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Engineering Of Indole-based Tethered Biheterocyclic Alkaloid Meridianin Into β-carboline-derived Tetracyclic Polyheterocycles Via Amino Functionalization/6-endo Cationic π-cyclization

Piyush Kumar Agarwal, Meena Devi Dathi, Mohammad Saifuddin, Bijoy Kundu

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A mild, efficient and versatile method has been developed for the construction of a functionalized natural product, meridianin, and its post conversion to pyrimido-β-carboline by cationic π- cyclization. The strategy involves the introduction of an amino group at the C-5 of the pyrimidine ring and utilizing the nucleophilictiy of the C-2 in the indole ring to facilitate cationic π-cyclization.