Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Doxorubicin-loaded Dual-functional Hyaluronic Acid Nanoparticles: Preparation, Characterization And Antitumor Efficacy In Vitro And In Vivo

Guixiang Tian, Xiue Sun, Jingkun Bai, Jinhua Dong, B. Zhang, Zhiqin Gao, Jingliang Wu
Published 2019 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
A novel GHH copolymer was synthesized using hyaluronic acid modified with glycyrrhetinic acid and L-histidine (His), and doxorubicin-loaded GHH nanoparticles (DOX/GHH) were prepared for liver-targeted drug delivery and pH-responsive drug release. In the present study, GHH nanoparticles were characterized, and their pH-responsive behaviors were evaluated at different pH levels. The antitumor effect of the DOX/GHH nanoparticles was investigated in vitro and in vivo. Results showed that the DOX/GHH nanoparticles were spherical, and the particle sizes ranged from 238.1 to 156.7 nm with an increase in the degree of substitution of His. The GHH nanoparticles were obviously internalized into human hepatoblastoma cells. In vitro cytotoxicity assay results showed that the DOX/GHH nanoparticles exhibited a dose-dependent antitumor effect. Compared with free DOX, the DOX/GHH nanoparticles displayed higher antitumor efficacy. These results indicate that GHH nanoparticles could be a promising nano-delivery carrier of hydrophobic drugs for liver-targeted therapy.
This paper references
10.1016/j.jconrel.2017.09.014
Nanoparticles of a polyaspartamide‐based brush copolymer for modified release of sorafenib: In vitro and in vivo evaluation
M. Cervello (2017)
10.2147/IJN.S113882
The effect of dual-functional hyaluronic acid-vitamin E succinate micelles on targeting delivery of doxorubicin
J. Wang (2016)
10.1039/c6nr09639e
Synergistic chemotherapeutic effect of sorafenib-loaded pullulan-Dox conjugate nanoparticles against murine breast carcinoma.
J. Sui (2017)
10.1016/j.biomaterials.2009.09.030
Self-assembled hyaluronic acid nanoparticles for active tumor targeting.
K. Choi (2010)
10.1007/s10856-012-4665-8
Preparation and characterization of nanoparticles based on histidine–hyaluronic acid conjugates as doxorubicin carriers
Jing-liang Wu (2012)
10.2147/IJN.S135626
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
Yongjiu Lv (2017)
10.1080/09205063.2017.1288076
Preparation and characterization of a chitosan/galactosylated hyaluronic acid/heparin scaffold for hepatic tissue engineering
Jinyong Fan (2017)
10.1016/j.actbio.2017.05.013
Augmented liver targeting of exosomes by surface modification with cationized pullulan.
R. Tamura (2017)
10.1016/j.biomaterials.2014.08.008
Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin.
L. Qiu (2014)
10.1016/J.IJPHARM.2006.08.039
Effect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.
T. Kobayashi (2007)
10.1016/J.JCONREL.2007.02.011
Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels.
H. Lee (2007)
10.1088/1468-6996/14/4/044402
pH-responsive polymeric micelles with core–shell–corona architectures as intracellular anti-cancer drug carriers
B. P. Bastakoti (2013)
10.1002/adma.201204455
Highly discriminating photorelease of anticancer drugs based on hypoxia activatable phototrigger conjugated chitosan nanoparticles.
Qiuning Lin (2013)
10.1016/j.actbio.2013.12.025
Self-assembled pH-responsive hyaluronic acid-g-poly((L)-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin.
L. Qiu (2014)
10.1016/J.DRUDIS.2006.07.005
Exploiting the enhanced permeability and retention effect for tumor targeting.
A. Iyer (2006)
10.1053/j.gastro.2016.11.048
Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.
D. Sia (2017)
10.1021/acsami.7b02606
Specifically Increased Paclitaxel Release in Tumor and Synergetic Therapy by a Hyaluronic Acid-Tocopherol Nanomicelle.
Hanbo Zhang (2017)
10.1021/acsami.6b15347
Bioreducible Cross-Linked Hyaluronic Acid/Calcium Phosphate Hybrid Nanoparticles for Specific Delivery of siRNA in Melanoma Tumor Therapy.
Z. Zhou (2017)
10.1016/j.actbio.2010.04.021
Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) micelles for liver targeting therapy.
W. Huang (2010)
10.1016/j.nano.2017.06.019
Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid.
L. Lin (2017)
10.3390/ijms17040364
pH-Responsive Hyaluronic Acid-Based Mixed Micelles for the Hepatoma-Targeting Delivery of Doxorubicin
Jing-liang Wu (2016)
10.1016/j.biomaterials.2011.11.045
Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy.
Chuangnian Zhang (2012)
10.1073/pnas.1620874114
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
James E. Dahlman (2017)
10.1021/mp500394v
Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy.
Wen-Wen Qi (2015)
10.1016/j.ijpharm.2017.05.063
Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model.
Xiaofeng Han (2017)
10.1016/j.actbio.2017.09.016
Pro-inflammatory chitosan/poly(γ-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity.
Flávia Castro (2017)
10.3109/10717544.2015.1108374
Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration
Xiaofeng Han (2016)
10.1016/j.ejps.2016.09.036
Synthesis, characterization and liver targeting evaluation of self‐assembled hyaluronic acid nanoparticles functionalized with glycyrrhetinic acid
Xiaodan Wang (2017)
10.2147/IJN.S88253
Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid
J. Li (2015)
10.2147/IJN.S141982
pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity
Yan Di (2017)
10.1007/s10856-011-4494-1
Design and synthesis of dual-ligand modified chitosan as a liver targeting vector
Houxiang Chen (2011)
10.1016/j.biomaterials.2017.04.006
Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy.
X. Liang (2017)
10.1016/j.semcancer.2018.03.004
Genome sequencing analysis of liver cancer for precision medicine.
H. Nakagawa (2019)
10.1039/c5cs00798d
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems.
Mahdi Karimi (2016)
10.1016/j.biomaterials.2016.04.004
Mitochondria and nuclei dual-targeted heterogeneous hydroxyapatite nanoparticles for enhancing therapeutic efficacy of doxorubicin.
Hui Xiong (2016)
10.1063/1.3580293
A comparison of implicit- and explicit-solvent simulations of self-assembly in block copolymer and solute systems.
Justin R. Spaeth (2011)
10.1016/J.JCONREL.2006.05.017
Heparin-deoxycholic acid chemical conjugate as an anticancer drug carrier and its antitumor activity.
Kyeongsoon Park (2006)
10.1016/j.jconrel.2012.06.027
pH-sensitive drug loading/releasing in amphiphilic copolymer PAE-PEG: integrating molecular dynamics and dissipative particle dynamics simulations.
Zhonglin Luo (2012)
10.1016/j.ijpharm.2017.03.065
Insight into the role of dual-ligand modification in low molecular weight heparin based nanocarrier for targeted delivery of doxorubicin.
H. Du (2017)
10.1016/j.biomaterials.2014.10.073
Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy.
K. Li (2015)
10.1021/acsnano.7b04855
Bridging Bio-Nano Science and Cancer Nanomedicine.
M. Björnmalm (2017)
10.1016/j.ijpharm.2012.10.030
Glycyrrhetinic acid-graft-hyaluronic acid conjugate as a carrier for synergistic targeted delivery of antitumor drugs.
L. Zhang (2013)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar