Primary Open-Angle Glaucoma In Individuals Of African Descent: A Review Of Risk Factors
Rebecca J Salowe, J. Salinas, Neil H Farbman, A. Mohammed, Joshua Zubin Warren, A. Rhodes, A. Brucker, Meredith Regina, E. Miller-Ellis, P. Sankar, A. Lehman, J. O'Brien
Published 2015 · Medicine
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Objective To identify the major risk factors for primary open-angle glaucoma (POAG) in individuals of African descent. Methods We searched PubMed for relevant articles, with results spanning April 1947 to present. All abstracts were reviewed and, where relevant to POAG and race, articles were catalogued and analyzed. Additional sources were identified through citations in articles returned by our search. Results Numerous potential POAG risk factors were identified and organized into categories by demographics (age, sex, and skin color), lifestyle choices (smoking, alcohol), comorbidities (hypertension, diabetes, and obesity), ophthalmic findings (eye structure, central corneal thickness, corneal hysteresis, elevated intraocular pressure, myopia, cataract, and vascular abnormalities), family history, socioeconomic status, and adherence. Older age, male sex, lower central corneal thickness, decreased corneal hysteresis, elevated intraocular pressure, myopia, vascular abnormalities, and positive family history were definitively associated with increased risk of POAG. Conclusions Individuals at greatest risk for POAG should be screened by an ophthalmologist to allow earlier detection and to slow disease progression. Further studies on the genetics of the disease will provide more insight into underlying pathologic mechanisms and could lead to improved therapeutic interventions. Continued research in urban areas with large populations of blacks is especially needed.
This paper references
Large Diurnal Fluctuations in Intraocular Pressure Are an Independent Risk Factor in Patients With Glaucoma
S. Asrani (2000)
The primary open-angle african american glaucoma genetics study: baseline demographics.
Emily S. Charlson (2015)
Analysis of progressive change in automated visual fields in glaucoma.
S. Smith (1996)
Blindness and glaucoma: a comparison of patients progressing to blindness from glaucoma with patients maintaining vision.
J. E. Oliver (2002)
Comparison of the corneal biomechanical properties with the Ocular Response Analyzer® (ORA) in African and Caucasian normal subjects and patients with glaucoma
M. Detry-Morel (2012)
Barbados Eye Studies Group. Incident open-angle glaucoma and intraocular pressure
B Nemesure (2007)
Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation 129: e28-28e292
AS Go (2014)
Central visual field progression in normal-tension glaucoma patients with autonomic dysfunction.
Hae-Young Lopilly Park (2014)
Analysis of Glaucoma-related Mortality in the United States Using Death Certificate Data
J. Bennion (2008)
Risk factors for poor adherence to eyedrops in electronically monitored patients with glaucoma.
D. Friedman (2009)
Comparative human aqueous dynamics study between black and white subjects with glaucoma.
L. Beltran-Agulló (2011)
Racial differences in optic nerve head parameters.
T. Chi (1989)
The impact of ocular blood flow in glaucoma
J. Flammer (2002)
Risk factors for incident open-angle glaucoma: the Barbados Eye Studies.
M. C. Leske (2008)
The Salisbury Eye Evaluation Project
D. Friedman (2007)
Optic Nerve Head (ONH) Topographic Analysis by Stratus OCT in Normal Subjects: Correlation to Disc Size, Age, and Ethnicity
B. Marsh (2010)
The Glaucoma Laser Trial (GLT): 5. Subgroup differences at enrollment. Glaucoma Laser Trial Research Group.
Central Corneal Thickness in Children: Racial Differences (Black vs. White) and Correlation With Measured Intraocular Pressure
K. Muir (2006)
Racial differences in the association between optic disc topography and early glaucoma.
C. Girkin (2003)
The relationship between glaucoma and myopia: the Blue Mountains Eye Study.
P. Mitchell (1999)
Factors contributing to the progression of visual field damage in eyes with normal-tension glaucoma.
M. Araie (1994)
The effects of cigarette smoking on intraocular pressure and arterial blood pressure of normotensive young Nigerian male adults.
C O Timothy (2007)
Why do some people go blind from glaucoma?
W. W. Grant (1982)
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Talicia Tarver (2014)
Family History and Risk of Primary Open Angle Glaucoma
J. Tielsch (2010)
Risk factors for primary open angle glaucoma.
