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Contact Lenses As Drug Reservoirs & Delivery Systems: The Successes & Challenges.

Amr Elshaer, Baljit Ghatora, S. Mustafa, R. Alany
Published 2014 · Medicine

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Although conventional eye drops comprise over 90% of the marketed ocular dosage forms, they do have limitations, such as poor ocular drug bioavailability and systemic side effects; contact lenses are amongst the new delivery systems and devices that could overcome some of these problems. The most common approach to load drug molecules into contact lenses includes soaking in a drug solution. This approach had some success, but failed to achieve controlled/sustained drug release to the eye. On [corrected] the other hand, nanoreservoir systems comprising nanoparticles, cyclodextrins, liposomes or surfactant aggregates being incorporated into the contact lenses could offer a plausible solution. This review highlights the status quo with contact lenses as ocular drug-delivery carriers and identifies possible future directions.
This paper references
10.1002/mabi.200900204
Cyclodextrin complexation for affinity-based antibiotic delivery.
T. R. Thatiparti (2010)
Hydrogel lens monomer constituents modulate protein sorption.
Q. Garrett (2000)
Application of cyclodextrins in pharmaceutical preparations
K Uekama (1994)
10.1016/S0168-3659(02)00213-4
Timolol uptake and release by imprinted soft contact lenses made of N,N-diethylacrylamide and methacrylic acid.
Haruyuki Hiratani (2002)
10.1016/J.IJPHARM.2004.11.033
Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle.
D. Gulsen (2005)
10.1136/bjo.72.2.150
Drug delivery through soft contact lenses.
M. R. Jain (1988)
10.1016/J.CLAE.2004.03.001
Parameter stability of soft contact lenses made from different materials.
I. Tranoudis (2004)
10.1016/j.drudis.2012.01.014
Contact lenses in ocular therapeutics.
Himanshu Gupta (2012)
10.1167/iovs.10-6935
A prototype antifungal contact lens.
Joseph B. Ciolino (2011)
Contact angles
BA Pethica (1961)
10.1002/JBM.820260914
Polymeric hydrogels for soft contact lenses.
J. Singh (1992)
10.1163/092050611X569060
The Competing Effects of Hyaluronic and Methacrylic Acid in Model Contact Lenses
Andrea Weeks (2012)
10.1016/S0378-5173(03)00124-8
In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials.
C. Karlgard (2003)
10.1016/J.CLAE.2012.10.045
Barriers to drug delivery via contact lenses
N. Brennan (2012)
10.1097/00006324-198104000-00012
Tear Film Physiology and Contact Lens Wear. II. Contact Lens‐Tear Film Interaction
F. Holly (1981)
10.1016/J.JCONREL.2006.05.003
Imprinted soft contact lenses as norfloxacin delivery systems.
C. Alvarez-Lorenzo (2006)
10.1167/IOVS.02-0731
Precorneal and pre- and postlens tear film thickness measured indirectly with optical coherence tomography.
J. Wang (2003)
10.1016/j.clae.2013.09.008
Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles.
Bibi Sedigheh Fazly Bazzaz (2014)
10.3390/ma5040684
Release of Ciprofloxacin-HCl and Dexamethasone Phosphate by Hyaluronic Acid Containing Silicone Polymers
D. Nguyen (2012)
Basic contact lens practice . Part 12 . Therapeutic contact lenses
J Veys (1996)
10.1016/j.actbio.2009.07.021
Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release.
J. Xu (2010)
10.2165/00002018-200225010-00004
Locally Administered Ocular Corticosteroids
C. McGhee (2002)
10.1167/IOVS.02-1068
Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles.
Jean-Louis Bourges (2003)
10.1097/OPX.0b013e3182639dc8
Delivery of Ketotifen Fumarate by Commercial Contact Lens Materials
Anthony Soluri (2012)
10.1016/j.jconrel.2012.06.017
Extended drug delivery by contact lenses for glaucoma therapy.
Cheng-Chun Peng (2012)
10.1159/000055638
Effect of Particle Size of Polymeric Nanospheres on Intravitreal Kinetics
E. Sakurai (2000)
COMPARATIVE REVIEW ON CONVENTIONAL AND ADVANCED OCULAR DRUG DELIVERY FORMULATIONS
Karan Arul (2010)
10.1080/02713680490513209
Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats
S. Wang (2004)
10.5497/WJP.V2.I2.47
Ocular drug delivery systems: An overview.
Ashaben Patel (2013)
10.1016/0169-409X(95)00012-V
Ocular drug delivery conventional ocular formulations
John C. Lang (1995)
10.1016/J.EXER.2003.10.004
Topical drug delivery in the eye.
C. Wilson (2004)
10.1016/J.JCONREL.2007.09.006
Zero-order therapeutic release from imprinted hydrogel contact lenses within in vitro physiological ocular tear flow.
M. Ali (2007)
10.1016/S0142-9612(03)00622-7
The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems.
Haruyuki Hiratani (2004)
Studies on the uptake and release of fluoroquinolones by disposable contact lenses.
