Sawada (2007)
A survey of practice in management of malignant ascites.
C W Lee (1998)
Colorectal cancer statistics, 2014.
Rebecca L Siegel (2014)
CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer.
Seiya Saito (2013)
Laparoscopy in the Management of Peritoneal Carcinomatosis
Alfredo Garofalo (2009)
CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.
Tomoaki Fujisaki (1999)
New prospects for the control of peritoneal surface dissemination of gastric cancer using perioperative intraperitoneal chemotherapy
Kaiumarz Sethna (2004)
The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini.
Helen Hoffmeister (2011)
A three-dimensional in-vitro model for the study of peritoneal tumour metastasis
David G. Jayne (2004)
Cellular composition of milky spots in the human greater omentum: an immunochemical and ultrastructural study.
Lambert F. G. Krist (1995)
An overview of peritonectomy, visceral resections, and perioperative chemotherapy for peritoneal surface malignancy
PH Sugarbaker (2012)
Heated intraoperative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis: Pharmacokinetics and tissue distribution
D Elias (2002)
Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
Akihiro Sako (2006)
New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?
Paul H Sugarbaker (2006)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan (2011)
EMT, the cytoskeleton, and cancer cell invasion
Mahmut Sinan Yilmaz (2008)
Results of Systematic Second-look Surgery Plus HIPEC in Asymptomatic Patients Presenting a High Risk of Developing Colorectal Peritoneal Carcinomatosis
Dominique M Elias (2011)
Preoperative assessment of peritoneal carcinomatosis in patients undergoing hyperthermic intraperitoneal chemotherapy following cytoreductive surgery.
Enrico Maria Pasqual (2014)
Inhibition of CD44 expression
CZ Li (2001)
Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer.
Da-Qiang Seetoo (2003)
Expression of adhesion molecules and chemotactic cytokines in cultured human mesothelial cells
Nives Jonjić (1992)
The Host's Initial Response to Peritoneal Infection: The Pivotal Role of the Mesothelial Cell
Nicholas Topley (1995)
Is Palliative Laparoscopic Hyperthermic Intraperitoneal Chemotherapy Effective in Patients with Malignant Hemorrhagic Ascites?
Louis de Mestier (2012)
Free peritoneal tumor cells detection in gastric and colorectal cancer patients.
Simone Rossi Del Monte (2012)
RETRACTED ARTICLE: Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis
Chun-yu Li (2012)
HGF/SF induces mesothelial cell migration and proliferation by autocrine and paracrine pathways.
Richard M. Warn (2001)
Colorectal Cancer
Jack D. Hardcastle (1993)
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for colorectal cancer: choosing the right candidates
Christopher J LaRocca (2015)
Feasibility of laparoscopic peritonectomy followed by intra-peritoneal chemohyperthermia: an experimental study.
Gwénaël Ferron (2005)
E-cadherin and urokinase-type plasminogen activator tissue status in gastric carcinoma.
Yutaka Yonemura (1995)
Effect of hepatocyte growth factor on progression of liver metastasis in colorectal cancer.
Shinji Osada (2010)
Influence of colorectal laparoscopic surgery on dissemination and seeding of tumor cells
Cai Jing-li (2005)
Autocrine transforming growth factor-alpha is associated with progression of transformed properties in human colon cancer cells.
Barry L. Ziober (1993)
Interaction of murine peritoneal leukocytes and mesothelial cells: in vitro model system to survey cellular events on serosal membranes during inflammation.
Jana Müller (1995)
Identification of Early-Stage Colorectal Cancer Patients at Risk of Relapse Post-Resection by Immunobead Reverse Transcription-PCR Analysis of Peritoneal Lavage Fluid for Malignant Cells
Julia Marianne Lloyd (2006)
Malignant pseudomyxoma of colonic origin. Natural history and presentation of a curative approach to treatment
PH Sugarbaker (1987)
Laparoscopic HIPEC: initial experience, opportunities and limitations
K. Van der Speeten (2006)
Heated intra-operative intraperitoneal oxaliplatin alone and in combination with intraperitoneal irinotecan: Pharmacologic studies.
