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Functionalized Diterpene Parvifloron D-loaded Hybrid Nanoparticles For Targeted Delivery In Melanoma Therapy.

C. Silva, J. Molpeceres, B. Batanero, A. S. Fernandes, N. Saraiva, J. Costa, P. Rijo, I. Figueiredo, P. Faísca, C. Reis
Published 2016 · Medicine, Materials Science

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AIM Parvifloron D is a natural diterpene with a broad and not selective cytotoxicity toward human tumor cells. In order to develop a targeted antimelanoma drug delivery platform for Parvifloron D, hybrid nanoparticles were prepared with biopolymers and functionalized with α-melanocyte stimulating hormone. Results/methodology: Nanoparticles were produced according to a solvent displacement method and the physicochemical properties were assessed. It was shown that Parvifloron D is cytotoxic and can induce, both as free and as encapsulated drug, cell death in melanoma cells (human A375 and mouse B16V5). Parvifloron D-loaded nanoparticles showed a high encapsulation efficiency (87%) and a sustained release profile. In vitro experiments showed the nanoparticles' uptake and cell internalization. CONCLUSION Hybrid nanoparticles appear to be a promising platform for long-term drug release, presenting the desired structure and a robust performance for targeted anticancer therapy.
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