J. Katz (1988)
Race and primary open-angle glaucoma.
M. Martin (1985)
Impact of glaucoma, lens opacities, and cataract surgery on visual functioning and related quality of life: the Barbados Eye Studies.
S. Wu (2008)
Incident open-angle glaucoma and intraocular pressure.
B. Nemesure (2007)
T Chi (2015)
Predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study.
K. Nouri-Mahdavi (2004)
Comparison of corneal biomechanical properties between healthy blacks and whites using the Ocular Response Analyzer.
M. T. Leite (2010)
Collaborative Normal-Tension Glaucoma Study Group. Risk factors for progression of visual field abnormalities in normal-tension glaucoma
S Drance (2001)
Progression of visual field loss in untreated glaucoma patients and glaucoma suspects in St. Lucia, West Indies.
M. Wilson (2002)
Deprivation and late presentation of glaucoma: case-control study
S. Fraser (2001)
Socioeconomic differences in glaucoma patients' knowledge, need for information and expectations of treatments.
J. G. Hoevenaars (2006)
Differences in optic disc topography between black and white normal subjects.
C. Girkin (2005)
Intraocular pressure, Goldmann applanation tension, corneal thickness, and corneal curvature in Caucasians, Asians, Hispanics, and African Americans.
M. Shimmyo (2004)
Heart disease and stroke statistics - -
AS Go (2014)
Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study.
ROGER C.W. Wolfs (1997)
Diurnal variation of intraocular pressure in the normal eye.
G. de Venecia (1963)
Heart disease and stroke statistics--2014 update: a report from the
A S Go (2014)
Glaucoma Medication Adherence among African Americans: Program Development
L. Dreer (2013)
Open-angle glaucoma and mortality: The Barbados Eye Studies.
S. Wu (2008)
Mitochondrial Genome Analysis of Primary Open Angle Glaucoma Patients
D. Banerjee (2013)
Increased Rate of Visual Field Loss Associated with Larger Initial Visual Field Threshold Values on Follow-Up of Open-Angle Glaucoma
B. Schwartz (2004)
Risk factors for open-angle glaucoma: a case-control study.
D. Kaimbo (2001)
Overcoming Health Care Disparities and Poverty in a Large African-American Population using Glaucoma as a Model
Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey.
J. Tielsch (1994)
Statistical Abstract of the United States
U. Bureau (2004)
Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study.
D. Musch (2011)
Variation in corneal hysteresis and central corneal thickness among black, hispanic and white subjects
Sarah J. Haseltine (2012)
Quality of Life of Primary Open Angle Glaucoma Patients in Lagos, Nigeria: Clinical and Sociodemographic Correlates
A. Onakoya (2012)
BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology
MC Leske (2008)
Blindness from glaucoma.
R. Hiller (1975)
GLAUCOMAS IMPACT ON QUALITY－OF－LIFE AND ITS RELATION TO CLINICAL INDICATORS
Functional health literacy and the risk of hospital admission among Medicare managed care enrollees.
D. Baker (2002)
Number of people with glaucoma worldwide.
H. Quigley (1996)
Mitochondrial Sequence Variation in African-American Primary Open-Angle Glaucoma Patients
David W Collins (2013)
The pathophysiology and treatment of glaucoma: a review.
R. Weinreb (2014)
Race-, age-, gender-, and refractive error-related differences in the normal optic disc.
R. Varma (1994)
The Advanced Glaucoma Intervention Study (AGIS): 3. Baseline characteristics of black and white patients.
BESs Study Group (2008) Risk factors for incident open-angle glaucoma: the Barbados
MC Leske (2008)
Visual Loss in Urban and Rural Chronic Glaucoma Patients in Ghana
C. Ntim-Amponsah (2002)
Racial variability of glaucoma risk factors between African Caribbeans and Caucasians in a Canadian urban screening population.
A. K. Fansi (2009)
Risk factors for open-angle glaucoma in 260 black subjects in Congo.
D. Kaimbo Wa Kaimbo (1997)
Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage.
H. Quigley (1996)
Patient Race, Reported Problems in Using Glaucoma Medications, and Adherence
B. Sleath (2012)
Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data.
A. Broman (2008)
Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey.
A. Sommer (1991)
Race as a risk factor for progressive glaucomatous damage.
R. Wilson (1985)
Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma
E Aghaian (2004)
Risk factors for the development of glaucomatous visual field loss in ocular hypertension.
H. Quigley (1994)
Differences in Ocular Blood Flow in Glaucoma Between Patients of African and European Descent
B. Siesky (2015)
Differences in visual function and optic nerve structure between healthy eyes of blacks and whites.
L. Racette (2005)
Beliefs and Adherence to Glaucoma Treatment: A Comparison of Patients From Diverse Cultures
Gwyneth Rees (2014)
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
P. Lichter (2001)
Risk factors for poor adherence to eye drops in electronically monitored patients with glaucoma Ophthalmology
D Friedman (2009)
Primary open-angle glaucoma
R. Weinreb (2016)
Racial differences in the cause-specific prevalence of blindness in east Baltimore.
A. Sommer (1991)
The African Caribbean eye survey: Risk factors for glaucoma in a sample of African Caribbean people living in London
R. Wormald (1994)
Quality of life in newly diagnosed glaucoma patients : The Collaborative Initial Glaucoma Treatment Study.
N. Janz (2001)
D Friedman (2015)
The number of people with glaucoma worldwide in 2010 and 2020
H. Quigley (2006)
Lower Corneal Hysteresis is Associated With More Rapid Glaucomatous Visual Field Progression
C. G. De Moraes (2012)
Health literacy and vision-related quality of life
K. Muir (2008)
Glaucoma's impact on quality of life and its relation to clinical indicators. A pilot study.
M. Sherwood (1998)
Ethnic Differences in Optic Nerve Head Topography
C. S. Tsai (1995)
Glaucoma and mobility performance: the Salisbury Eye Evaluation Project.
D. Friedman (2007)
Racial influences in open-angle glaucoma.
J. Wilensky (1978)
Chronic glaucoma in Northern Ghana—A retrospective study of 397 patients
J. Verrey (1990)
Vascular Risk Factors for Open Angle Glaucoma in African Eyes
A. E. Omoti (2009)
PREDICTIVE FACTORS FOR GLAUCOMATOUS VISUAL FIELD PROGRESSION IN THE ADVANCED GLAUCOMA INTERVENTION STUDY
M. B. Shields (2005)
African Descent and Glaucoma Evaluation Study (ADAGES): II. Ancestry differences in optic disc, retinal nerve fiber layer, and macular structure in healthy subjects.
C. Girkin (2010)
The Relationship Among Race, Iris Color, Central Corneal Thickness, and Intraocular Pressure
L. Semes (2006)
Statistical abstract of the United States
D. Commerce (1878)
Age and racial variation in central corneal thickness of preschool and school-aged children.
K. Haider (2008)
Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment.
J. Tielsch (1995)
Collaborative Normal-Tension Glaucoma Study Group (2001) Risk factors for progression of visual field abnormalities in normal-tension glaucoma
S Drance (2001)
[Comparing specific disc findings of a European and a Bantu population].
Harald Krueger (2009)
The influence of socioeconomic and clinical factors upon the presenting visual field status of patients with glaucoma
S. Sukumar (2009)
Effect of race, age, and axial length on optic nerve head parameters and retinal nerve fiber layer thickness measured by Cirrus HD-OCT.
O'Rese J Knight (2012)
The effect of socio-economic deprivation on severity of glaucoma at presentation
W. S. Ng (2009)
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
M. Gordon (2002)
Primary Open-Angle Glaucoma Presentation at a Tertiary Unit in Africa: Intraocular Pressure Levels and Visual Status
M. Mafwiri (2005)
Risk factors for progression of visual field abnormalities in normal-tension glaucoma.
S. Drance (2001)
Unpublished) Overcoming Health Care Disparities and Poverty in a Large African-American Population using Glaucoma as a Model
Barbados Eye Studies Group (2007) Incident open-angle glaucoma and intraocular pressure
B Nemesure (2007)
Office visits to ophthalmologists and other physicians for eye care among the U.S. population, 1990.
Y. Chiang (1995)
Risk factors associated with the incidence of open-angle glaucoma: the visual impairment project.
Anhchuong Le (2003)
The Advanced Glaucoma Intervention Study (AGIS): 9. Comparison of glaucoma outcomes in black and white patients within treatment groups.
