Online citations, reference lists, and bibliographies.
Referencing for people who value simplicity, privacy, and speed.
Get Citationsy
← Back to Search

Vitamin D Receptor (VDR) Polymorphisms And Skin Cancer

N. Denzer, T. Vogt, J. Reichrath
Published 2011 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Skin cancer is the most common cancer in humans. There are several types of skin cancer that include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). The associations of VDR polymorphisms with skin cancer risk are not well characterized so far. Only a few epidemiologic studies have directly addressed the relationship between VDR polymorphisms and the incidence and prognosis of MM. To make the most of the available information on VDR polymorphisms and skin cancer (MM, BCC and SCC), we undertook a systematic review of published studies. In conclusion, data summarized in this review support the concept that the vitamin D endocrine system (VDES) is of importance for pathogenesis and progression of MM and other types of skin cancer.
This paper references
10.1016/0092-8674(91)90301-E
RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
V. Yu (1991)
10.4161/derm.1.1.7674
The unfavorable effect of the A allele of the vitamin D receptor promoter polymorphism A-1012G has different mechanisms related to susceptibility and outcome of malignant melanoma
J. A. Halsall (2009)
10.1359/jbmr.1999.14.2.240
The Caudal‐Related Homeodomain Protein Cdx‐2 Regulates Vitamin D Receptor Gene Expression in the Small Intestine
H. Yamamoto (1999)
10.1093/CARCIN/BGL156
Polymorphisms in the MTHFR and VDR genes and skin cancer risk.
J. Han (2007)
10.1126/SCIENCE.505004
Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid.
W. Stumpf (1979)
10.1073/PNAS.89.15.6665
Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.
N. Morrison (1992)
Cloning the expression of full length cDNA encoding human vitamin D receptor
AR Baker (1988)
10.1097/01213011-200505000-00011
Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis
J. A. Halsall (2005)
25-Dihydroxyvitamin D 3 Has a Direct Effect on Naive CD 4 T Cells to Enhance the Development of Th 2 Cells 1
A. Boonstra (2001)
10.1016/B978-0-12-571144-9.50013-2
Molecular biology of the vitamin D hormone.
M. R. Haussler (1988)
10.1067/MJD.2000.103343
Clinical presentation of actinic keratoses and squamous cell carcinoma.
R. Moy (2000)
Reduced serum 25-hydroxyvitamin D levels in stage IV melanoma patients.
B. Nürnberg (2009)
10.1016/S0167-5699(00)01712-6
Transcriptional regulation of Th1/Th2 polarization.
J. Rengarajan (2000)
10.1023/A:1010062929140
Molecular Nature of the Vitamin D Receptor and its Role in Regulation of Gene Expression
P. Jurutka (2004)
10.1002/JBMR.5650071212
Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q13–14
M. Labuda (1992)
10.1002/cncr.23867
Vitamin D receptor polymorphisms and the risk of cutaneous melanoma
S. Mocellin (2008)
10.1002/JBMR.5650110908
A large‐scale population‐based study of the association of vitamin D receptor gene polymorphisms with bone mineral density
A. Uitterlinden (1996)
10.1016/j.ejca.2008.10.003
Vitamin D and skin cancer: a meta-analysis.
S. Gandini (2009)
10.1186/1471-2407-8-385
Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies
E. Barroso (2008)
10.1111/j.1365-2133.2008.08745.x
Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin
M. Carless (2008)
10.1016/0092-8674(92)90478-U
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
M. Leid (1992)
10.1046/j.1365-2265.2000.00909.x
Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1,25‐dihydroxyvitamin D3
E. Colin (2000)
10.1185/030079908X253519
Molecular basis of the potential of vitamin D to prevent cancer
Betty A. Ingraham (2008)
10.1093/HMG/2.4.487
ApaI, BsmI, EcoRV and TaqI polymorphisms at the human vitamin D receptor gene locus in Caucasians, blacks and Asians.
F. G. Hustmyer (1993)
10.4049/jimmunol.167.9.4974
1α,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4+ T Cells to Enhance the Development of Th2 Cells1
A. Boonstra (2001)
10.1359/jbmr.1997.12.6.915
A Vitamin D Receptor Gene Polymorphism in the Translation Initiation Codon: Effect on Protein Activity and Relation to Bone Mineral Density in Japanese Women
H. Arai (1997)
10.1210/JCEM.83.7.4862
Vitamin D receptor (VDR) and parathyroid hormone messenger ribonucleic acid levels correspond to polymorphic VDR alleles in human parathyroid tumors.
