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Acute Effects Of Oral Calcium Carbonate With And Without The Addition Of Omeprazole And Fiber Enriched Milk On Serum Calcium Concentrations In Postmenopausal Women

Paula Aragão Prazeres Oliveira, Maria Mariana Barros Melo da Silveira, Leiliandry de Araújo Melo, Isabela Cristina Cordeiro Farias, Maria Elba Bandeira Farias, Ana Carla Peres Montenegro, Francisco Alfredo Bandeira Farias
Published 2017 · Medicine

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Introduction: In recent years, some studies have shown an increase in cardiovascular risk due to the use of calcium supplements in excess of the recommended doses. One hypothesis is that some calcium supplements lead to a more pronounced elevation of serum calcium concentrations. Objectives: The aim of this study was to evaluate the serum calcium responses after ingestion of calcium carbonate, with and without the prior use of omeprazole, and after ingestion of soluble fiber enriched milk (SFM). Method: Five postmenopausal women were evaluated in three phases. For each phase, the serum calcium responses were determined at 0h (baseline), 1h, 2h, 3h and 4h. After ingestion of 1200mg of calcium, both for the patients who received the calcium carbonate and for those who received SFM. The rise in serum calcium observed after ingestion of calcium carbonate with a calcium peak of 0.56 mg/dl (p=0.032), and it was higher when compared to SFM 0.26 mg/dl (p=0.284). There was no significant elevation of serum calcium after ingestion of SFM. Results: The calcium responses were negative after the administration of omeprazole in comparison with the use of calcium carbonate and SFM, reaching 7.06mg/dl vs 9.04mg/dl vs 9.12mg/dl at 0h, 5.30mg/dl vs 9. 32mg/dl vs 9.00mg/dl at 1hr, 5.52mg/dl vs 9.48mg/dl vs 9.32mg/dl at 2hr, 5.18mg/dl vs 9.48mg/dl vs 9.34mg/dl at, respectively. In conclusion, our data show that the same amount of SFM induced a lower serum calcium response when compared to calcium carbonate. Conclusion: The use of omeprazole significantly reduced the intestinal absorption of calcium carbonate.
This paper references
Calcium in the diet: food sources, recommended intakes, and nutritional bioavailability.
D. Miller (1989)
Absorption of calcium from milks enriched with fructo-oligosaccharides, caseinophosphopeptides, tricalcium phosphate, and milk solids.
E. López-Huertas (2006)
Acute effects of calcium citrate with or without a meal, calcium-fortified juice and a dairy product meal on serum calcium and phosphate: a randomised cross-over trial.
Sarah M Bristow (2015)
An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
G. Bo-Linn (1984)
Relative bioavailability of calcium-rich dietary sources in the elderly.
L. Martini (2002)
Postprandial metabolic responses to milk enriched with milk calcium are different from responses to milk enriched with calcium carbonate.
J. H. Green (2003)
Gastric acidity, atrophic gastritis, and calcium absorption.
R. Wood (1992)
Effect of wheat bran on bowel function and fecal calcium in older adults.
R. Balasubramanian (1987)
Acid-Suppressive Medications and Risk of Bone Loss and Fracture in Older Adults
E. Yu (2008)
Effect of Calcium Supplements on Risk of Myocardial Infarction and Cardiovascular Events: Meta-analysis
M. Bolland (2014)
Effect of gastric acid secretion on intestinal phosphate and calcium absorption in normal subjects.
G. Graziani (1995)
Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men
C. Coudray (1997)
The acute metabolic effects of oral tricalcium phosphate and calcium carbonate
R. Yang (1994)
The final word on proton pump inhibitors and osteoporosis?
Lauren B. Gerson (2013)
Effect of Guar Gum on Mineral Balances in NIDDM Adults
K. Behall (1989)
Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.
S. Gray (2010)
Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women.
H. Karp (2009)
The absorption of calcium carbonate.
P. Ivanovich (1967)
The Final Word on Proton Pump Inhibitors and Oesteoporosis? Gastroenterology
LB Gerson (2013)
Proton pump inhibitors therapy and risk of hip fracture: a systematic review and meta-analysis
Xiaofei Ye (2011)
Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.
L. Targownik (2010)
Use of Acid-Suppressive Drugs and Risk of Fracture: A Meta-analysis of Observational Studies
Chun-Sick Eom (2011)
Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women.
R. Bostick (1999)
Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.
P. Autier (2007)
Acute biochemical variations induced by four different calcium salts in healthy male volunteers
J. Reginster (2005)
Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss. Gastroenterology
LE Targownik (2010)
Effect of a High-Fiber Diet Compared With a Moderate-Fiber Diet on Calcium and Other Mineral Balances in Subjects With Type 2 Diabetes
M. Shah (2009)
Effect of oat bran muffins on calcium absorption and calcium, phosphorus, magnesium and zinc balance in men.
H. Spencer (1991)
Calcium bioavailability and absorption: a review.
L. Allen (1982)
Association of Long-Term Proton Pump Inhibitor Therapy with Bone Fractures and Effects on Absorption of Calcium, Vitamin B12, Iron, and Magnesium
T. Ito (2010)
Acute effects of calcium carbonate and milk on the calcium-parathyroid axis and bone resorption in healthy women.
V. Zikán (2001)
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)

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