Dominique M Elias (2006)
Laboratory and clinical basis for hyperthermia as a component of intracavitary chemotherapy
Paul H Sugarbaker (2007)
Laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) in the management of refractory malignant ascites: A multi-institutional retrospective analysis in 52 patients.
Mario Valle (2009)
Peritoneal carcinomatosis from colorectal cancer.
D. G. Jayne (2002)
Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.
Graeme I Murray (1996)
The Polycystic Kidney Disease-1 Protein, Polycystin-1, Binds and Activates Heterotrimeric G-Proteinsin Vitro
Stephen C. Parnell (1998)
Quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: a prospective study of 216 patients.
G Passot (2014)
aggressive phenotypes in colorectal cancer
O Ibraghimov-Beskrovnaya (2015)
Extensive Intraoperative Peritoneal Lavage as a Standard Prophylactic Strategy for Peritoneal Recurrence in Patients with Gastric Carcinoma
Masafumi Kuramoto (2009)
Peritoneal-plasma barrier.
Patrice Jacquet (1996)
Gastrointestinal Oncology Vol 7, No 1 February 2016 © Journal of Gastrointestinal Oncology
K Van der Speeten (2012)
For the clinical application of thermochemotherapy given at mild temperatures.
Muneyasu Urano (1999)
The Ability of Existing Questionnaires to Measure Symptom Change After Paracentesis for Symptomatic Ascites
Alexandra M Easson (2007)
28 electron microscopic study of visceral and parietal peritoneal regions in the rat
SE Mutsaers (1999)
Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: a multi-institutional study of 1,290 patients.
Olivier Glehen (2010)
Changes in the concentration of microvilli on the free surface of healing mesothelium are associated with alterations in surface membrane charge.
Steven E. Mutsaers (1996)
H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK
Monica M Olcina (2016)
Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival
Rob Kwakman (2015)
Prognostic factors for stage III epithelial ovarian cancer treated with intraperitoneal chemotherapy: a Gynecologic Oncology Group study.
Lisa Michelle Landrum (2013)
Peritoneal Carcinomatosis: Cytoreductive Surgery and HIPEC–-Overview and Basics
Björn L.D.M. Brücher (2012)
Increased Tissue Diffusion of Oxaliplatin During Laparoscopically Assisted Versus Open Heated Intraoperative Intraperitoneal Chemotherapy (HIPEC)
Fabienne Thomas (2008)
Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.
Gavin R. Screaton (1992)
Pancreatic carcinoma.
Oluwole Gbolagunte Ajao (1980)
A perspective on clinical research strategies in WJG|
PH Sugarbaker (2004)
Pathophysiology of colorectal peritoneal carcinomatosis mouse omentum. II. Kinetic features and metabolic requirements
L Lemoine (1971)
Stromal fibroblasts
NA Bhowmick (1906)
The Physiologic Effects
Janet Hoffman Mennies (1983)
Influence of colorectal laparoscopic
C Jingli (2002)
Contribution of host-derived growth factors to in vivo growth of a transplantable murine mammary carcinoma.
Donna E Davies (1994)
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
In Kyu Lee (2013)
Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
Raymond M. Shaheen (2001)
The short- and longterm outcomes of laparoscopic versus open surgery for colorectal cancer: a meta-analysis
CL Wang (2014)
Prognostic Value of Peritoneal Cytology and the Combination of Peritoneal Cytology and Peritoneal Dissemination in Colorectal Cancer
Takeshi Nishikawa (2009)
Serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) in colorectal cancer patients
Magdalena Groblewska (2013)
Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma.
Sivan Elloul (2005)
Identification of serosal invasion and extramural venous invasion on review of Dukes' stage B colonic carcinomas and correlation with survival.
Colin J R Stewart (2007)
Structure and function of placental growth factor.
Sandro De Falco (2002)
Role of Versican, Hyaluronan and CD44 in Ovarian Cancer Metastasis
Miranda P Ween (2011)
Closed Hyperthermic Intraperitoneal Chemotherapy with Open Abdomen: a Novel Technique to Reduce Exposure of the Surgical Team to Chemotherapy Drugs
Laurent Benoit (2007)
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.
