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Regioselective Addition Of Grignard Reagents To N-acylpyrazinium Salts: Synthesis Of Substituted 1,2-dihydropyrazines And Δ5-2-oxopiperazines

Valentine R St. Hilaire, William E Hopkins, Yenteeo S Miller, Srinivasa R Dandepally, Alfred L Williams

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The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihydropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ5-2-oxopiperazines providing a simple and efficient approach towards their preparation.