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Synthesis Of Cis-hydrindan-2,4-diones Bearing An All-carbon Quaternary Center By A Danheiser Annulation

Gisela V. Saborit, C. Cativiela, A. Jiménez, J. Bonjoch, Ben Bradshaw
Published 2018 · Chemistry, Medicine

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A straightforward synthetic entry to functionalized hydrindane compounds based on a rapid assembly of the core nucleus by a Danheiser cycloaddition is reported. Valuable bicyclic building blocks containing the fused five and six-membered carbocyclic ring system can be achieved in only four steps from a simple acyclic β-keto ester.
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