Janice A. Nagy (1995)
Peritoneovenous shunts for ascites
HH Leveen (1974)
Role of hyperthermic intraoperative peritoneal chemotherapy in the management of peritoneal metastases.
Dominique M Elias (2014)
Polycystin-1: function as a mechanosensor.
Georgia Dalagiorgou (2010)
The Physiologic Effects of Laparoscopy: Applications in Oncology
James Ouellette (2005)
Metastasis Suppressors and the Tumor Microenvironment
Thomas M. Bodenstine (2008)
Oxidative stress-dependent increase in ICAM-1 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal mesothelium.
Krzysztof Książek (2010)
Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 as a prognostic factor in human colorectal carcinomas.
Toshikatsu Fujii (1999)
MMP-7 as a prognostic marker in colorectal cancer
Selja Koskensalo (2010)
Rationale for hyperthermia with intraoperative intraperitoneal chemotherapy agents.
Robert P. Sticca (2003)
Adhesion of Gastric Carcinoma Cells to Peritoneum Mediated by α3β1 Integrin (VLA-3)
Hironori Takatsuki (2004)
Subcellular localization and trafficking of polycystins
Michael Köttgen (2005)
Molecular biology of peritoneal carcinomatosis.
David G. Jayne (2007)
Pseudomyxoma peritonei and peritoneal metastases from appendiceal malignancy
PH Sugarbaker (2012)
The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: a comparative study.
Daphne Hompes (2014)
Impact of surgical and clinical factors on the pharmacology of intraperitoneal doxorubicin in 145 patients with peritoneal carcinomatosis.
Paul H Sugarbaker (2011)
Colorectal cancer statistics
R Siegel (2014)
Improving drug delivery to solid tumors: priming the tumor microenvironment.
Iftikhar Ali Khawar (2015)
Catumaxomab: in malignant ascites.
James E. Frampton (2012)
A Phase I Trial of Thermal Sensitization Using Induced Oxidative Stress in the Context of HIPEC
Lawrence E. Harrison (2013)
8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer
Vic J. Verwaal (2008)
Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies
Manuel J. Koppe (2006)
ICAM-1 Mediated Tumor-Mesothelial Cell Adhesion is Modulated by IL-6 and TNF-α: A Potential Mechanism by Which Surgical Trauma Increases Peritoneal Metastases
Paul Ziprin (2003)
Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis
Hongxia Chen (2015)
Malignant ascites: systematic review and guideline for treatment.
Gerhild Becker (2006)
Chirurgia Oncologica (SICO). PROMENADE Trial (PROactive Management of ENdoperitoneal spreAD in colonic cancer).2015
P Sammartino (2015)
Effect of inflammatory cytokines and growth factors on tumour cell adhesion to the peritoneum.
M E E van Rossen (2001)
Malignant ascites: past, present, and future.
Rony A. Adam (2004)
Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial
Charlotte E. L. Klaver (2015)
Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy improves survival in patients with colorectal peritoneal metastases compared with systemic chemotherapy alone
Reza Mirnezami (2014)
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension.
Bin Jiang (1996)
The Polycystic Kidney Disease 1 Gene Encodes a 14 kb Transcript and Lies within a Duplicated Region on Chromosome 16
Christopher J. Ward (1994)
Mesothelial stomata overlying omental milky spots: Scanning electron microscopic study
Vladimir A. Mironov (2004)
Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.
Antonios N Gargalionis (2015)
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia.
Bradley K. Yoder (2002)
Molecular detection ( kras ) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer ?
Annette Torgunrud Kristensen (2008)
Omental milky spots in screening gastric cancer stem cells.
L Q Cao (2011)
Role of Peritoneal Lavage Cytology and Prediction of Prognosis and Peritoneal Recurrence After Curative Surgery for Colorectal Cancer
Sung Joon Bae (2014)
Targeting HIF-1 for cancer therapy
Gregg L Semenza (2003)
Epidermal growth factor receptor family in lung cancer and premalignancy.
Wilbur Franklin (2002)
Review of epidermal growth factor receptor biology.
