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Individualizing Mesothelioma Treatment: Small Steps Into A Brighter Future.

L. Garland, Raja Flores, A. Tsao
Published 2010 · Medicine

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development of more effective therapies for mesothelioma, with an emphasis on individualizing mesothelioma treatment, thus remains of great interest. Mesothelioma is a disease that presents unique challenges but also significant opportunities for the development of personalized medicine. Its relative rarity, biologic heterogeneity, and inherent chemotherapy- and radiation-resistance continue to challenge efforts to discover and develop novel therapeutic strategies that can be validated in well powered randomized clinical trials. However, the availability of pleural tumor from diagnostic pleural biopsies and pleurectomy specimens provides a distinct opportunity for molecular/genetic studies that can yield prognostic and predictive biomarkers upon which individualized therapy can be designed. We expect current therapeutic strategies to evolve based on a number of recent, ground breaking studies as well as preclinical studies and clinical trials that are currently under way. Herein, we discuss opportunities for individualizing both local and systemic therapy, highlighting how mesothelioma treatment may progress over the course of the upcoming decade.
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