Agis Investigators (2001)
Central corneal thickness and corneal hysteresis associated with glaucoma damage.
N. Congdon (2006)
Associations with intraocular pressure in the Barbados Eye Study.
S. Wu (1997)
Barbados Eye Studies Group. Incident open-angle glaucoma and intraocular pressure. Ophthalmology
B Nemesure (2016)
Association between skin color and intraocular pressure in African Americans.
Brian L. Schwam (1995)
The Ibadan glaucoma study.
A. M. Agbeja-Baiyeroju (2003)
Risk factors for open-angle glaucoma. The Barbados Eye Study.
M. C. Leske (1995)
Why do some people go blind from glaucoma? Ophthalmology
WM Grant (1982)
Open angle glaucoma, ocular hypertension, low-tension glaucoma, and refraction.
E. Perkins (1982)
Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic.
E. Aghaian (2004)
Nine-year refractive changes in the Barbados Eye Studies.
S. Wu (2005)
Relationship between corneal hysteresis and optic nerve parameters measured with spectral domain optical coherence tomography
Daniel M. Vu (2013)
Mitochondrial abnormalities in patients with primary open-angle glaucoma.
K. Abu-Amero (2006)
Risk Factors for Open-angle Glaucoma
M. C. Leske (2010)
update : a report from the American Heart Association
Retrospective analysis of risk factors for late presentation of chronic glaucoma
S. Fraser (1999)
Differences in the trabecular meshwork between Belgian and Congolese patients with open-angle glaucoma.
P Pary-Van Ginderdeuren (1997)
High myopia as a risk factor in primary open angle glaucoma.
Sheng-ju Chen (2012)
Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography.
C. Girkin (2011)
A prospective study of diabetes, lifestyle factors, and glaucoma among African-American women.
L. Wise (2011)
This paper is referenced by
Characterizing the “POAGome”: A bioinformatics-driven approach to primary open-angle glaucoma
Ian D. Danford (2017)
Combined Endocyclophotocoagulation and Phacoemulsification in Patients with Glaucoma of African Descent
Corey W. Waldman (2019)
Glaucoma, depression and quality of life: multiple comorbidities, multiple assessments and multidisciplinary plan treatment.
Goran Pelčić (2017)
The Relationship between Vitamin D and Glaucoma: A Kangbuk Samsung Health Study
Hyun Tae Kim (2016)
Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma
Tzu-Yu Hou (2020)
Emerging Trends in The Pattern of Presentation and Risk Factors of Severity of Primary Open Glaucoma in A Tertiary Hospital in Southern Nigeria.
R. O. Momoh (2017)
Asymmetric Patterns of Visual Field Defect in Primary Open-Angle and Primary Angle-Closure Glaucoma.
S. Yousefi (2018)
Glaucoma and cigarette smoking: a review of narrative reviews
F. D. Murro (2016)
Genomic Locus Modulating Corneal Thickness in the Mouse Identifies POU6F2 as a Potential Risk of Developing Glaucoma
Rebecca King (2017)
Myocilin and Glaucoma its Risk Factors
Mahesh Kumar Lohano (2016)
Rates of Visual Field Loss in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma: Asymmetric Patterns.
Siamak Yousefi (2018)
Combined multi-modal assessment of glaucomatous damage with electroretinography and optical coherence tomography/ angiography
K. O. Al-Nosairy (2020)
Reverse engineering glaucoma
Karen Leah Lester (2018)
Rates of Intraocular Pressure Elevation and Use of Topical Antihypertensive Medication After Descemet Stripping Automated Endothelial Keratoplasty
M. Kaleem (2017)
Influencia del tabaquismo, la hipertensión arterial y la diabetes mellitus en las enfermedades oftalmológicas
W. Li (2017)
Eight-Year Incidence of Open-Angle Glaucoma in the Tema Eye Survey.
Jean-Claude Mwanza (2019)
Proportion of Glaucoma among Voluntary People Coming for Glaucoma Screening Program at Jimma University Department of Ophthalmology, Jimma, Ethiopia
Kumale Tolesa Daba (2020)
Alteration in ocular blood flow and its effect on the progression of glaucoma
S. Z. Safi (2017)
Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma
Rebecca King (2018)