T. Carling (1998)
10.1097/00007611-200007000-00023
Actinic keratosis: time to call a spade a spade.
C. Evans (2000)
10.1016/S1011-1344(01)00206-8
Direct and indirect effects of UV radiation on DNA and its components.
J. Ravanat (2001)
Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians.
J. Ma (1998)
10.1038/SJ.JID.5700544
Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma.
C. Li (2007)
10.1093/CARCIN/BGL257
DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma.
Joanne E Povey (2007)
Modeling Transcription Factor Binding Sites with Gibbs Sampling and Minimum Description Length Encoding
J. Schug (1997)
Retinoic X receptor interacts with nuclear receptors in retinoic acid, thyreoid hormone and vitamin D 3 signalling
SA Kliewer (1992)
10.1016/S0925-4439(99)00007-1
Vitamin D receptor 3'-untranslated region polymorphisms: lack of effect on mRNA stability.
L. Durrin (1999)
10.1086/497438
Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study.
Y. Fang (2005)
Are human vitamin D receptor polymorphisms functionally significant? In: Vitamin D Endocrine system, Structural, Biological, Genetic and Clinical Aspects
G K Whitfield (2000)
10.1002/JBMR.5650111204
The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal mexican‐American women
C. Gross (1996)
10.1111/j.1365-2133.2006.07620.x
Association between cutaneous melanoma, Breslow thickness and vitamin D receptor BsmI polymorphism
C. Santonocito (2007)
10.1016/j.ejca.2009.06.011
Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data.
J. Randerson-Moor (2009)
The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Kim Köstner (2009)
10.1016/j.canep.2009.06.006
Vitamin D receptor variants and the malignant melanoma risk: a population-based study.
P. Gapska (2009)
10.1002/ijc.23357
Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non‐Hispanic whites in Texas: A case–control study
C. Li (2008)
10.1093/NAR/17.5.2150
ApaI dimorphism at the human vitamin D receptor gene locus.
J. Faraco (1989)
10.1359/jbmr.2003.18.9.1632
Cdx‐2 Polymorphism in the Promoter Region of the Human Vitamin D Receptor Gene Determines Susceptibility to Fracture in the Elderly
Y. Fang (2003)
10.1210/MEND.14.3.0435
The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB.
P. Jurutka (2000)
10.1016/J.GENE.2004.05.014
Genetics and biology of vitamin D receptor polymorphisms.
A. Uitterlinden (2004)
A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection.
T. Saijo (1991)
10.1073/PNAS.85.10.3294
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
A. R. Baker (1988)
10.1038/sj.bjc.6602006
A novel polymorphism in the 1A promoter region of the vitamin D receptor is associated with altered susceptibilty and prognosis in malignant melanoma
J. A. Halsall (2004)
10.1038/367284A0
Prediction of bone density from vitamin D receptor alleles
N. Morrison (1994)
10.1200/JCO.2009.22.1135
Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma.
J. Newton-Bishop (2009)
Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma.