Roy S. Herbst (2004)
Matrix metalloproteinases: a tail of a frog that became a prince
Constance E. Brinckerhoff (2002)
Observations concerning cancer spread within the peritoneal cavity and concepts supporting an ordered pathophysiology.
Paul H Sugarbaker (1996)
Patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, and role of laparoscopy in diagnosis, staging, and treatment.
Mario Valle (2012)
Recent advances in the research
ZB Wang (2013)
Peritoneal carcinomatosis of colorectal origin: Incidence, prognosis and treatment options.
Yvonne L. B. Klaver (2012)
Long-Term Prognostic Value of Conventional Peritoneal Lavage Cytology in Patients Undergoing Curative Colorectal Cancer Resection
Shingo Noura (2009)
Site-Specific Gene Expression Profiles and Novel Molecular Prognostic Factors in Patients with Lower Gastrointestinal Adenocarcinoma Diffusely Metastatic to Liver or Peritoneum
Sheelu Varghese (2007)
Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells.
Andrea L. Veatch (1994)
Tumor Cell Dissemination during Laparoscopy: Prevention and Therapeutic Opportunities
Ralf Steinert (2002)
c-Met: Structure, functions and potential for therapeutic inhibition
Patrick C. H. Ma (2004)
Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels.
Katsuhiro Hayashi (2007)
A review of peritoneal mesothelioma at the Washington Cancer Institute.
Paul H Sugarbaker (2003)
Changes induced by surgical and clinical factors in the pharmacology of intraperitoneal mitomycin C in 145 patients with peritoneal carcinomatosis
Kurt Van der Speeten (2010)
Second-Look Surgery for Colorectal Cancer: Revised Selection Factors and New Treatment Options for Greater Success
Paul H Sugarbaker (2011)
The significance of involvement of a free serosal surface for recurrence and survival following resection of clinicopathological stage B and C rectal cancer.
Anil Keshava (2007)
Transmembrane domain analysis of polycystin-1, the product of the polycystic kidney disease-1 (PKD1) gene: evidence for 11 membrane-spanning domains.
Nancy M Nims (2003)
Evidence-based medicine in the treatment of peritoneal carcinomatosis: Past, present, and future.
Aviram Nissan (2009)
Pleurectomy/decortication, hyperthermic pleural lavage with povidone-iodine, prophylactic radiotherapy, and systemic chemotherapy in patients with malignant pleural mesothelioma: a 10-year experience.
Loïc Lang-Lazdunski (2015)
Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer
Yugang Wu (2010)
Laparoscopic Diagnosis and Laparoscopic Hyperthermic Intraoperative Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei Detected by CT Examination
Masamitsu Hirano (2012)
The microfilament system and malignancy.
U. E. P. Lindberg (2008)
Induction of Proteases in Peritoneal Carcinomatosis, the Role of ICAM-1/CD43 Interaction
Nawar A. Alkhamesi (2007)
Polycystin-2 is an intracellular calcium release channel
Peter Koulen (2002)
Plasma Insulin-like Growth Factors, Insulin-like Binding Protein-3, and Outcome in Metastatic Colorectal Cancer: Results from Intergroup Trial N9741
Charles S. Fuchs (2008)
Inflammatory Cytokines Stimulate the Adhesion of Colon Carcinoma Cells to Mesothelial Monolayers
Wilhelmina M U van Grevenstein (2007)
Mechanisms of tissue repair: from wound healing to fibrosis.
Steven E. Mutsaers (1997)
Cytoreductive Surgery and HIPEC in Recurrent Epithelial Ovarian Cancer: A Prospective Randomized Phase III Study
John Spiliotis (2014)
Morphology of the peritoneum in CAPD.
James W. Dobbie (1989)
Phosphatidylcholine synthesis by peritoneal mesothelium: its implications for peritoneal dialysis.
James W. Dobbie (1988)
American Society of Peritoneal Surface Malignancies opinion statement on defining expectations from cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with colorectal cancer.
Jesús Esquivel (2014)
Peritoneal carcinomatosis is less frequently diagnosed during laparoscopic surgery compared to open surgery in patients with colorectal cancer.