X. Tian (2001)
10.1002/APP.22080
Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses
T. Sato (2005)
10.1007/s002280050635
Improved penetration of aminoglycosides and fluoroquinolones into the aqueous humour of patients by means of Acuvue contact lenses
E.-M. Hehl (1999)
10.4103/0255-0857.83903
Antibiotic resistance in ocular bacterial pathogens.
S. Sharma (2011)
10.1016/S0168-3659(03)00368-7
Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens.
Rei Uchida (2003)
10.1016/j.jconrel.2011.06.028
Extended cyclosporine delivery by silicone-hydrogel contact lenses.
Cheng-Chun Peng (2011)
10.1021/nn5002968
Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release
H. Kim (2014)
10.1002/JBM.A.31147
Fabrication and characterization of contact lenses bearing surface-immobilized layers of intact liposomes.
A. Danion (2007)
10.1016/j.jconrel.2011.09.087
Sustained in vivo release from imprinted therapeutic contact lenses.
A. Tieppo (2012)
10.1016/j.clae.2011.12.005
Protein deposition on contact lenses: the past, the present, and the future.
Doerte Luensmann (2012)
Ophthalmic Drug Delivery system - A Review
H. A. Patel (2010)
10.1021/CM025541X
Refractive index matching: A general method for enhancing the optical clarity of a hydrogel matrix
Jeffery Franklin and (2002)
10.1016/0378-5173(95)00048-N
Ocular drug delivery: A comparison of transcorneal iontophoresis to corneal collagen shields
M. Callegan (1995)
10.1016/J.IJPHARM.2006.10.044
Cyclodextrins and their pharmaceutical applications.
T. Loftsson (2007)
10.1097/00006324-199312000-00004
Continuous Drug Delivery Through the Use of Disposable Contact Lenses
G. Lesher (1993)
A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer.
D. Meadows (2002)
10.1016/j.biomaterials.2010.01.113
Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers.
Cheng-Chun Peng (2010)
10.1097/ICL.0b013e31827d1297
The Future of Silicone Hydrogels
P. Sankaridurg (2013)
Adsorption of levocabastine eye drops by soft contact lenses and its effects in rabbit eyes.
T. Momose (1997)
10.1016/J.CLAE.2007.09.001
The effect of lens wear on refractive index of conventional hydrogel and silicone-hydrogel contact lenses: a comparative study.
M. Lira (2008)
10.1016/S1888-4296(10)70020-0
Ability of silver-impregnated contact lenses to control microbial growth and colonisation
M. Willcox (2010)
10.1111/J.1600-0420.2007.00885.X
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.
H. Sigurdsson (2007)
10.1517/17425240902895972
Multiple-pulse drug delivery systems: setting a new paradigm for infectious disease therapy
N. Saigal (2009)
10.1016/S1773-2247(14)50021-4
Review of ophthalmic drug delivery by contact lenses
Kuan-Hui Hsu (2014)
10.1002/(SICI)1097-4628(19990418)72:3<321::AID-APP2>3.0.CO;2-L
Determination of the oxygen transmissibility and permeability of hydrogel contact lenses
V. Compañ (1999)
10.1038/185117A0
Hydrophilic Gels for Biological Use
O. Wichterle (1960)
10.1211/0022357044526
An ocular drug delivery system containing zinc diethyldithiocarbamate and HPβCD inclusion complex ‐ corneal permeability, anti‐cataract effects and mechanism studies
S. Wang (2004)
10.1002/POLC.5070660130
Surface characterization of poly(hydroxyethyl methacrylate) and related polymers. I. Contact angle methods in water
J. D. Andrade (2007)
10.1080/02713680500346633
Dispersion of DMPC Liposomes in Contact Lenses for Ophthalmic Drug Delivery
D. Gulsen (2005)
Sur la fermentation de la fecule par l ’ action du ferment butyrique
A Villiers (1891)
10.1002/JPS.20871
Antibacterial activity of contact lenses bearing surface-immobilized layers of intact liposomes loaded with levofloxacin.
A. Danion (2007)
10.1021/IE0507934
Modeling Ophthalmic Drug Delivery by Soaked Contact Lenses
Chi-Chung Li (2006)
10.1016/S0142-9612(01)00165-X
Soft contact lens polymers: an evolution.
P. C. Nicolson (2001)
10.1016/J.BIOMATERIALS.2005.04.011
Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups.
Y. Liu (2005)
10.1016/j.ijpharm.2008.05.028
Ophthalmic delivery of Cyclosporine A from Brij-97 microemulsion and surfactant-laden p-HEMA hydrogels.
Yash Kapoor (2008)
Penetration of topical ciprofloxacin by presoaked medicated soft contact lenses.
D. Kalaycı (1999)
10.1097/01.opx.0000204513.76568.57
Rewetting Drops Containing Surface Active Agents Improve the Clinical Performance of Silicone Hydrogel Contact Lenses
L. Subbaraman (2006)
10.1016/J.CLAE.2004.08.003
Water properties of soft contact lens materials.
I. Tranoudis (2004)
10.1016/J.ADDR.2005.07.005
The use of mucoadhesive polymers in ocular drug delivery.