P. E. Hutchinson (2000)
10.1038/355446A0
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling
S. Kliewer (1992)
10.1023/A:1018440801577
Sunlight and cancer
D. English (2004)
Consequences of vitamin D receptor gene polymorphisms for growths inhibition of cultured human peripheral blood mononuclear cells
EM Colin (2000)
Are human vitamin D receptor polymorphisms functionally significant
GK Whitfield (2000)



This paper is referenced by
10.1111/iji.12199
Association between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto's thyroiditis: preliminary data from female patients in Serbia
J. Djurović (2015)
10.1080/09168451.2016.1184561
Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3
J. Lee (2016)
10.1007/978-3-642-19683-6_8
Cutaneous Secosteroidal System
A. Słomiński (2012)
10.1007/s10552-012-0018-7
An exploratory analysis of common genetic variants in the vitamin D pathway including genome-wide associated variants in relation to glioma risk and outcome
Gabriella M. Anic (2012)
10.1155/2013/953974
The Associated Ion between the VDR Gene Polymorphisms and Susceptibility to Hepatocellular Carcinoma and the Clinicopathological Features in Subjects Infected with HBV
X. Yao (2013)
10.5772/55324
The Impact of Vitamin D in Cancer
K. Luong (2012)
Einfluss unterschiedlicher UV-Bestrahlungssysteme auf den 25-Hydroxyvitamin D-Serumspiegel und andere Gesundheitsparameter
Thomas Vogt (2013)
10.1007/s10528-015-9710-0
Association Between Vitamin D Receptor Polymorphism and Familial Mediterranean Fever Disease in Turkish Children
S. Kızıldağ (2015)
For Peer Review Vitamin D receptor polymorphism FokI and cancer risk: A comprehensive meta-analysis
Elena Pasquali (2014)
10.1016/j.febslet.2013.01.041
Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis
Stephen Hyter (2013)
10.1097/CMR.0000000000000095
Increased risk of developing cutaneous malignant melanoma is associated with variation in pigmentation genes and VDR, and may involve epistatic effects
A. Kosiniak-Kamysz (2014)
10.1016/j.mce.2017.05.001
Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond
J. Reichrath (2017)
10.1016/j.steroids.2018.03.003
Vitamin D deficiency and vitamin D receptor variants in mothers and their neonates are risk factors for neonatal sepsis
Safaa I. Tayel (2018)
10.1016/j.bcp.2012.09.032
Rat CYP24A1 acts on 20-hydroxyvitamin D(3) producing hydroxylated products with increased biological activity.
Elaine W. Tieu (2012)
10.3390/jcm9123819
Vitamin D Receptor Polymorphisms and Non-Melanoma Skin Cancer Risk: A Case-Control Study
Carolina Morgado-Águila (2020)
10.1080/19381980.2014.1004018
Exponentially increasing incidences of cutaneous malignant melanoma in Europe correlate with low personal annual UV doses and suggests 2 major risk factors
S. Merrill (2015)
Invited Review Vitamin D and skin cancer
Erin M. Burns (2015)
10.21873/ANTICANRES.11784
Vitamin D Receptor Polymorphism and Cancer: An Update.
V. Rai (2017)
10.1016/j.jaad.2014.06.016
Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis.
E. Murzaku (2014)
The relationship between vitamin D status and the risk of cancer among older adults
J. Ordóñez-Mena (2016)
10.4161/derm.17544
Ancient friends, revisited
J. Reichrath (2011)
10.3109/00365513.2012.682876
Hope and challenge: The importance of ultraviolet (UV) radiation for cutaneous Vitamin D synthesis and skin cancer
J. Reichrath (2012)
10.4161/derm.24156
The relevance of the vitamin D endocrine system (VDES) for tumorigenesis, prevention, and treatment of non-melanoma skin cancer (NMSC)
J. Reichrath (2013)
10.1016/j.cllc.2013.01.004
Vitamin D receptor genetic variants are associated with chemotherapy response and prognosis in patients with advanced non-small-cell lung cancer.
L. Xiong (2013)
10.1001/jamadermatol.2017.1976
Association of Vitamin D Receptor Polymorphisms With the Risk of Nonmelanoma Skin Cancer in Adults
E. M. Burns (2017)
10.1016/bs.afnr.2015.06.003
Vitamin D, Cancer Risk, and Mortality.
E. Tagliabue (2015)
10.1111/php.12382
Vitamin D and Skin Cancer
E. M. Burns (2015)
10.1007/s11154-016-9353-4
Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook
J. Reichrath (2016)
10.1159/000485952
Rs739837 Polymorphism in MiR-885-3p Binding Site Within 3’-Untranslated Region of Vitamin D Receptor is Associated with a Decreased Risk of Pressure Ulcers
X. Ji (2017)
10.1007/978-3-662-47081-7_3
Genomics of SCC: Tumor Formation, Progression, and Future Therapeutic Implications for High-Risk Cutaneous Squamous Cell Carcinoma
C. Harwood (2016)
10.1007/978-3-030-46227-7_13
The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers.
A. Slominski (2020)
10.1016/j.mgene.2020.100766
Vitamin D receptor (VDR) gene polymorphism BsmI in Syrian breast cancer patients
S. Haddad (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar