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Paget’s Disease Of Bone Revisited: The Changing Indian Scenario

K. Cherian, N. Kapoor, T. Paul
Published 2020 · Medicine

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Classically described as a disorder in which bone remodeling has “gone awry,” Paget’s disease of bone (PDB) (osteitis deformans) is the paradigm of excessive osteoclastic resorption followed by secondary bone deposition by osteoblasts.[1] A focal disorder of bone metabolism, PDB, may demonstrate a monostotic or polyostotic involvement with the commonly affected bones being the skull, spine, pelvis, and long bones of the lower extremities resulting in compromised skeletal integrity. PDB may be familial or sporadic, with both genetic and environmental determinants contributing to its pathogenesis. Among the many genetic factors implicated in the causation of PDB, those directly affecting the receptor activator of nuclear factor kappa-B (RANK)-RANK ligand pathway such as mutations in the tumor necrosis factor receptor superfamily member 11A, the ubiquitin-associated locus of sequestosome 1, zinc finger protein 687, and optineurin have been associated with Paget’s disease. As compared to genetic influences, there is limited information on the role of putative environmental triggers in disease causation. Few studies suggest a plausible viral etiology based on the presence of intranuclear inclusions in pagetic osteoclasts that resemble paramyxoviruses.[2]
This paper references
10.1148/radiographics.22.5.g02se181190
[Paget disease of bone].
H. Czickeli (1950)
10.1136/bmj.280.6222.1105
Paget's disease of bone: the Lancashire focus.
D. Barker (1980)
10.1359/jbmr.1999.14.2.192
The Epidemiology of Paget's Disease in Britain: Is the Prevalence Decreasing?
C. Cooper (1999)
10.1172/JCI9557
RANKing the importance of measles virus in Paget's disease.
F. Ross (2000)
10.1097/01.blo.0000180053.99840.27
Paget’s Sarcoma: A Historical and Outcome Review
H. Mankin (2005)
10.1359/jbmr.060704
Epidemiology of Paget's Disease in Europe: The Prevalence Is Decreasing
G. Poór (2006)
Paget's disease in diabetic subjects.
Shefali Palkar (2006)
10.1177/1759720X09351779
Paget’s disease of bone: a review of epidemiology, pathophysiology and management
J. Shaker (2009)
10.1210/jc.2014-2910
Paget's disease of bone: an endocrine society clinical practice guideline.
F. Singer (2014)
10.4103/2249-4863.192326
An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone
S. Shetty (2016)
10.11005/jbm.2017.24.2.97
Paget's Disease: Skeletal Manifestations and Effect of Bisphosphonates
Ho-Suk Kang (2017)
10.4103/ijem.IJEM_19_18
Paget's Disease of Bone: An Entity Still Exists in India
K. Cherian (2018)
10.1002/jbmr.3657
Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline
S. Ralston (2019)
10.4103/ijem.ijem_209_20
Is Paget Disease of Bone more Common in South India? Clinical Characteristics, Therapeutic Outcome and follow-up of 66 Patients from Tamil Nadu
A. Asirvatham (2020)



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