A. Ludwig (2005)
Refractive index calculation of hydrogel lenses
W Tuerle (1984)
10.1002/APP.38114
Effect of anionic/siloxy groups on the release of ofloxacin from soft contact lenses
Y. Yamazaki (2013)
10.4172/2161-1459.1000145
Insights to Using Contact Lenses for Drug Delivery
Chau-Minh Phan (2013)
10.1111/j.1444-0938.2010.00459.x
Contact lenses as a drug delivery device for epidermal growth factor in the treatment of ocular wounds
C. Schultz (2010)
10.1016/j.biomaterials.2009.11.087
Cyclodextrin-based device coatings for affinity-based release of antibiotics.
Thimma R. Thatiparti (2010)
10.1167/iovs.12-10614
Development and efficacy of a drug-releasing soft contact lens.
Koji Kakisu (2013)
10.1248/BPB.30.1768
Ability of poly-L-arginine to enhance drug absorption into aqueous humor and vitreous body after instillation in rabbits.
E. Nemoto (2007)
10.1177/0885328211410999
Hyaluronic acid as an internal wetting agent in model DMAA/TRIS contact lenses
Andrea Weeks (2012)
10.1016/J.CARBPOL.2010.01.004
γ-Cyclodextrin hydrogels and semi-interpenetrating networks for sustained delivery of dexamethasone
Maria D. Moya-Ortega (2010)
10.1155/2011/814163
Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs
X. Hu (2011)
10.1016/S0167-7799(98)01220-7
Novel applications of liposomes.
D. Lasic (1998)
10.1016/j.biomaterials.2012.12.027
Extended delivery of an anionic drug by contact lens loaded with a cationic surfactant.
Lokendrakumar C. Bengani (2013)
10.1016/j.clae.2012.02.006
Effects of aqueous polymeric surfactants on silicone-hydrogel soft- contact-lens wettability and bacterial adhesion of Pseudomonas aeruginosa.
V. Tran (2012)
Use of hydrophilic contact lenses to increase ocular penetration of topical drugs.
S. Waltman (1970)
10.1016/J.BIOMATERIALS.2004.04.030
Ocular release of timolol from molecularly imprinted soft contact lenses.
Haruyuki Hiratani (2005)
10.1016/j.visres.2007.07.012
Nanoparticle applications in ocular gene therapy
Xue Cai (2008)
10.1016/S0169-409X(98)00052-0
Mechanisms of drug release from cyclodextrin complexes.
Stella (1999)
10.1016/j.biomaterials.2011.10.076
Temperature sensitive contact lenses for triggered ophthalmic drug delivery.
H. J. Jung (2012)
10.1046/j.1475-1313.2003.00147.x
The assessment of automated measures of hydrogel contact lens refractive index
J. Nichols (2003)
A preliminary study of the adsorption and release of preservatives by contact lenses and collagen shields.
P. Lumbroso (1996)
10.1002/JPS.20761
Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers.
Paula Andrade-Vivero (2007)



This paper is referenced by
10.15406/PPIJ.2017.05.00119
Contact lenses: clinical evaluation, associated challenges and perspectives
Reynalyn Mosuela (2017)
10.1002/9781119640240.ch11
Vaginal Bioadhesive Drug Delivery Systems and Their Applications
Anju Sharma (2020)
10.1016/j.cis.2018.11.008
Pharmaceutical applications of chitosan.
Z. Shariatinia (2019)
10.1016/j.ijpharm.2018.12.028
Dual drug delivery from intraocular lens material for prophylaxis of endophthalmitis in cataract surgery
A. Topete (2019)
10.1007/978-3-319-29346-2_10
Ocular Bioadhesives and Their Applications in Ophthalmic Drug Delivery
Rakesh K. Tekade (2016)
10.1371/journal.pone.0189778
Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release
X. Li (2017)
10.1016/j.colsurfb.2017.12.024
Adherence of Pseudomonas aeruginosa onto surfactant-laden contact lenses.
Reynalyn Mosuela (2018)
10.1016/j.ejpb.2017.06.016
Electrically atomised formulations of timolol maleate for direct and on‐demand ocular lens coatings
P. Mehta (2017)
10.1016/j.colsurfb.2016.07.047
Chitosan/alginate based multilayers to control drug release from ophthalmic lens.
Diana Silva (2016)
10.1016/j.ejps.2018.02.017
Improving sustained drug delivery from ophthalmic lens materials through the control of temperature and time of loading
A. Topete (2018)
10.1586/17469899.2015.1036031
Treatment of ocular allergies: nonpharmacologic, pharmacologic and immunotherapy
Paramdeep Bilkhu (2015)
10.1016/j.jtos.2018.11.006
A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa.
Matteo M E Metruccio (2019)
10.1007/s13346-016-0303-1
Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling
A. Pimenta (2016)
10.1016/j.clae.2015.01.002
Impact in contact lenses and the anterior eye--challenges prevailing in 2015.
J. Wolffsohn (2015)
10.4155/tde-2017-0018
Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug-delivery devices.
P. Mehta (2017)
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