Irene Thomassen (2014)
Endothelial cadherins
U Cavallaro (2007)
E-mail: Help Desk:
Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer.
Josefin Segelman (2012)
Roles of VLA-2 and VLA-3 on the formation of peritoneal dissemination in gastric cancer.
Yutaka Yonemura (1996)
The Expression of Adhesion Molecules and the Influence of Inflammatory Cytokines on the Adhesion of Human Pancreatic Carcinoma Cells to Mesothelial Monolayers
Wilhelmina M U van Grevenstein (2006)
Malignant Ascites: Clinical and Experimental Observations
Richard Neal Garrison (1986)
ICAM-1 Mediated Peritoneal Carcinomatosis, A Target for Therapeutic Intervention
Nawar A. Alkhamesi (2005)
Laparoscopic versus open total mesorectal excision for rectal cancer.
Stéphanie O. Breukink (2006)
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
D Shweiki (1992)
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Takanobu Yamada (2010)
Co-expression of EGF receptor, TGFα and S6 kinase is significantly associated with colorectal carcinomas with distant metastases at diagnosis
Marco Tampellini (2007)
Free peritoneal tumor cells detection in gastric and colorectal cancer patients
Vincenzo Ziparo (2013)
Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer.
Marja Hilska (2007)
The role of laparoscopy to evaluate candidates for complete cytoreduction of peritoneal carcinomatosis and hyperthermic intraperitoneal chemotherapy.
Christophe Pomel (2005)
Update on chemotherapeutic agents utilized for perioperative intraperitoneal chemotherapy.
Paul H Sugarbaker (2005)
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs
A Jung (2005)
Role of versican, hyaluronan
MP Ween (1939)
Feasibility of adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy in a short stay setting in patients with colorectal cancer at high risk of peritoneal carcinomatosis.
D. A. M. Sloothaak (2014)
Interaction of rat ascites hepatoma cells with cultured mesothelial cell layers: a model for tumor invasion.
Hitoshi Akedo (1986)
Lack of prognostic role of pre- and postoperative peritoneal cytology and cytokeratin PCR-expression on local recurrence after curative anterior resection for mid-low rectal cancer
Donato Francesco Altomare (2011)
Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer
Kouichirou Tahara (2010)
Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy
V. Catalano (2009)
Invasion and Metastasis in Colorectal Cancer: Epithelial-Mesenchymal Transition, Mesenchymal-Epithelial Transition, Stem Cells and β-Catenin
Thomas Brabletz (2005)
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.
Vic J. Verwaal (2003)
Colorectal cancer statistics, 2014
Rebecca L. Siegel Mph (2014)
Definition of Patients Presenting a High Risk of Developing Peritoneal Carcinomatosis After Curative Surgery for Colorectal Cancer: A Systematic Review
Charles Honoré (2012)
Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3).
Hironori Takatsuki (2004)
The regional difference of pleural mesothelial cells in rabbits.
N S Wang (1974)
Mechanisms of the formation of the peritoneal dissemination in gastric cancer.
Yutaka Yonemura (1996)
Tumor cells in blood shed from the surgical field.
Emil Hansen (1995)
Malignant ascites: pathophysiology and treatment
Emanuel Cavazzoni (2012)
The past, the present and future of the OK-432 therapy for patients with malignant effusions.
Mitsuo Katano (1998)
Role of explorative laparoscopy to evaluate optimal candidates for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal mesothelioma.
Barbara Laterza (2009)
The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery.
Arancha Prada-Villaverde (2014)
Peritoneal metastases of colorectal origin treated by cytoreduction and HIPEC: An overview.
Alvaro Arjona-Sánchez (2014)
Phase I study and pharmacological studies of adriamycin administered intraperitoneally to patients with ovarian cancer
RF Ozols (2016)
Structure and function of matrix
H Nagase (1994)
omental milky spots: scanning electron microscopic study
K Michailova (1979)
Recent insights into the pathophysiology of omental metastases.
Manuel J. Koppe (2014)
Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells.
Nao Harada (2001)
Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of malignant ascites secondary to unresectable peritoneal carcinomatosis from advanced gastric cancer.
Enrico Facchiano (2008)
Port-site metastasis in the abdominal wall: fact or fiction?
Raghu S Savalgi (1998)
Epidermal growth factor-related peptides and their receptors in human malignancies.
David S. Salomon (1995)
Basic Calcium Phosphate Crystals Induce Matrix Metalloproteinase-1 through the Ras/Mitogen-activated Protein Kinase/c-Fos/AP-1/Metalloproteinase 1 Pathway
Yubo Sun (2002)
The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.
Stephen C. Parnell (1998)
Adjuvant HIPEC in High Risk Colon Cancer ( COLOPEC )
P Sammartino (2015)
The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit.
J. Stretton Young (1950)
Postoperative outcomes of laparoscopic vs open cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for treatment of peritoneal surface malignancies.
G Passot (2014)
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Lei-ming Xu (2000)
Omental milky spots in screening
L Cao (1993)
Introduction of antisense CD44S
I Sasaki (2016)
Inhibition of CD44 expression by small interfering RNA to suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo.
C Li (2008)
The pathogenesis of malignant ascites.
Jouke T. Tamsma (2007)
The role of transforming growth factor alpha in determining growth factor independence.
Rana A. Awwad (2003)
MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.
Eiji Sunami (2000)
Successful Palliation of Malignant Ascites From Peritoneal Mesothelioma by Laparoscopic Intraperitoneal Hyperthermic Chemotherapy
Alberto Patriti (2008)
GASTRICHIP: D2 resection and hyperthermic intraperitoneal chemotherapy in locally advanced gastric carcinoma: a randomized and multicenter phase III study
Olivier Glehen (2013)
Laparoscopic Cytoreductive Surgery and HIPEC in Patients with Limited Pseudomyxoma Peritonei of Appendiceal Origin
Jesús Esquivel (2012)
Serum matrilysin correlates with poor survival independently of KRAS and BRAF status in refractory advanced colorectal cancer patients treated with irinotecan plus cetuximab
Xabier García-Albéniz (2010)
Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?
Annette Torgunrud Kristensen (2008)

This paper is referenced by
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Magdalena M Gilg (2018)
Peritoneal Spaces. Measurements of peritoneal surfaces
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Long-term oncologic outcomes of stent as a bridge to surgery versus emergency surgery in malignant left side colonic obstructions: a meta-analysis.
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Impairments in Bowel Function, Social Function and Quality of Life After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Zubair Bayat (2019)
Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential1
Soon-Chan Kim (2018)
Mechanisms of Metastasis in Colorectal Cancer and Metastatic Organotropism: Hematogenous versus Peritoneal Spread
E. Pretzsch (2019)
Effect of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy on relapse pattern in primary epithelial ovarian cancer: a propensity score based case-control study
Marco Ceresoli (2018)
Comparison of implantation sites for the development of peritoneal metastasis in a colorectal cancer mouse model using non-invasive bioluminescence imaging
Abdelkader Taibi (2019)
Mechanical destruction of tumor microenvironment through rotating magnetic field-induced torque of nanoparticles
Thierry Michy (2019)
Role of Peritoneal Cytology in Patients with Early Stage Colorectal Cancer
Isabel María Gallarín Salamanca (2019)
Long-term outcomes of stent-related perforation in malignant colon obstruction: a systematic review and meta-analysis
Izaskun Balciscueta (2020)
Screening for colorectal cancer in defunctioned colons
Fayyaz Akbar (2018)
Genomics of peritoneal surface malignancies
Jasvinder Singh (2017)
Pathology of Peritoneal Metastases: The Unchartered Fields
Olivier Gléhen (2020)
Colorectal cancer peritoneal metastases: Biology, treatment and next steps.
Ilona C P A Baaten (2019)
Synchronous metastatic colon cancer and the importance of primary tumor laterality - A National Cancer Database analysis of right- versus left-sided colon cancer.
Beiqun Zhao (2019)
Cytoreductive Surgery for Peritoneal Metastases: Principles and Techniques
Aditi Bhatt (2018)
The bacterial instrument as a promising therapy for colon cancer
Atieh Yaghoubi (2020)
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